Abstract:
:The gene frequency of beta-thalassemia among Filipinos is estimated to be 0.02, although little is known about the mutations involved. Recently, an extensive beta-thalassemia deletion was reported in several unrelated individuals of Filipino descent. The deletion begins approximately 4 kb upstream of the beta-globin gene, and extends 3' beyond the beta-globin gene. In this report, we identify the 5' and 3' deletion endpoints and present a polymerase chain reaction (PCR) strategy for rapid DNA diagnosis of the Filipino beta-thalassemia deletion.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Waye JS,Eng B,Hunt JA,Chui DHdoi
10.1007/BF00211021subject
Has Abstractpub_date
1994-11-01 00:00:00pages
530-2issue
5eissn
0340-6717issn
1432-1203journal_volume
94pub_type
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