Abstract:
:The intrathecal (i.t.) administration of morphine inhibits nociceptive motor responses and activity in ascending axons evoked by stimulation of nociceptive afferent nerve fibers (nociceptive sensory response) in the rat. The i.t. administration of cholecystokinin octapeptide and ceruletide inhibits nociceptive motor responses, but does not affect ascending nociceptive activity. This shows that drug-induced depression of nociceptive motor responses is not always associated with depression of the nociceptive sensory response of the spinal cord. The microiontophoretic application of substance P excites single dorsal horn neurons that respond to noxious stimulation, whereas the i.t. administration of substance P inhibits both nociceptive motor and sensory responses. Thus, the results obtained from the i.t. administration of a drug may differ from those obtained from its application to single spinal neurons. Diazepam inhibits spinal reflexes and may reduce pain sensation in humans. To assess whether a spinal action is involved in the pain-relieving effect of diazepam, experiments were carried out on spinalized rats in which activity evoked by the stimulation of nociceptive and nonnociceptive afferent nerve fibers of the sural nerve was recorded from single ascending axons below the site of spinal cord transection. Diazepam, 20 micrograms i.t., reduced activity evoked by afferent A delta and C fiber stimulation and by stimulation of afferent A beta fibers. The depressant effect caused by diazepam, 2 mg/kg i.v., on C fiber-evoked ascending activity was reduced by the i.t. injection of the benzodiazepine antagonist, Ro 15-1788 (40 micrograms), an imidazodiazepine. It is concluded that the depression by diazepam of C fiber-evoked ascending activity contributes to pain relief caused by the drug.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Jurna Isubject
Has Abstractpub_date
1984-12-01 00:00:00pages
917-20issue
6eissn
0148-396Xissn
1524-4040journal_volume
15pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract::Cavernous angiomas represent 5 to 12% of spinal vascular malformations and usually are located at the vertebral body level with possible extension into the extradural space. The intradural intramedullary cavernoma occurs in about 3% of cases, whereas extramedullary localization is extremely rare. A new case of an intr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199112000-00023
更新日期:1991-12-01 00:00:00
abstract::In an attempt to eliminate the many negative aspects of conventional extensive laminectomy, we originated in 1981 and have developed a new surgical technique called "suspension laminotomy." A basic principle of this operation is preservation and repair of the soft and bony tissue of the spine with osseous enlargement ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198712000-00033
更新日期:1987-12-01 00:00:00
abstract:OBJECTIVE:Subarachnoid hemorrhage (SAH) predisposes patients to excessive natriuresis and volume contraction. We studied the effects of postoperative administration of 5% albumin solution on sodium balance and blood volume after SAH. We also sought to identify physiological variables that influence renal sodium excreti...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006123-199804000-00048
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To study the cerebral metabolism and its relationship to cerebral blood flow (CBF) acutely after subarachnoid hemorrhage (SAH). METHODS:SAH was induced in rats by endovascular perforation of the internal carotid artery, blood injection into the prechiasmatic cistern or the cisterna magna. CBF (measured by la...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000103670.09687.7a
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Placement of spinal cord stimulating paddle leads has traditionally been performed under local anesthesia with intravenous sedation to allow intraoperative confirmation of appropriate placement. It may be difficult to maintain appropriate sedation in certain patients because of medical comorbidities. Further...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/NEU.0b013e318232ff29
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Treatment of tentorial dural arteriovenous fistulae (DAVFs) primarily draining into the vein of Galen remains a therapeutic challenge. We present two cases of ruptured galenic DAVFs that were successfully treated with gamma knife radiosurgery. CLINICAL PRESENTATION:Patient 1, a 66-year-old wom...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200003000-00039
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Hyperbaric oxygenation is a rarely used method of treatment for steroid-refractory radiation-induced edema after stereotactic radiosurgery. We present its successful implementation for a radiosurgical complication after the treatment of a deep, large arteriovenous malformation. We also review the literature o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000255343.41206.6F
更新日期:2007-03-01 00:00:00
abstract::Comprehensive anatomic and clinical analyses of 39 patients with injuries involving the transverse atlantal ligament or its osseous insertions were performed to assess the morphology of the injured ligaments and the patients' capacity to heal. Injuries of the upper cervical spine were screened with plain radiographs, ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199601000-00012
更新日期:1996-01-01 00:00:00
abstract::Different fluids used in neurosurgery were tested for the production of blood-brain barrier dysfunction by applying them to the brain surface of the cat for 3 hours. Normal saline, Ringer's solution, and Elliott's Solution B induced no obvious damage either by closed subdural perfusion or when applied to the brain sur...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198007000-00008
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:The advantages of a posterior "conventional" suboccipital approach with a midline incision over lateral, anterolateral, and anterior approaches to anteriorly placed foramen magnum meningiomas are discussed. METHODS:From 1991 to March 2000, 17 patients with foramen magnum meningiomas arising from the anterior...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-200107000-00016
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:After the resection of cranial base tumors, there may not be enough free dural margin left for reconstruction after involved bone and dura have been removed. In such a situation, dural reconstruction becomes a problem. We propose a new technique of dural closure in such cases. METHODS:A fascial graft is prep...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200109000-00043
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:Animal models and clinical studies suggest that intraventricular thrombolysis improves clot resolution and clinical outcomes among patients with intraventricular hemorrhage. However, this intervention may increase the rates of rebleeding and infection. To assess the safety and efficacy of intraventricular thr...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1227/01.neu.0000108422.10842.60
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Long-term remission rates from endoscopic transsphenoidal surgery for acromegaly and their relationship to prognostic indicators of disease aggressiveness are not well documented. OBJECTIVE:To investigate long-term remission rates in patients with acromegaly after endoscopic transsphenoidal surgery, and cor...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx020
更新日期:2017-08-01 00:00:00
abstract::Previous assessments of the value of sequential computed tomographic (CT) scanning in brain tumor patients have suffered from the heterogeneous nature of the study populations in regard to (a) pathology, (b) treatment plan, and (c) time of scanning. This report is based on the first 21 of 30 consecutive cases of gliob...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198101000-00004
更新日期:1981-01-01 00:00:00
abstract::This report describes a computed tomography-based computer-assisted stereotactic technique for performing 3rd ventriculostomy. The procedure has been performed on seven patients with acquired obstructive hydrocephalus of various etiologies. None of these patients have yet required shunting. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198606000-00021
更新日期:1986-06-01 00:00:00
abstract::The parameters of hematoporphyrin-derivative (HpD) photocytotoxicity of human glioma cells in cell culture were studied to determine the optimum wavelength and power density of light, to investigate the influence of tissue oxygenation, and to evaluate the role of singlet oxygen and free radicals in producing cell deat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198610000-00002
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:To assess the outcomes associated with C1-C2 transarticular screw fixation. METHODS:The clinical outcomes of 121 patients treated with posterior C1-C2 transarticular screws and wired posterior C1-C2 autologous bone struts were evaluated prospectively. Atlantoaxial instability was caused by rheumatoid arthrit...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199808000-00056
更新日期:1998-08-01 00:00:00
abstract::We subtotally removed nine pediatric central gliomas (five brain stem and four thalamic) with the Cavitron ultrasonic surgical aspirator (CUSA). Greater than 70% of the tumor was removed in eight of the nine cases. Evoked potentials were monitored during six of the operations. Of the six children who were operated on ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198510000-00005
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVE:A single-stage combined craniofacial-transfacial approach that exposes the midline cranial base without visible facial incisions is described. METHODS:Between 1992 and 1998, eight patients underwent surgery for five different anterior cranial base pathological findings: four angiofibromas, one mesenchymal ch...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000144209.03703.c6
更新日期:2005-01-01 00:00:00
abstract::The simple pathoanatomic concept that a narrowed spinal canal causes compression of the enclosed cord, leading to local tissue ischemia, injury, and neurological impairment, fails to explain the entire spectrum of clinical findings observed in cervical spondylotic myelopathy. A growing body of evidence indicates that ...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Distal junctional kyphosis (DJK) development after cervical deformity (CD)-corrective surgery is a growing concern for surgeons and patients. Few studies have investigated risk factors that predict the occurrence of DJK. OBJECTIVE:To predict DJK development after CD surgery using predictive modeling. METHO...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyz347
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Transcranial Doppler (TCD) ultrasonography is an important tool for noninvasive detection and monitoring of vasospasm and other pathological conditions of the intracranial vessels. OBJECTIVE:To demonstrate that image-guided TCD allows rapid identification and blood-flow analysis of specific sections of the ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31821553b2
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Because more women with cerebrospinal fluid shunts are surviving to child-bearing age, neurosurgeons, obstetricians, and other health care professionals require information about the care of these patients, especially during pregnancy and delivery. The purpose of this study was to gather comprehensive data fr...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199809000-00030
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration. OBJECTIVE:To determine if fluorescence represents a prognostic marker in LGG. METHODS:Seventy-four consecutive patients with LGG (World Health Organiza...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyy365
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:We sought to evaluate whether taurine detection in short-echo (20 ms) proton magnetic resonance spectroscopy contributes to the noninvasive differential diagnosis between medulloblastoma and cerebellar astrocytoma in children and young adults. These two types of tumor have very different prognoses and may be ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000137655.53303.c8
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Intracranial giant optic nerve gliomas, usually presumed as optic chiasmatic gliomas, are much less common. The architectural tumor form of optic nerve glioma without neurofibromatosis type 1 is usually the expansile-intraneural pattern. The exophytic optic nerve gliomas without neurofibromatos...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000204308.59999.60
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Focal or diffuse corpus callosal changes can occur in patients with active hydrocephalus who undergo shunting procedures. The neural compression caused by active hydrocephalus and the conditions that follow ventricular shunting may contribute to the development of these changes. CLINICAL PRESE...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199708000-00037
更新日期:1997-08-01 00:00:00
abstract::A case of thrombosis of the vertebral artery and an associated bursting fracture of the lower cervical spine is reported. Computed tomography revealed both the location and the spreading of the fractures of the injured spine. We recognized that the vertebral artery thrombosis was caused by an injury to the arterial wa...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198512000-00015
更新日期:1985-12-01 00:00:00
abstract::A patient who sustained an isolated transverse sacral fracture is presented. A large ventral sacral pseudomeningocele with cerebrospinal fluid (CSF) fistula developed. Eighteen previous cases of traumatic pseudomeningocele have been documented. A review of those cases leads these authors to conclude that: transverse s...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198506000-00022
更新日期:1985-06-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:We present three cases of endolymphatic sac tumors and review the previously published cases. Despite frequent extension to the cerebellopontine angle, these rare tumors have only recently been recognized by neurosurgeons. CLINICAL PRESENTATION:A 26-year-old man developed a progressive hearing...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199804000-00139
更新日期:1998-04-01 00:00:00