[Statistical study of the risk of cardiovascular disease in hysterectomized patients].

Abstract:

:The risk of atherosclerotic or hypertensive cardiovascular disease increases after physiological or surgical menopause, irrespective of whether or not the ovaries are removed. In order to evaluate the direct contribution of the uterus in cutting down the incidence of cardiovascular diseases, the clinical records of 1551 cardiovascular patients and 296 healthy women were examined. All subjects were divided into 8 different groups according to their age. The following data were considered: 1) the incidence of cardiovascular diseases; 2) the number of subjects in physiological or surgical menopause; 3) the number of women hysterectomised in premenopause; 4) the number of women who underwent hysterectomy and bilateral salpingo-oophorectomy in premenopause; 5) the number of women who underwent either operation before or after the menopause. It was found that both in hysterectomised and not hysterectomised women the hypertensive and ischaemic cardiovascular pathologies prevailed in the younger and older groups respectively. Among the patients with cardiovascular diseases the percentage of subjects who had undergone hysterectomy or hysterectomy with bilateral oophorectomy was significantly higher (p less than 0.05) than in the controls. The difference was particularly marked in the younger groups. These data indicate that when the uterus is properly stimulated by the oestrogens, is able to produce a protective factor against cardiovascular diseases. It has been suggested that this factor may be prostacyclin, a potent vasodilator and the most potent inhibitor of platelet aggregation yet discovered. The epidemiological evidence alone that premenopausal hysterectomy increases the risk of cardiovascular disease should be an important consideration in weighing the risks and benefits of the procedure. If the epidemiological data can be supported by a definite mechanism of action via prostacyclin, then current indications for hysterectomy must be carefully reconsidered.

journal_name

Minerva Med

journal_title

Minerva medica

authors

Pastore G,Benedetto C,Ardizzoja M,Cavallero G,Massobrio M

subject

Has Abstract

pub_date

1985-04-28 00:00:00

pages

827-34

issue

17-18

eissn

0026-4806

issn

1827-1669

journal_volume

76

pub_type

杂志文章
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  • [Respiratory functional decline after 5 years in patients with silicosis and asbestosis].

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  • [Daily secretion of parathyroid hormone in adult subjects].

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  • [Liver pathology caused by drugs. Pathogenetic, histopathological and clinical notes and case reports].

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  • [Muscle fatigue and dyspnea].

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  • [Castleman's disease. A clinical case].

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    doi:

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  • [Epidemiology of hepatitis B virus infection in the personnel of a psychiatric hospital].

    abstract::The prevalence of Hepatitis B Virus (HBV) markers was studied in 350 staff members from a Psychiatric Hospital, where a high prevalence of HBV markers was observed among patients. The prevalence of HBsAg, anti-HBs plus anti-HBc, anti-HBc alone and anti-HBs alone were determined to be: 2%, 15.1%, 4% and 0.3%, respectiv...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

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  • [Clinical study on the use of methergoline for the inhibition of lactation during the puerperium].

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    pub_type: 杂志文章

    doi:

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    abstract:: ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:10.23736/S0026-4806.19.06100-7

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  • [Arterial hypertension as a medico-social disease. Etiopathogenetic aspects and therapeutic possibilities].

    abstract::The increased incidence of arterial hypertension raises important medicosocial problems, since it has been shown that the prognosis for those who receive treatment is different from that of those who do not. Mass education is required to ensure that as many sufferers are aware of their condition before complications s...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

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    更新日期:1977-02-21 00:00:00

  • [Echocardiographic study in congestive cardiomyopathy].

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    pub_type: 杂志文章

    doi:

    authors: Alcini E,Beltrami M,Tripi M,Megna R,Stio F

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  • [Clinico-statistical considerations on the agreement between echographic and biopsy findings in hepatopathies of the diffuse type].

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    doi:

    authors: Cusumano S,De Mori E,Buschini M,Carugati A,Farina F

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