Abstract:
:A study has been made of the mechanism of action of intradiscal injections of preparations of chymopapain in the treatment of sciatica. Such preparations were found to contain at least four distinct proteins, but enzymatically active chymopapain was the component mainly responsible for releasing glycosaminoglycan from cartilaginous tissue. Previous suggestions that an electrostatic interaction between chymopapain and glycosaminoglycan is important to the action of injected enzyme were not supported by the finding that both positively and negatively charged forms of chymopapain efficiently released glycosaminoglycan from cartilaginous tissue. In contrast, cysteine alone did not cause release of glycosaminoglycan. Chymopapain was found to be inhibited efficiently by the protein inhibitors, cystatin C and low molecular weight kininogen in vitro, and the possible relevance of this finding to the efficacy and safety of chemonucleolysis is discussed.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Buttle DJ,Abrahamson M,Barrett AJdoi
10.1097/00007632-198609000-00006subject
Has Abstractpub_date
1986-09-01 00:00:00pages
688-94issue
7eissn
0362-2436issn
1528-1159journal_volume
11pub_type
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