Development of a prosthetic intervertebral disc.

Abstract:

:This article is a preliminary report of a 10-year investigation of the development of an intervertebral disc prosthesis. Spinal fusion is a method for the treatment of chronic, disabling low-back pain that does not respond to nonoperative treatments. Spinal fusion, however, has various adverse effects, and the results of spinal fusion are often unpredictable. The goal of this research project was to develop disc prostheses that have mechanical properties very similar to those of natural, normal discs. Two types of disc prosthesis, one with fiber-reinforced polyurethane and the other with multicomponent, non-fiber-reinforced polymers (C-Flex), have been designed and manufactured. The fiber-reinforced disc was made of polyurethane end-plates with A100 hardness, a homogenous nucleus with A40, and 12 layers of multidirectional (0, +45 degrees), fiber-reinforced anulus with A40 polyurethane. The design and modeling of the multicomponent polymers (non-fiber-reinforced) was made of C-Flex endplates with A90 hardness, a nucleus with A35 occupying 35% of the volume, and an anulus with 70A. Mechanical testing of these disc prostheses demonstrated similar mechanical properties to those of natural, normal discs.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Lee CK,Langrana NA,Parsons JR,Zimmerman MC

doi

10.1097/00007632-199106001-00015

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

S253-5

issue

6 Suppl

eissn

0362-2436

issn

1528-1159

journal_volume

16

pub_type

杂志文章

相关文献

SPINE文献大全
  • Preservation of thoracic kyphosis is critical to maintain lumbar lordosis in the surgical treatment of adolescent idiopathic scoliosis.

    abstract:STUDY DESIGN:Retrospective analysis of prospectively collected multicenter series. OBJECTIVE:To evaluate the sagittal profile of surgically treated adolescent idiopathic scoliosis (AIS) patients. SUMMARY OF BACKGROUND DATA:With the increasing popularity of segmental pedicle screw spinal instrumentation, thoracic kyph...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181dccd63

    authors: Newton PO,Yaszay B,Upasani VV,Pawelek JB,Bastrom TP,Lenke LG,Lowe T,Crawford A,Betz R,Lonner B,Harms Study Group.

    更新日期:2010-06-15 00:00:00

  • A rationalized approach to physiotherapy for low-back pain.

    abstract::A systematic approach to low-back pain is presented that relies on the classification of patients according to their symptoms. Rational systems of physiotherapy are proposed for each group and incorporated into an algorithmn. One hundred forty-two patients with mechanical low-back pain have been treated, and their res...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198507000-00012

    authors: Sikorski JM

    更新日期:1985-07-01 00:00:00

  • Depression is associated with a poorer outcome of lumbar spinal stenosis surgery: a two-year prospective follow-up study.

    abstract:STUDY DESIGN:Prospective clinical study. OBJECTIVE:To investigate the effect of depressive symptoms on the surgery outcome on 2-year follow-up among lumbar spinal stenosis (LSS) patients. SUMMARY OF BACKGROUND DATA:Previous research has suggested an association between preoperative depressive symptoms and a poorer su...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181dcaf4a

    authors: Sinikallio S,Aalto T,Airaksinen O,Lehto SM,Kröger H,Viinamäki H

    更新日期:2011-04-15 00:00:00

  • Prophylactic stabilization of vertebral body metastasis at risk of imminent fracture using balloon kyphoplasty.

    abstract:STUDY DESIGN:Case report. OBJECTIVE:Presentation of the previously unreported technique of balloon kyphoplasty being used to prophylactically stabilize a vertebral body metastasis at risk of imminent fracture. SUMMARY OF BACKGROUND DATA:Many patients with spinal metastases are not suitable for a total en bloc resecti...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181a482f6

    authors: Langdon J,Bernard J,Molloy S

    更新日期:2009-06-01 00:00:00

  • Patterns of care for low back pain in a working population.

    abstract:STUDY DESIGN:A prospective longitudinal study with 1-year follow-up. SUMMARY OF BACKGROUND DATA:Little is known about the consequences of having back pain and the patterns underlying the decisions to use medical care. OBJECTIVES:The aim of this study is to describe care utilization for low back pain (LBP) and to inve...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000127188.58944.1e

    authors: IJzelenberg W,Burdorf A

    更新日期:2004-06-15 00:00:00

  • Cervical stability after sequential capsule resection.

    abstract::A portion of the cervical facet joint must be resected to expose and decompress cervical nerve roots from a posterior approach. When posterior fusion is performed, it is common to remove the facet capsule only for the joints being fused. This study was performed to examine the effect of resection of the facet capsule ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199310001-00013

    authors: Zdeblick TA,Abitbol JJ,Kunz DN,McCabe RP,Garfin S

    更新日期:1993-10-15 00:00:00

  • Posterior Only Approach for Lumbar Pyogenic Spondylitis With Short Instrumentation and Prolonged Suction Drainage.

    abstract:STUDY DESIGN:A single-institution, single-surgeon retrospective review. OBJECTIVE:To assess the efficacy of posterior only approach with short instrumentation and prolonged suction drainage in managing lumbar pyogenic spondylitis. SUMMARY OF BACKGROUND DATA:Several methods of posterior surgical treatment for pyogenic...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001566

    authors: Kim YM,Choi SM

    更新日期:2016-09-01 00:00:00

  • Coexistence of cervical and lumbar disc disease.

    abstract::A retrospective analysis of 200 patients requiring cervical disc surgery was performed to determine the frequency of coexistent lumbar disc or spine abnormalities. The duration of follow-up ranged from 5 to 25 years, averaging 14 years. Sixty percent were women and 40% were men, their ages ranging from 25-73 years. An...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199012000-00006

    authors: Jacobs B,Ghelman B,Marchisello P

    更新日期:1990-12-01 00:00:00

  • Interaction of 5-hydroxytryptamine and tumor necrosis factor-α to pain-related behavior by nucleus pulposus applied on the nerve root in rats.

    abstract:STUDY DESIGN:The effects of exogenous 5-hydroxytryptamine (5-HT), tumor necrosis factor(TNF)-α, 5-HT + TNF in combination, and autologous nucleus pulposus (NP) at dorsal root ganglion (DRG) were examined using rat models. OBJECTIVE:To examine the interaction of 5-HT with TNF for pain-related behavior in a rat lumbar d...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181fea618

    authors: Kobayashi H,Kikuchi S,Konno S,Kato K,Sekiguchi M

    更新日期:2011-02-01 00:00:00

  • Anterior vertebral screw strain with and without solid interspace support.

    abstract:STUDY DESIGN:This in vitro biomechanical study examines segmental anterior vertebral screw strain and solid rod construct stiffness with and without the addition of multilevel, threaded cortical bone dowels in a bovine model. OBJECTIVE:To determine whether strain at the bone-screw interface is higher at the end levels...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200011010-00007

    authors: Spiegel DA,Cunningham BW,Oda I,Dormans JP,McAfee PC,Drummond DS

    更新日期:2000-11-01 00:00:00

  • The natural history of age-related disc degeneration: the pathology and sequelae of tears.

    abstract:STUDY DESIGN:A quasi 3-dimensional pathologic survey of tears in the L4-L5 disc. OBJECTIVE:To seek accurate information on the pathogenesis and outcomes of tears to facilitate correlation with radiologic imaging and biomechanical testing; and to improve laboratory models for testing hypotheses of disc function and fai...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31815b64d2

    authors: Vernon-Roberts B,Moore RJ,Fraser RD

    更新日期:2007-12-01 00:00:00

  • The reliability of the lateral radiograph in determination of the optimal transarticular C1-C2 screw length.

    abstract:STUDY DESIGN:This study assessed the value of using lateral radiographs in evaluating the optimal screw length in transarticular C1-C2 screw fixation. OBJECTIVES:To assess the reliability of the lateral radiograph in determining the optimal transarticular C1-C2 screw length. SUMMARY OF BACKGROUND DATA:Transarticular ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199810150-00009

    authors: Xu R,Ebraheim NA,Misson JR,Yeasting RA

    更新日期:1998-10-15 00:00:00

  • Comorbid subjective health complaints in low back pain.

    abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVES:To compare subjective health complaints in subacute patients with low back pain with reference values from a Norwegian normal population. SUMMARY OF BACKGROUND DATA:Comorbidity is common with nonspecific low back pain. We wanted to investigate if these complaints were sp...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000219947.71168.08

    authors: Hagen EM,Svensen E,Eriksen HR,Ihlebaek CM,Ursin H

    更新日期:2006-06-01 00:00:00

  • Different arm positions and the shape of the thoracic spine can explain contradictory results in the literature about spinal loads for sitting and standing.

    abstract:STUDY DESIGN:Loads acting in vivo on a vertebral body replacement (VBR) and the shape of the back were measured. OBJECTIVE:To find an explanation for the contradictory results in literature regarding spinal loads for sitting and standing. SUMMARY OF BACKGROUND DATA:In several in vivo studies, the intradiscal pressure...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181d55d52

    authors: Dreischarf M,Bergmann G,Wilke HJ,Rohlmann A

    更新日期:2010-10-15 00:00:00

  • Predicting Neurologic Recovery after Surgery in Patients with Deficits Secondary to MESCC: Systematic Review.

    abstract:STUDY DESIGN:Systematic literature review and expert survey OBJECTIVE.: The aim of this study was to determine factors associated with neurologic improvement in patients with neurologic deficits secondary to metastatic epidural spinal cord compression (MESCC). Clear understanding of these factors will guide surgical de...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0000000000001827

    authors: Laufer I,Zuckerman SL,Bird JE,Bilsky MH,Lazáry Á,Quraishi NA,Fehlings MG,Sciubba DM,Shin JH,Mesfin A,Sahgal A,Fisher CG

    更新日期:2016-10-15 00:00:00

  • The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures.

    abstract:STUDY DESIGN:A biomechanical study comparing two materials for augmentation of osteoporotic vertebral bodies and vertebral bodies after compression fracture. OBJECTIVES:To compare an injected, biodegradable calcium phosphate bone substitute with injected polymethylmethacrylate bone cement for strengthening osteoporoti...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199908010-00004

    authors: Bai B,Jazrawi LM,Kummer FJ,Spivak JM

    更新日期:1999-08-01 00:00:00

  • Unusual back pain caused by intervertebral disc degeneration associated with schmorl node at Th11/12 in a young athlete, successfully treated by anterior interbody fusion: a case report.

    abstract:STUDY DESIGN:A case report describing thoracic intervertebral disc degeneration and spondylolisthesis associated with a Schmorl node in a young athlete, which was successfully treated by anterior interbody fusion (AIF). OBJECTIVE:To describe a rare pathologic condition with a clinical outcome of a surgical interventio...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318198c60cXXX

    authors: Fukuta S,Miyamoto K,Iwata A,Hosoe H,Iwata H,Shirahashi K,Shimizu K

    更新日期:2009-03-01 00:00:00

  • Three-year incidence of low back pain in an initially asymptomatic cohort: clinical and imaging risk factors.

    abstract:STUDY DESIGN:Prospective cohort study of randomly selected Veterans Affairs out-patients without baseline low back pain (LBP). OBJECTIVE:To determine predictors of new LBP as well as the 3-year incidence of magnetic resonance imaging (MRI) findings. SUMMARY OF BACKGROUND DATA:Few prospective studies have examined cli...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000167536.60002.87

    authors: Jarvik JG,Hollingworth W,Heagerty PJ,Haynor DR,Boyko EJ,Deyo RA

    更新日期:2005-07-01 00:00:00

  • A reduction-fixation system for unstable thoracolumbar burst fractures.

    abstract::Thirty-three patients with unstable burst fractures of the lower thoracic and lumbar spine were treated with a reduction-fixation system. The new system is used both as a reduction and a fixation device for disorders of the lower thoracic and lumbar spine. In treatment of spinal fractures, it provides symmetric lordot...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199208000-00004

    authors: Chang KW

    更新日期:1992-08-01 00:00:00

  • A Computed Tomography Study of the C7 Vertebra Screws Fixation in Children.

    abstract:STUDY DESIGN:Retrospective analysis of computed tomographic images of 92 normal pediatric cervical vertebrae. OBJECTIVE:The aim of this study was to ascertain the feasibility of the pedicle, intralaminar, and lateral mass screws fixation in children. SUMMARY OF BACKGROUND DATA:Fixation techniques of C7 vertebrae are ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002742

    authors: Liu J,Ji W,Huang Z,Kong G,Liu Q,Huang Z,Wu X,Zhu Q

    更新日期:2018-12-15 00:00:00

  • Anabolic effects of Peniel 2000, a peptide that regulates TGF-β1 signaling on intervertebral disc degeneration.

    abstract:STUDY DESIGN:An in vitro study with bovine intervertebral disc (IVD) cells and an in vivo study with a rabbit disc degeneration model on the extracellular matrix metabolism by a biglycan-derived peptide (Peniel 2000; P2K). OBJECTIVE:To investigate the mechanism for P2K-induced increases in extracellular matrix and in ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31827aa896

    authors: Kwon YJ,Lee JW,Moon EJ,Chung YG,Kim OS,Kim HJ

    更新日期:2013-01-15 00:00:00

  • Spinal motion after cervical fusion. In vivo assessment with roentgen stereophotogrammetry.

    abstract:STUDY DESIGN:A roentgen stereophotogrammetric (RS) technique using metallic markers was used to determine in vivo three-dimensional (3-D) motion data in the post-operative cervical spine. Two patients were examined with RS following fusion for up to 12 months at scheduled intervals. OBJECTIVES:The study was designed t...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199410150-00015

    authors: Lee S,Harris KG,Goel VK,Clark CR

    更新日期:1994-10-15 00:00:00

  • Lumbar paraspinal compartment syndrome. A case report with physiologic and anatomic studies.

    abstract::A 24-year-old man presented with severe low-back pain and paraspinal muscle spasm after exertion. Elevation in temperature, white blood cell count, serum muscle enzymes, and urine myoglobin, as well as computer tomographic evidence of paraspinal muscle edema and necrosis, were present. No etiology could be documented,...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Carr D,Gilbertson L,Frymoyer J,Krag M,Pope M

    更新日期:1985-11-01 00:00:00

  • The influence of distraction force on the intradiscal pressure gradient in the bridged lumbar spine: a biomechanical investigation using a calf model.

    abstract:STUDY DESIGN:A biomechanical calf cadaver study. OBJECTIVE:The purpose of this study was to determine the intradiscal pressure gradient of bridged healthy intervertebral segments in correlation with intraoperative distraction force. SUMMARY OF BACKGROUND DATA:Bisegmental dorsal stabilization and anatomic reduction is...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000213

    authors: Spiegl U,Pätzold R,Glasmacher S,Stephan D,Josten C,Bühren V,Gonschorek O,Augat P

    更新日期:2014-04-01 00:00:00

  • Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy.

    abstract:STUDY DESIGN:To demonstrate the existence of mesenchymal stem cells (MSCs) in ligamentum flavum (LF) and their pathogenic role in LF hypertrophy. OBJECTIVE:To isolate and characterize LF-derived MSCs and their response to transforming growth factor-beta 1 (TGF-β1) and trichostatin A (TSA), a histone deacetylase inhibi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3182053f58

    authors: Chen YT,Wei JD,Wang JP,Lee HH,Chiang ER,Lai HC,Chen LL,Lee YT,Tsai CC,Liu CL,Hung SC

    更新日期:2011-08-15 00:00:00

  • Abnormal skeletal growth patterns in adolescent idiopathic scoliosis--a longitudinal study until skeletal maturity.

    abstract:STUDY DESIGN:A cross-sectional and prospective longitudinal study on the anthropometric parameters and growth pattern of girls with adolescent idiopathic scoliosis (AIS). OBJECTIVE:To investigate the growth pattern of girls with AIS with different severities, using cross-sectional and prospective longitudinal data set...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31825c036d

    authors: Yim AP,Yeung HY,Hung VW,Lee KM,Lam TP,Ng BK,Qiu Y,Cheng JC

    更新日期:2012-08-15 00:00:00

  • Value of immediate preprocedure magnetic resonance imaging in patients scheduled to undergo vertebroplasty or kyphoplasty.

    abstract:STUDY DESIGN:Retrospective case series. OBJECTIVE:To determine the incidence of additional vertebral compression fractures diagnosed with repeat MRI immediately before vertebroplasty or kyphoplasty. SUMMARY OF BACKGROUND DATA:Vertebral compression fractures, which occur frequently in the elderly, are more likely in p...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31819740bb

    authors: Benz BK,Gemery JM,McIntyre JJ,Eskey CJ

    更新日期:2009-03-15 00:00:00

  • Isolation and characterization of mesenchymal stromal cells from human degenerated nucleus pulposus: comparison with bone marrow mesenchymal stromal cells from the same subjects.

    abstract:STUDY DESIGN:To identify mesenchymal stromal cells (MSC) from degenerate human nucleus pulposus (NP) and compare them with bone marrow (BM) MSC. OBJECTIVE:To test whether MSC obtained from NP and BM from the same subjects share similar biologic characteristics. SUMMARY OF BACKGROUND DATA:Recent studies have proposed ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181cb8828

    authors: Blanco JF,Graciani IF,Sanchez-Guijo FM,Muntión S,Hernandez-Campo P,Santamaria C,Carrancio S,Barbado MV,Cruz G,Gutierrez-Cosío S,Herrero C,San Miguel JF,Briñon JG,del Cañizo MC

    更新日期:2010-12-15 00:00:00

  • The Optimal Timing of Hydrogel Injection for Treatment of Intervertebral Disc Degeneration: Quantitative Analysis Based on T1ρ MR Imaging.

    abstract:STUDY DESIGN:Animal experimental study. OBJECTIVE:The aim of this study was to investigate the optimal time of hydrogel injection for regenerating intervertebral disc degeneration (IDD) based on T1ρ magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA:Currently, different approaches are being pursued to regen...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003667

    authors: Liu Z,Li J,Hu M,Wang X,Chen N,Cui S,Li S,Liu H,Chen G,Pan X,Sun H,Liu S,Wei F

    更新日期:2020-11-15 00:00:00

  • The access randomized clinical trial of public versus private physiotherapy for low back pain.

    abstract:STUDY DESIGN:Pragmatic randomized clinical trial. OBJECTIVE:This study investigated differences in the clinical outcomes of public physiotherapy (public PT) versus private physiotherapy (private PT) for general practitioner-referred patients with acute and chronic low back pain (LBP). SUMMARY OF BACKGROUND DATA:Healt...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/BRS.0b013e3182127457

    authors: Casserley-Feeney SN,Daly L,Hurley DA

    更新日期:2012-01-15 00:00:00