Abstract:
STUDY DESIGN:A quasi 3-dimensional pathologic survey of tears in the L4-L5 disc. OBJECTIVE:To seek accurate information on the pathogenesis and outcomes of tears to facilitate correlation with radiologic imaging and biomechanical testing; and to improve laboratory models for testing hypotheses of disc function and failure. SUMMARY OF BACKGROUND DATA:Tears are evidence of structural failure involving the anulus. There are substantial differences in the structure and function of the anterior and posterior anulus and the nonlamellar "nucleus" is much smaller than generally conceptualized and modeled. METHOD:Microscopy of sections prepared from 5-mm-thick parallel sagittal slices of 70 L4-L5 discs was used to construct maps of tears in each slice and record other features of interest. A template was used to classify data for analysis. RESULTS:Multiple-level analysis detected 20% more tears than in a single disc section. Concentric, perinuclear, and radiating tears often appeared first in the posterior disc and were numerous throughout life. However, rim lesions, transdiscal tears, endplate separations, and Schmorl's nodes were infrequent in young discs. Rim lesions and transdiscal tears markedly increased in the older discs while the other tears showed modest growth. In elderly discs, many tears acquired blood vessels accompanied by nerves capable of transmitting pain. Apart from about 15% of rim lesions, healing of tears by scar tissue was absent. Links between various types of tears result in complex discographic images from older discs and the cavitation of transdiscal tears lead to segmental instability. CONCLUSION:Tears in the L4-L5 disc show different patterns of incidence with aging, which can be explained by current biomechanical concepts. Tears may not only perturb disc function and cause segmental instability, but the frequency of neovascularization accompanied by neoinnervation indicates that pain originating within the degenerate disc should not be dismissed as the frequent evidence of bleeding into the tear lumen indicates the susceptibility of the vessels to trauma.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Vernon-Roberts B,Moore RJ,Fraser RDdoi
10.1097/BRS.0b013e31815b64d2subject
Has Abstractpub_date
2007-12-01 00:00:00pages
2797-804issue
25eissn
0362-2436issn
1528-1159pii
00007632-200712010-00004journal_volume
32pub_type
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