Abstract:
STUDY DESIGN:Behavior, mRNA and immunohistochemical assessment of the expression of fractalkine (CX3CL1) and its receptor (CX3CR1) in a rat model of disc herniation by autologous nucleus pulposus (NP) implantation. OBJECTIVE:To evaluate the changes in expression of fractalkine and its receptor in the spinal cord and their association with pain behavior in a rat model of disc herniation. SUMMARY OF BACKGROUND DATA:Chemokines have recently been implicated in the pathophysiology of neuropathic pain. They mediate astrocytic migration and microglial proliferation, which are involved in the regulation of nociceptive transmission. Fractalkine is a chemokine, which participates in the mechanisms of neuropathic pain as a mediator of neuron-glia interactions. METHODS:Sixty-six rats (NP-treated = 47, sham = 19) were implanted with autologous NP (approximately 3 mg) on the left L5 nerve root, just proximal to the dorsal root ganglion and tested for thermal hyperalgesia and mechanical allodynia before surgery and on days 1, 5, 10, 20, and 30 after surgery. The changes of expression of fractalkine and its receptor in the spinal cord were studied using real time PCR and immunohistochemistry. RESULTS:Rats developed ipsilateral mechanical allodynia at day 1 and bilateral thermal hyperalgesia at day 5 after surgery, and these changes in sensitivity persisted throughout the observation period. The expression of mRNA for fractalkine in the spinal cord was increased by day 5 and remained upregulated for the duration of the experiment. The immunostaining for fractalkine increased in neurons and astrocytes and that for the fractalkine receptor increased in microglia in the dorsal horn ipsilateral to the disc herniation. CONCLUSION:Our results indicate that autologous implantation of NP induces thermal hyperalgesia and mechanical allodynia, and leads to an upregulation of fractalkine and its receptor in spinal neurons and glia, implicating fractalkine in association with radicular pain.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Park HW,Ahn SH,Kim SJ,Seo JM,Cho YW,Jang SH,Hwang SJ,Kwak SYdoi
10.1097/BRS.0b013e3181ef610bsubject
Has Abstractpub_date
2011-05-20 00:00:00pages
E753-60issue
12eissn
0362-2436issn
1528-1159journal_volume
36pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:Case report. OBJECTIVE:To report a case of lumbar intraneural hemorrhagic cyst after anticoagulation therapy that caused progressive radiculopathy and cauda equina syndrome. The possible pathogenic mechanism, associated diseases, and treatment options are discussed. SUMMARY OF BACKGROUND DATA:Various pat...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31829e1440
更新日期:2013-09-15 00:00:00
abstract:STUDY DESIGN:Literature review. OBJECTIVES:To assess the frequency of lumbar fusion procedures in the United States; changes in the incidence of fusion in the past 12 years; variations in fusion procedure rates among geographic regions of the nation and between the United States and other countries; costs of lumbar fu...
journal_title:Spine
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-15 00:00:00
abstract:STUDY DESIGN:Combined prospective randomized controlled trial and observational cohort study of intervertebral disc herniation (IDH), an as-treated analysis. OBJECTIVE:To determine modifiers of the treatment effect (TE) of surgery (the difference between surgical and nonoperative outcomes) for intervertebral disc hern...
journal_title:Spine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/BRS.0b013e3182276b2b
更新日期:2012-01-15 00:00:00
abstract:STUDY DESIGN:Literature review. OBJECTIVE:To determine characteristics and trends in published spine research over a recent decade in a high impact, general orthopedic surgery journal. SUMMARY OF BACKGROUND DATA:Recent trends in published spine research in a high-impact orthopedic surgery journal are unknown. Such kn...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0000000000003189
更新日期:2020-01-15 00:00:00
abstract:STUDY DESIGN:Magnetic resonance images of cervical compression myelopathy were retrospectively analyzed in comparison with surgical outcomes. OBJECTIVES:To investigate which magnetic resonance findings in patients with cervical compression myelopathy reflect the clinical symptoms and prognosis, and to determine the ra...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200106010-00012
更新日期:2001-06-01 00:00:00
abstract:STUDY DESIGN:We performed a retrospective review of 126 cases of infectious spondylodiscitis over a 4-year period. OBJECTIVE:Differentiation between pyogenic spondylodiscitis (PS) and tuberculous spondylodiscitis (TS) is essential for deciding on the appropriate therapeutic regimen. The aim of this study was to compar...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181e04dd3
更新日期:2010-10-01 00:00:00
abstract:STUDY DESIGN:This study retrospectively, reviewed the effects of pedicle screw fixation on lumbosacral fusion for degenerative conditions. The records and radiographs of a group of patients treated by wide decompression and fusion of the lumbosacral spine and by one surgeon were studied. Two treatment groups were ident...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199509150-00014
更新日期:1995-09-15 00:00:00
abstract::Chylothorax as a complication of anterior thoracic spine fusion is described in the case of a male with congenital kyphosis. Treatment with protracted chest tube drainage was required, along with dietary modification in which fat ingestion was restricted. This complication is reported to occur in 0.2% of intrathoracic...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:STUDY DESIGN:The authors prospectively evaluated 40 patients with paralytic scoliosis treated from 1985 to 1990 with bilateral posterior segmental instrumentation, facet fusions, local bone graft, and allograft (mostly fresh frozen) bone supplementation only. OBJECTIVES:The authors report the fusion results for these ...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::An electronic digital inclinometer was used to obtain normative data on cervical mobility from 58 normal subjects. They consisted of 28 males (age range, 17-61) and 30 females (age range, 19-62). The measurements were taken from occiput to T1 in flexion-extension, lateral bend, and axial rotation, isolating the region...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199311000-00007
更新日期:1993-11-01 00:00:00
abstract::This study examined the role of facet joint morphology in the etiology of both degenerative spondylolisthesis and isthmic spondylolysis. To this end, the axial facet joint morphology of the lower lumbar spine in a normal population and in populations of patients with spinal stenosis or degenerative spondylolisthesis a...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:STUDY DESIGN:A prospective cohort study. OBJECTIVE:To evaluate the effects of epidural steroid injections (ESIs) on blood glucose levels in patients with diabetes mellitus. SUMMARY OF BACKGROUND DATA:ESIs are commonly used in the treatment of multiple spinal disorders. Corticosteroid injections have been evaluated in...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/BRS.0b013e31821fd21f
更新日期:2012-01-01 00:00:00
abstract:STUDY DESIGN:We measured the expression and responses of Toll-Like Receptor 4 (TLR4) activation in the intervertebral disc (IVD) in vitro and in vivo. We hypothesize that stimulation of the IVD with the TLR4 ligand lipopolysaccharide (LPS) results in upregulation of a coordinated set of proinflammatory mediators and in...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31826b71f4
更新日期:2013-07-15 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:We report a case of a 16-year-old boy with intermittent and migratory polyarthralgia, who made a diagnostic dilemma. SUMMARY OF BACKGROUND DATA:Spinal involvement without spinal symptom in gout seems to be rare. However, the relationship of spinal gout to symptoms is poorly underst...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002403
更新日期:2018-04-15 00:00:00
abstract:STUDY DESIGN:A prospective cohort study. OBJECTIVE:To establish outcome measures for recovery and chronic pain for studies with patients who present with recent-onset acute low back pain (LBP) in primary care. SUMMARY OF BACKGROUND DATA:Among back pain researchers, no consensus exists about outcome definitions or how...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31820c01a6
更新日期:2011-12-15 00:00:00
abstract:STUDY DESIGN:Review article. OBJECTIVES:To identify decision-making principles for selecting fusion levels in adult spinal deformity, with particular attention to lumbar curves and double major curves. SUMMARY OF BACKGROUND DATA:Although numerous articles have been published on the selection of fusion levels for adol...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/01.brs.0000236023.08226.90
更新日期:2006-09-01 00:00:00
abstract:STUDY DESIGN:Prospective randomized comparison of anterior lumbar interbody fusion (ALIF) plus transpedicular instrumentation plus posterolateral fusion (PLF) (360 degrees fusion) to ALIF plus transpedicular instrumentation without PLF (270 degrees fusion). OBJECTIVES:To compare the clinical outcomes, costs, and utili...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-200105150-00019
更新日期:2001-05-15 00:00:00
abstract:STUDY DESIGN:Cross-sectional study with repeated measures design. OBJECTIVE:To compare the myosin heavy-chain isoform distribution within and between paraspinal muscles and to test the theory that fiber-type gradients exist as a function of paraspinal muscle depth. SUMMARY OF BACKGROUND DATA:There is still uncertaint...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181bfcd98
更新日期:2010-06-01 00:00:00
abstract:STUDY DESIGN:Multicenter, prospective, consecutive clinical series. OBJECTIVE.: To report on the use and outcomes of preoperative magnetic resonance imaging (MRI) in a prospective cohort study of 2206 children undergoing posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis. SUMMARY OF BACKGR...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e3181da218c
更新日期:2011-04-15 00:00:00
abstract::The purpose of this study was to assess the natural history of sciatica due to lumbosacral nerve root compromise and to evaluate the pathomorphologic changes that accompany the natural resolution of the disease. One hundred sixty-five consecutive patients, 114 males and 51 females, with an average age of 41 years (ran...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199210000-00013
更新日期:1992-10-01 00:00:00
abstract:STUDY DESIGN:In-vitro study of the tissue mechanics of annulus fibrosus. OBJECTIVE:To determine the effect of axial torsion on the mechanical properties of the inter- and intralamellar matrices. SUMMARY OF BACKGROUND DATA:Axial torsion, when combined with repetitive flexion, has been associated with an increased risk...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002803
更新日期:2019-02-15 00:00:00
abstract:STUDY DESIGN:A biomechanical cadaveric study in lumbar calf spine. OBJECTIVE:Evaluation of the effects of selected degrees of freedom (df) on the dynamic stabilization of the spine in terms of segmental range of motion (RoM), center of rotation (CoR), and implant loadings. SUMMARY OF BACKGROUND DATA:For dorsal stabil...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000702
更新日期:2015-02-01 00:00:00
abstract::Low back pain (LBP) is the most common, costly, and disabling musculoskeletal condition. Although most LBP patients recover within two months, 2-3% eventually develop disabling chronic low back pain (DCLBP). Due to the prevalence of DCLBP problems, models have been developed to predict which acute low back pain patien...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199306150-00023
更新日期:1993-06-15 00:00:00
abstract:STUDY DESIGN:Systematic review. OBJECTIVE:To determine the effects of acupuncture for individuals with neck pain. SUMMARY OF BACKGROUND DATA:Neck pain is one of the 3 most frequently reported complaints of the musculoskeletal system. Treatments for neck pain are varied, as are the perceptions of benefits. METHODS.: W...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/01.brs.0000252100.61002.d4
更新日期:2007-01-15 00:00:00
abstract:STUDY DESIGN:A prospective double-blind randomized trial in 31 patients. OBJECTIVES:To assess the clinical efficacy of percutaneous radiofrequency denervation of the lumbar zygapophysial joints in reducing pain, functional disability, and physical impairment in patients with back pain originating from the lumbar zygap...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-199909150-00013
更新日期:1999-09-15 00:00:00
abstract:STUDY DESIGN:A 7-year-old ambulatory girl with complete bilateral agenesis of the ilium is reported. OBJECTIVE:To document the clinical evolution and the spino-pelvic balance of a girl with bilateral agenesis of the ilium. SUMMARY OF BACKGROUND DATA:Scapuloiliac dysostosis is a rare focal skeletal dysplasia consistin...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000169448.58989.a1
更新日期:2005-07-15 00:00:00
abstract:STUDY DESIGN:Herniated lumbar disc specimens were cocultured with peripheral blood mononuclear cells, and cells isolated from extruded disc were cultured to study the production of matrix metalloproteinases. OBJECTIVE:To investigate the role of peripheral blood mononuclear cells infiltrating extruded discs and disc-de...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200107150-00004
更新日期:2001-07-15 00:00:00
abstract:STUDY DESIGN:Prospective clinical study. OBJECTIVE:To assess Health-Related Quality of Life outcomes in patients undergoing surgery for spinal metastases. SUMMARY OF BACKGROUND DATA:Increasing life expectancy of patients with spinal metastases has resulted in greater interest in overall quality of life, including pai...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/01.brs.0000245838.37817.40
更新日期:2006-11-15 00:00:00
abstract:STUDY DESIGN:Anulus fibrosus (AF) cells obtained from patients undergoing surgery were cocultured with macrophage-like cells and production of inflammatory mediators was analyzed by quantitative assay. OBJECTIVE:To investigate the role of macrophages in AF cell production of inflammatory mediators by cytokines stimula...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318182c35f
更新日期:2008-10-01 00:00:00
abstract:STUDY DESIGN:We demonstrated the differentiation of notochordal cells by direct observation using a live automated cell imaging system. We also hypothesized that notochordal cells have characteristics of chondrocyte-like cells. OBJECTIVE:To determine characteristics of notochordal cells by matrix protein expression an...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181b26ed1
更新日期:2009-11-01 00:00:00