Abstract:
:Eighty-five samples of chorionic villi from women undergoing prenatal diagnosis at 8 to 12 weeks' gestation were subjected to cytogenetic analysis. Samples were prepared by a direct technique that permits limited analysis within two hours and by a short-term culture technique that permits detailed structural analysis within one week. An adequate number of cell divisions for cytogenetic analysis was obtained from 96% of living fetuses. Using both the direct technique and short-term culture, satisfactory banded chromosomal preparations were made in 93% of cases. Eleven of 12 pregnancies (92%) shown by ultrasound to be dead shortly before sampling, had cytogenetic abnormalities. Further studies are needed to develop banding definition equivalent to that available on cultured amniocytes.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Vekemans MJ,Perry TBdoi
10.1007/BF00290954subject
Has Abstractpub_date
1986-04-01 00:00:00pages
307-10issue
4eissn
0340-6717issn
1432-1203journal_volume
72pub_type
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