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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin.

Abstract：

:Modification of the 2(S)-methylbutyryl moiety of mevinolin led to a series of side chain ester derivatives. A systematic exploration of the structure-activity relationships showed that the introduction of an additional aliphatic group on the carbon alpha to the carbonyl group increased potency. This observation led to the synthesis of compound 16, which has about 2.5 times the intrinsic inhibitory activity of mevinolin.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Hoffman WF,Alberts AW,Anderson PS,Chen JS,Smith RL,Willard AK

doi

10.1021/jm00155a040

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

849-52

issue

5

eissn

0022-2623

issn

1520-4804

journal_volume

29

pub_type

杂志文章

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