The association between age and adverse events due to biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A retrospective cohort study.

Abstract:

ABSTRACT:We examined whether the age of patients with rheumatoid arthritis was associated with adverse events (AEs) caused by biologic disease-modifying antirheumatic drugs (bDMARDs).Patients with rheumatoid arthritis using bDMARDs from Showa University Hospital, Showa University Northern Yokohama Hospital, and Showa University Koto Toyosu Hospital from January 2005 to December 2017 were eligible for this retrospective cohort study. The maximum observation period was determined to be 1 year. Outcomes in patients older and younger than 75 years were compared. The primary outcome was the rate of drug discontinuation because of AEs caused by bDMARDs. Univariate and multivariate analyses were performed using Pearson's chi-squared test and logistic regression analysis, respectively.A total of 416 patients were enrolled; median (interquartile range [IQR]): 60.0 (44.3 - 71.0) years and 84.6% women; patients ≥ 75 years were 67/416 (16.1%). The rates of drug discontinuation because of AEs caused by bDMARDs were 10.5% (7/67) in patients 75 years and older and 10.9% (38/349) in those younger than 75 years (relative risk 0.95, 95% confidential interval 0.45-2.24). In logistic regression analysis adjusted for covariates, the rate of drug discontinuation showed no significant difference between the patients ≥ 75 years and the those < 75 years (adjusted odds ratio 0.70, 95% confidential interval 0.29-1.75, P = .45).The rate of drug discontinuation because of AEs caused by bDMARDs was not significantly different between patients 75 years and older and patients younger than 75 years.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Ikari Y,Yajima N,Miwa Y

doi

10.1097/MD.0000000000023861

subject

Has Abstract

pub_date

2020-12-24 00:00:00

pages

e23861

issue

52

eissn

0025-7974

issn

1536-5964

pii

00005792-202012240-00062

journal_volume

99

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Strategic use of dual regimens of boosted protease inhibitors plus maraviroc in poorly adherent subjects in view of long-acting drugs: A retrospective study.

    abstract::In view of the forthcoming long-acting antiretrovirals, measures should be taken to prevent the selection of HIV drug resistance mutations. All subjects who had been switched to boosted protease inhibitors plus maraviroc (bPIs/MVC) with baseline HIV-1 RNA >50 copies/mL between June, 2014, and April, 2015, were retrosp...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005728

    authors: Capetti AF,Micale M,Carenzi L,Niero F,Landonio S,Vimercati S,Dedivitiis G,Rizzardini G

    更新日期:2017-02-01 00:00:00

  • Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China.

    abstract::The aim of this study was to elucidate the possible association between migration inhibitory factor (MIF)-173G/C gene polymorphisms and transcript and plasma levels of MIF in spinal tuberculosis (TB) patients. Clinical data were collected from 254 spinal TB patients and 262 healthy controls participating in the study....

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021331

    authors: Wang J,Sheng B,Li X,Sun J,Shi L,Wei W,Wang G,Cao X

    更新日期:2020-07-24 00:00:00

  • Effectiveness of extracorporeal shock-wave therapy for frozen shoulder: A protocol for a systematic review of randomized controlled trial.

    abstract:BACKGROUND:This systematic review aims to explore the effectiveness and safety of extracorporeal shock-wave therapy (ESWT) for patients with frozen shoulder. METHODS:The sources of Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Web of Science,...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000014506

    authors: Cao DZ,Wang CL,Qing Z,Liu LD

    更新日期:2019-02-01 00:00:00

  • Association of cytokine gene polymorphisms with chronic hepatitis C virus genotype 1b infection in Chinese Han population: An observational study.

    abstract::Cytokines are extensively involved in the process of hepatitis C virus (HCV) infection and take a crucial part in host immune regulation. We aimed to explore the potential correlation of cytokine single nucleotide polymorphisms (SNPs) with HCV susceptibility and response rate of interferon (IFN)-based antiviral therap...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022362

    authors: Jing JS,Wang ZQ,Jiang YK,Zhang XY,Jiang WM

    更新日期:2020-09-18 00:00:00

  • Serum Ferritin Levels Are Positively Associated With Metabolically Obese Normal Weight: A Nationwide Population-Based Study.

    abstract::The purpose of this study was to examine the relationship between serum ferritin levels and metabolically obese normal weight (MONW) and to determine the appropriate cut-off value of serum ferritin for the prediction of clinical metabolic status in nonobese Korean adults. Data from 9411 participants in the fourth (200...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002335

    authors: Kim JW,Kim DH,Roh YK,Ju SY,Nam HY,Nam GE,Kim DW,Lee SH,Lee CW,Han K,Park YG

    更新日期:2015-12-01 00:00:00

  • Prevalence of chronic disease and its controlled status according to income level.

    abstract::The relationship between the prevalence of chronic diseases and income level has now become a main theme in poor national economic situations. We examined the prevalence of well-controlled chronic diseases according to income level. Data from the 2008 to 2014 Korea National Health and Nutrition Examination Survey, con...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005286

    authors: Kim S,Lee B,Park M,Oh S,Chin HJ,Koo H

    更新日期:2016-11-01 00:00:00

  • Comparison Between Ultrasound-Guided Supraclavicular and Interscalene Brachial Plexus Blocks in Patients Undergoing Arthroscopic Shoulder Surgery: A Prospective, Randomized, Parallel Study.

    abstract::Although supraclavicular brachial plexus block (SCBPB) was repopularized by the introduction of ultrasound, its usefulness in shoulder surgery has not been widely reported. The objective of this study was to compare motor and sensory blockades, the incidence of side effects, and intraoperative opioid analgesic require...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000001726

    authors: Ryu T,Kil BT,Kim JH

    更新日期:2015-10-01 00:00:00

  • Pneumothorax associated with nontuberculous mycobacteria: A retrospective study of 69 patients.

    abstract::The incidence of nontuberculous mycobacterial pulmonary disease (NTMPD) is increasing worldwide. Secondary spontaneous pneumothorax occurs as a complication of underlying lung disease and is associated with higher morbidity, mortality, and recurrence than primary spontaneous pneumothorax. We here investigated the clin...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004246

    authors: Ueyama M,Asakura T,Morimoto K,Namkoong H,Matsuda S,Osawa T,Ishii M,Hasegawa N,Kurashima A,Goto H

    更新日期:2016-07-01 00:00:00

  • Effect of high-flow nasal cannula oxygen therapy vs conventional oxygen therapy on adult postcardiothoracic operation: A meta-analysis.

    abstract:INTRODUCTION:The effect of high-flow nasal cannula (HFNC) on adult post cardiothoracic operation remains controversial. We conducted a meta-analysis of randomized controlled trials to evaluate the effect of HFNC and conventional oxygen therapy (COT) on postcardiothoracic surgery. METHODS:A search was conducted in Emba...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000012783

    authors: Wu X,Cao W,Zhang B,Wang S

    更新日期:2018-10-01 00:00:00

  • Tongue diagnosis indices for gastroesophageal reflux disease: A cross-sectional, case-controlled observational study.

    abstract::Traditional Chinese medicine tongue diagnosis can mirror the status of the internal organ, but evidence is lacking regarding the accuracy of tongue diagnosis to gastroesophageal reflux disease (GERD). This study was to investigate the association between GERD and tongue manifestation, and whether tongue imaging could ...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/MD.0000000000020471

    authors: Wu TC,Lu CN,Hu WL,Wu KL,Chiang JY,Sheen JM,Hung YC

    更新日期:2020-07-17 00:00:00

  • Preoperative Volume-Based PET Parameter, MTV2.5, as a Potential Surrogate Marker for Tumor Biology and Recurrence in Resected Pancreatic Cancer.

    abstract::This study aims to evaluate the role of volume-based positron emission tomography parameters as potential surrogate markers for tumor recurrence in resected pancreatic cancer. Between January 2008 and October 2012, medical records of patients who underwent surgical resection for pancreatic ductal adenocarcinoma and co...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002595

    authors: Kang CM,Lee SH,Hwang HK,Yun M,Lee WJ

    更新日期:2016-03-01 00:00:00

  • Non-α-fetoprotein-producing adrenal hepatoid adenocarcinoma: A case report and literature review.

    abstract:RATIONALE:Adrenal hepatoid adenocarcinoma typically secretes alpha-fetoprotein (AFP). Here, we report a case of non-AFP-producing adrenal hepatoid adenocarcinoma. Next-generation sequencing (NGS) was conducted to identify gene mutations. PATIENT CONCERNS:A 64-year-old man presented with mild back pain and unexplained ...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000012336

    authors: Lin J,Cao Y,Yu L,Lin L

    更新日期:2018-09-01 00:00:00

  • Prognostic comparison between mucinous and nonmucinous adenocarcinoma in colorectal cancer.

    abstract::Mucinous adenocarcinoma (MAC) is a histological subtype of colorectal cancer. The oncologic behavior of MAC differs from nonmucinous adenocarcinoma (non-MAC). Our aim in this study was to characterize patients with colorectal MAC through evaluation of a large, institutional-based cohort with long-term follow-up. A tot...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000658

    authors: Park JS,Huh JW,Park YA,Cho YB,Yun SH,Kim HC,Lee WY,Chun HK

    更新日期:2015-04-01 00:00:00

  • Elevated Serum PCT in Septic Shock With Endotoxemia Is Associated With a Higher Mortality Rate.

    abstract::To examine the effect of endotoxemia on the procalcitonin (PCT) serum levels and mortality rates of adult patients with septic shock diagnosed on the day of admission to the intensive care unit (ICU).A retrospective observational study was performed over a 2-year period. Levels of PCT were compared for septic shock pa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001085

    authors: Adamik B,Smiechowicz J,Jakubczyk D,Kübler A

    更新日期:2015-07-01 00:00:00

  • Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report.

    abstract:RATIONALE:Primary squamous cell carcinoma (SCC) of the stomach is a rare disease. The pathogenesis and prognosis of advanced SCC remains to be elucidated. The aim of the current study was to investigate the prognosis of recurrent or metastatic SCC of the stomach. PATIENT CONCERNS:A retrospective study examined the cli...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009224

    authors: Meng Y,Zhang J,Wang H,Zhang Y,Sun R,Zhang Z,Gao F,Huang C,Zhang S

    更新日期:2017-12-01 00:00:00

  • Development and internal validation of a novel model and markers to identify the candidates for lymph node metastasis in patients with prostate cancer.

    abstract:BACKGROUND:High-grade prostate cancer (PCa) has a poor prognosis, and up to 15% of patients worldwide experience lymph node invasion (LNI). To further improve the prediction lymph node invasion in prostate cancer, we adopted risk scores of the genes expression based on the nomogram in guidelines. METHODS:We analyzed c...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016534

    authors: Cao HM,Wan Z,Wu Y,Wang HY,Guan C

    更新日期:2019-07-01 00:00:00

  • Efficacy of furosemide for treatment of liver cirrhosis: A systematic review protocol of randomized controlled trial.

    abstract:BACKGROUND:Previous clinical studies have reported that furosemide can be used to treat liver cirrhosis (LC) effectively. However, no study systematically explored this issue. This systematic review aims to investigate the efficacy and safety of furosemide for treatment of LC. METHODS:This study will be conducted thro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015300

    authors: Zhu ZR,Liu WL,Ding ZM,Li Y

    更新日期:2019-04-01 00:00:00

  • Cardiac Autonomic Function in Patients With Ankylosing Spondylitis: A Case-Control Study.

    abstract::Ankylosing spondylitis (AS) is a chronic inflammatory disease involing spine and enthesis. The primary aim of this study is to investigate the autonomic nervous system (ANS) function and the association between ANS and the functional status or disease activity in AS.The study included 42 AS patients, all fulfilling th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003749

    authors: Wei CY,Kung WM,Chou YS,Wang YC,Tai HC,Wei JC

    更新日期:2016-05-01 00:00:00

  • Mobile health, physical activity, and obesity: Subanalysis of a randomized controlled trial.

    abstract:BACKGROUND:Recent studies on physical activity were analyzed by randomizing participants into either the intervention or control group. It is necessary to classify each intervention and control groups according to physical activity using the International Physical Activity Questionnaire (IPAQ). METHODS:This was a pilo...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000012309

    authors: Lee CH,Cheung B,Yi GH,Oh B,Oh YH

    更新日期:2018-09-01 00:00:00

  • Pulmonary edema following shoulder arthroscopy under general anesthesia with nerve block: An observational study.

    abstract:ABSTRACT:Shoulder arthroscopy requires a large of irrigation for a better surgical view, leading circulatory overload. This study was performed to prove whether pulmonary edema will be lead by a large of irrigation.General anesthesia with interscalene block was induced before operation. The primary outcome was ultrasou...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023713

    authors: Zhang G,Wan Q,Huang X,Shui Y,Luo C,Su L,Jiang X,Zhang L

    更新日期:2020-12-18 00:00:00

  • Effect of sub-hypothermia blood purification technique in cardiac shock after valvular disease surgery.

    abstract::To observe the effect of sub-hypothermia (HT) blood purification technique in the treatment of cardiac shock after heart valve disease.The patients were randomly divided into normothermic (NT) continuous blood purification (CBP) group (NT group) and HT CBP group (HT group). Observe the cardiac index (CI), the oxygen d...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000019476

    authors: Fang J,Xu M,Liu B,Wang B,Ren H,Yang H,Dong Y,Song L,Xiao H

    更新日期:2020-03-01 00:00:00

  • Acupuncture for uterine fibroids: Protocol for a systematic review of randomized controlled trials.

    abstract:BACKGROUND:Uterine fibroids represent the most common gynecological benign tumors in reproductive females. Acupuncture has been applied as a therapeutic modality in China to treat uterine fibroids. However, currently, few critical systematic reviews regarding the effect of acupuncture on uterine fibroids have been publ...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000014631

    authors: Liu T,Yu J,Kuang W,Wang X,Ye J,Qiu X,Xi W,Zeng Y,Zou H,Liu Y

    更新日期:2019-02-01 00:00:00

  • The syndrome of inappropriate antidiuretic hormone secretion (SIADH): pathophysiologic mechanisms in solute and volume regulation.

    abstract::1. Studies on eight patients were performed to clarify the mechanism(s) of altered sodium metabolism and volume regulation in SIADH. The mechanism controlling water excretion was also studied to determine whether there is evidence that altered osmoregulation may be the basis for inappropriate ADH secretion in some pat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-197905000-00004

    authors: Cooke CR,Turin MD,Walker WG

    更新日期:1979-05-01 00:00:00

  • Reduning injection combined with western medicine for pneumonia: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Pneumonia is a common respiratory disease. In severe cases, it can induce cardiovascular disease and even life-threatening. In particular, pneumonia caused by the new coronavirus (SARS-CoV-2) that broke out at the end of 2019 has seriously affected the health of people in all countries. In recent years, it h...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000022757

    authors: Cao C,Zhen Z,Kuang S,Xu T

    更新日期:2020-10-23 00:00:00

  • Trends in Outcomes for Out-of-Hospital Cardiac Arrest by Age in Japan: An Observational Study.

    abstract::Population aging has rapidly advanced throughout the world and the elderly accounting for out-of-hospital cardiac arrest (OHCA) has increased yearly.We identified all adults who experienced an out-of-hospital cardiac arrest in the All-Japan Utstein Registry of the Fire and Disaster Management Agency, a prospective, po...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002049

    authors: Fukuda T,Ohashi-Fukuda N,Matsubara T,Doi K,Kitsuta Y,Nakajima S,Yahagi N

    更新日期:2015-12-01 00:00:00

  • Allogeneic blood transfusion in 163 children with acute lymphocytic leukemia (a STROBE-compliant article).

    abstract::Little research has been done about the effects of allogeneic blood transfusion (ABT) on the recurrence and prognosis in the cases with childhood acute lymphocytic leukemia (cALL). In order to provide a basis for clinical safe blood transfusion, the data of 163 cases with cALL were retrospectively analyzed to explore ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014518

    authors: Wang D,Zhou G,Mao ST,Chen J,Liu YF

    更新日期:2019-02-01 00:00:00

  • Evidence for Chronic Kidney Disease-Mineral and Bone Disorder Associated With Metabolic Pathway Changes.

    abstract::Abnormalities in the levels of calcium, phosphorus, and parathyroid hormone (PTH) in serum are typical for patients with chronic kidney disease (CKD). They are used routinely to predict the onset of CKD-mineral and bone disorder (MBD). However, CKD-MBD associated with metabolic pathway imbalance is not well understood...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001273

    authors: Wu Q,Lai X,Zhu Z,Hong Z,Dong X,Wang T,Wang H,Lou Z,Lin Q,Guo Z,Chai Y

    更新日期:2015-08-01 00:00:00

  • A new intensive conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with refractory or relapsed acute myeloid leukemia.

    abstract::To explore the efficacy, and safety of the intensive conditioning regimen consisting of cladribine, cytarabine (Ara-C), and granulocyte colony-stimulating factor (G-CSF) plus modified busulfan (Bu) combined with cytoxan (Cy) (BuCy), prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients wi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010228

    authors: Wang J,Zhao J,Fei X,Yin Y,Cheng H,Zhang W,Gu J,Yang F,Yang Y,Xue S,Tian Z,He J,Zhang S,Wang X

    更新日期:2018-04-01 00:00:00

  • Anti-HMGCR autoantibodies in European patients with autoimmune necrotizing myopathies: inconstant exposure to statin.

    abstract::Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with NAM, especially in statin-ex...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000028

    authors: Allenbach Y,Drouot L,Rigolet A,Charuel JL,Jouen F,Romero NB,Maisonobe T,Dubourg O,Behin A,Laforet P,Stojkovic T,Eymard B,Costedoat-Chalumeau N,Campana-Salort E,Tournadre A,Musset L,Bader-Meunier B,Kone-Paut I,Sibilia

    更新日期:2014-05-01 00:00:00

  • Dementia Risk in Irradiated Patients With Head and Neck Cancer.

    abstract::Patients with head and neck cancer are treated through surgery, radiotherapy (RT), and chemotherapy (CT). Carotid artery damage and neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with l...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001983

    authors: Chen JH,Yen YC,Liu SH,Lee FP,Lin KC,Lai MT,Wu CC,Chen TM,Yuan SP,Chang CL,Wu SY

    更新日期:2015-11-01 00:00:00