Pulmonary emphysema is associated with fungal sensitization in asthma.

Abstract:

Background:Fungal sensitization is a risk factor for severe asthma. Colonization in the lower respiratory tract is one of the forms of fungal exposure, and it is related to fungal sensitization. Pulmonary emphysema was recently reported to be an underlying disease of fungal colonization. The aim of study was to evaluate the prevalence of pulmonary emphysema in asthmatic patients with and without fungal sensitization. Methods:We enrolled 108 patients with allergic asthma and divided them into the patients sensitized to Aspergillus and/or Candida (n=56) and those not sensitized to both Aspergillus and Candida (n=52). The presence of pulmonary emphysema on chest CT was evaluated retrospectively. Results:The frequency of pulmonary emphysema was significantly higher in the patients sensitized to Aspergillus and/or Candida compared to the patients not sensitized to both fungi (P=0.0040). The frequency of pulmonary emphysema was also significantly higher in the patients sensitized to either Aspergillus or Candida compared to the patient not sensitized to the fungi (P=0.0398 and P=0.0198, respectively). A multivariate logistic regression analysis demonstrated that the presence of pulmonary emphysema was independently associated with the sensitization to Aspergillus and/or Candida (OR 7.84, 95% CI: 1.20-51.10). Conclusions:Pulmonary emphysema is associated with sensitization to Aspergillus and/or Candida.

journal_name

J Thorac Dis

authors

Kono Y,To M,Tsuzuki R,Yamawaki S,Soeda S,To Y

doi

10.21037/jtd-20-995

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

5879-5886

issue

10

eissn

2072-1439

issn

2077-6624

pii

jtd-12-10-5879

journal_volume

12

pub_type

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