当前位置： SCI文献检索 > Genome Medicine期刊下所有文献 > DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.

DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.

Abstract：

BACKGROUND:One of the major challenges in obesity treatment is to explain the high variability in the individual's response to specific dietary and physical activity interventions. With this study, we tested the hypothesis that specific DNA methylation changes reflect individual responsiveness to lifestyle intervention and may serve as epigenetic predictors for a successful weight-loss. METHODS:We conducted an explorative genome-wide DNA methylation analysis in blood samples from 120 subjects (90% men, mean ± SD age = 49 ± 9 years, body mass-index (BMI) = 30.2 ± 3.3 kg/m2) from the 18-month CENTRAL randomized controlled trial who underwent either Mediterranean/low-carbohydrate or low-fat diet with or without physical activity. RESULTS:Analyses comparing male subjects with the most prominent body weight-loss (responders, mean weight change - 16%) vs. non-responders (+ 2.4%) (N = 10 each) revealed significant variation in DNA methylation of several genes including LRRC27, CRISP2, and SLFN12 (all adj. P < 1 × 10-5). Gene ontology analysis indicated that biological processes such as cell adhesion and molecular functions such as calcium ion binding could have an important role in determining the success of interventional therapies in obesity. Epigenome-wide association for relative weight-loss (%) identified 15 CpGs being negatively correlated with weight change after intervention (all combined P < 1 × 10- 4) including new and also known obesity candidates such as NUDT3 and NCOR2. A baseline DNA methylation score better predicted successful weight-loss [area under the curve (AUC) receiver operating characteristic (ROC) = 0.95-1.0] than predictors such as age and BMI (AUC ROC = 0.56). CONCLUSIONS:Body weight-loss following 18-month lifestyle intervention is associated with specific methylation signatures. Moreover, methylation differences in the identified genes could serve as prognostic biomarkers to predict a successful weight-loss therapy and thus contribute to advances in patient-tailored obesity treatment.

journal_name

Genome Med

journal_title

Genome medicine

authors

Keller M,Yaskolka Meir A,Bernhart SH,Gepner Y,Shelef I,Schwarzfuchs D,Tsaban G,Zelicha H,Hopp L,Müller L,Rohde K,Böttcher Y,Stadler PF,Stumvoll M,Blüher M,Kovacs P,Shai I

doi

10.1186/s13073-020-00794-7

subject

Has Abstract

pub_date

2020-11-16 00:00:00

pages

97

issue

1

issn

1756-994X

pii

10.1186/s13073-020-00794-7

journal_volume

12

pub_type

杂志文章

相关文献

Genome Medicine文献大全
  • Creating a data resource: what will it take to build a medical information commons?

    abstract：:National and international public-private partnerships, consortia, and government initiatives are underway to collect and share genomic, personal, and healthcare data on a massive scale. Ideally, these efforts will contribute to the creation of a medical information commons (MIC), a comprehensive data resource that is...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-017-0476-3

    authors： Deverka PA,Majumder MA,Villanueva AG,Anderson M,Bakker AC,Bardill J,Boerwinkle E,Bubela T,Evans BJ,Garrison NA,Gibbs RA,Gentleman R,Glazer D,Goldstein MM,Greely H,Harris C,Knoppers BM,Koenig BA,Kohane IS,La Rosa S,

    更新日期：2017-09-22 00:00:00

  • Moving pathogen genomics out of the lab and into the clinic: what will it take?

    abstract：:Pathogen genomic analysis is a potentially transformative new approach to the clinical and public-health management of infectious diseases. Health systems investing in this technology will need to build infrastructure and develop policies that ensure genomic information can be generated, shared and acted upon in a tim...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-015-0254-z

    authors： Luheshi LM,Raza S,Peacock SJ

    更新日期：2015-12-30 00:00:00

  • Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies.

    abstract：:Cutaneous malignancies, especially malignant melanoma, exhibit great genetic heterogeneity. As a result, some individuals and families have particularly increased risk due to genetic predisposition to the disease. The susceptibility alleles range from rarely occurring, heritable, high-risk variants to ubiquitously occ...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm95

    authors： Udayakumar D,Tsao H

    更新日期：2009-10-27 00:00:00

  • Defining functional signatures of dysbiosis in periodontitis progression.

    abstract：:Periodontitis is a common inflammatory disease that leads to tooth loss and has been linked to cardiovascular disease and diabetes mellitus. The periodontal microbiome is highly diverse, and metatranscriptomic studies have indicated that the genes that are expressed by the microbiota are more relevant than the microbi...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-015-0165-z

    authors： Wang GP

    更新日期：2015-04-27 00:00:00

  • The futility of genomic counseling: essential role of electronic health records.

    abstract：:Technological advances over the past several years have dramatically reduced the cost of whole-genome sequencing. At the same time, understanding of the functional significance of genetic variation has advanced considerably. The routine generation of whole-genome sequence data for individual patients will soon be suff...

    journal_title：Genome medicine

    pub_type： 社论

    doi：10.1186/gm48

    authors： Belmont J,McGuire AL

    更新日期：2009-05-08 00:00:00

  • Consensus: a framework for evaluation of uncertain gene variants in laboratory test reporting.

    abstract：:Accurate interpretation of gene testing is a key component in customizing patient therapy. Where confirming evidence for a gene variant is lacking, computational prediction may be employed. A standardized framework, however, does not yet exist for quantitative evaluation of disease association for uncertain or novel g...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm347

    authors： Crockett DK,Ridge PG,Wilson AR,Lyon E,Williams MS,Narus SP,Facelli JC,Mitchell JA

    更新日期：2012-05-28 00:00:00

  • Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations.

    abstract：BACKGROUND:Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its receptor interaction, thus obstructing the formation of new blood vessels. METHODS:A phase II rando...

    journal_title：Genome medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s13073-018-0601-y

    authors： Höglander EK,Nord S,Wedge DC,Lingjærde OC,Silwal-Pandit L,Gythfeldt HV,Vollan HKM,Fleischer T,Krohn M,Schlitchting E,Borgen E,Garred Ø,Holmen MM,Wist E,Naume B,Van Loo P,Børresen-Dale AL,Engebraaten O,Kristensen V

    更新日期：2018-11-29 00:00:00

  • Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.

    abstract：BACKGROUND:Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work led to the development of the widely use...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-019-0650-x

    authors： Phelan JE,O'Sullivan DM,Machado D,Ramos J,Oppong YEA,Campino S,O'Grady J,McNerney R,Hibberd ML,Viveiros M,Huggett JF,Clark TG

    更新日期：2019-06-24 00:00:00

  • Host genetic variation and its microbiome interactions within the Human Microbiome Project.

    abstract：BACKGROUND:Despite the increasing recognition that microbial communities within the human body are linked to health, we have an incomplete understanding of the environmental and molecular interactions that shape the composition of these communities. Although host genetic factors play a role in these interactions, these...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-018-0515-8

    authors： Kolde R,Franzosa EA,Rahnavard G,Hall AB,Vlamakis H,Stevens C,Daly MJ,Xavier RJ,Huttenhower C

    更新日期：2018-01-29 00:00:00

  • Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model.

    abstract：:The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by producing transparent, externally fertilized embryos. Embryonic zebrafish are easily visualized and ma...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm299

    authors： Martin CS,Moriyama A,Zon LI

    更新日期：2011-12-29 00:00:00

  • The three-body problem of therapy with induced pluripotent stem cells.

    abstract：:Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-015-0141-7

    authors： Tolar J,McGrath JA

    更新日期：2015-02-20 00:00:00

  • Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance.

    abstract：BACKGROUND:Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approa...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-017-0407-3

    authors： Duffy DJ,Krstic A,Halasz M,Schwarzl T,Konietzny A,Iljin K,Higgins DG,Kolch W

    更新日期：2017-02-10 00:00:00

  • Environment-driven somatic mosaicism in brain disorders.

    abstract：:The identification of somatic mosaicism in the brain lends a new perspective to our understanding of the role of gene and environment interactions in psychiatric disease risk. Somatic mutations, such as retrotransposon insertions, that are precipitated by modern environmental factors may alter neuronal function and ne...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-016-0317-9

    authors： Bedrosian TA,Linker S,Gage FH

    更新日期：2016-05-23 00:00:00

  • VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites.

    abstract：:The analysis of the genomic distribution of viral vector genomic integration sites is a key step in hematopoietic stem cell-based gene therapy applications, allowing to assess both the safety and the efficacy of the treatment and to study the basic aspects of hematopoiesis and stem cell biology. Identifying vector int...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-014-0067-5

    authors： Calabria A,Leo S,Benedicenti F,Cesana D,Spinozzi G,Orsini M,Merella S,Stupka E,Zanetti G,Montini E

    更新日期：2014-09-03 00:00:00

  • MeCP2 mutations: progress towards understanding and treating Rett syndrome.

    abstract：:Rett syndrome is a profound neurological disorder caused by mutations in the MECP2 gene, but preclinical research has indicated that it is potentially treatable. Progress towards this goal depends on the development of increasingly relevant model systems and on our improving knowledge of MeCP2 function in the brain. ...

    journal_title：Genome medicine

    pub_type： 信件,评审

    doi：10.1186/s13073-017-0411-7

    authors： Shah RR,Bird AP

    更新日期：2017-02-17 00:00:00

  • Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.

    abstract：BACKGROUND:A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome sequencing data for genotypic drug susceptibility testing (DST). METHODS:We investigated mutation...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00726-5

    authors： Merker M,Kohl TA,Barilar I,Andres S,Fowler PW,Chryssanthou E,Ängeby K,Jureen P,Moradigaravand D,Parkhill J,Peacock SJ,Schön T,Maurer FP,Walker T,Köser C,Niemann S

    更新日期：2020-03-06 00:00:00

  • Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells.

    abstract：BACKGROUND:Abnormal pre-mRNA splicing regulation is common in cancer, but the effects of chemotherapy on this process remain unclear. METHODS:To evaluate the effect of chemotherapy on slicing regulation, we performed meta-analyses of previously published transcriptomic, proteomic, phosphoproteomic, and secretome datas...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-018-0557-y

    authors： Anufrieva KS,Shender VО,Arapidi GP,Pavlyukov MS,Shakhparonov MI,Shnaider PV,Butenko IO,Lagarkova MA,Govorun VM

    更新日期：2018-06-27 00:00:00

  • Precision cancer mouse models through genome editing with CRISPR-Cas9.

    abstract：:The cancer genome is highly complex, with hundreds of point mutations, translocations, and chromosome gains and losses per tumor. To understand the effects of these alterations, precise models are needed. Traditional approaches to the construction of mouse models are time-consuming and laborious, requiring manipulatio...

    journal_title：Genome medicine

    pub_type： 杂志文章,评审

    doi：10.1186/s13073-015-0178-7

    authors： Mou H,Kennedy Z,Anderson DG,Yin H,Xue W

    更新日期：2015-06-09 00:00:00

  • Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation.

    abstract：BACKGROUND:Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized. METHODS:We comprehensively m...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00788-5

    authors： Liu S,Harmston N,Glaser TL,Wong Y,Zhong Z,Madan B,Virshup DM,Petretto E

    更新日期：2020-10-22 00:00:00

  • Genomics and the classification of mental illness: focus on broader categories.

    abstract：:Coinciding with the release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, two recently published molecular genetics analyses suggest large overlaps in genetic liability to schizophrenia, bipolar disorder and major depressive disorder. This indicates that a broader category of sever...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm501

    authors： Uher R

    更新日期：2013-10-25 00:00:00

  • Personalizing carbamazepine therapy.

    abstract：:The anticonvulsant carbamazepine has a high incidence of cutaneous adverse drug reactions. A recent prospective clinical trial in Taiwan has indicated that HLA-B*1502 screening will reduce the incidence of life-threatening adverse reactions to carbamazepine, while a genome-wide association study has identified the HLA...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm243

    authors： Mushiroda T,Nakamura Y

    更新日期：2011-05-30 00:00:00

  • The Human Gene Mutation Database: 2008 update.

    abstract：:The Human Gene Mutation Database (HGMD((R))) is a comprehensive core collection of germline mutations in nuclear genes that underlie or are associated with human inherited disease. Here, we summarize the history of the database and its current resources. By December 2008, the database contained over 85,000 different l...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm13

    authors： Stenson PD,Mort M,Ball EV,Howells K,Phillips AD,Thomas NS,Cooper DN

    更新日期：2009-01-22 00:00:00

  • The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.

    abstract：BACKGROUND:The R620W variant in protein tyrosine phosphatase non-receptor 22 (PTPN22) is associated with rheumatoid arthritis (RA). The PTPN22 gene has alternatively spliced transcripts and at least two of the splice forms have been confirmed to encode different PTPN22 (LYP) proteins, but detailed information regarding...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm301

    authors： Ronninger M,Guo Y,Shchetynsky K,Hill A,Khademi M,Olsson T,Reddy PS,Seddighzadeh M,Clark JD,Lin LL,O'Toole M,Padyukov L

    更新日期：2012-01-20 00:00:00

  • Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection.

    abstract：:Chronic infection with hepatitis B virus (HBV) occurs in approximately 6% of the world's population and carriers of the virus are at risk for hepatocellular carcinoma and cirrhosis. Current treatment regimens, which include interferon-alpha and nucleoside/nucleotide analogs, are only partially effective and new treatm...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm149

    authors： Weinberg MS,Arbuthnot P

    更新日期：2010-04-28 00:00:00

  • Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned.

    abstract：:Candidate gene association studies, linkage studies and genome-wide association studies have highlighted the role of genetic factors in the development of ischemic stroke. This research started over a decade ago, and can be separated into three major periods of research. In the first wave classic susceptibility marker...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm185

    authors： Maasz A,Melegh B

    更新日期：2010-09-13 00:00:00

  • Actionable gene-based classification toward precision medicine in gastric cancer.

    abstract：BACKGROUND:Intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (GC). To realize precision medicine for GC patients, an actionable gene alteration-based molecular classification that directly associates GCs with targeted therapies is needed. METHODS:A...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-017-0484-3

    authors： Ichikawa H,Nagahashi M,Shimada Y,Hanyu T,Ishikawa T,Kameyama H,Kobayashi T,Sakata J,Yabusaki H,Nakagawa S,Sato N,Hirata Y,Kitagawa Y,Tanahashi T,Yoshida K,Nakanishi R,Oki E,Vuzman D,Lyle S,Takabe K,Ling Y,Okuda

    更新日期：2017-10-31 00:00:00

  • Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation.

    abstract：:Tumor heterogeneity is of growing importance in the treatment of cancers. Mutational hot spots are prime locations for determining number and proportions of low variant allele frequency (VAF) tumor subclones by next generation sequencing. Low VAF detection is complicated by poor mapping efficiency in regions with high...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-015-0147-1

    authors： Spence JM,Spence JP,Abumoussa A,Burack WR

    更新日期：2015-03-12 00:00:00

  • Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe.

    abstract：BACKGROUND:Expression quantitative trait loci (eQTL) analysis is a powerful method to detect correlations between gene expression and genomic variants and is widely used to interpret the biological mechanism underlying identified genome wide association studies (GWAS) risk loci. Numerous eQTL studies have been performe...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-016-0320-1

    authors： Blauwendraat C,Francescatto M,Gibbs JR,Jansen IE,Simón-Sánchez J,Hernandez DG,Dillman AA,Singleton AB,Cookson MR,Rizzu P,Heutink P

    更新日期：2016-06-10 00:00:00

  • Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.

    abstract：:We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes as markers of donor identity. Instead, we take advantage of common single nucleotide polymorphisms,...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-018-0541-6

    authors： Chan Y,Chan YK,Goodman DB,Guo X,Chavez A,Lim ET,Church GM

    更新日期：2018-04-19 00:00:00

  • Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.

    abstract：BACKGROUND:Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. Whether this phenotype depends on strain or sex has never been systematically investigated on a large scale. Such effects, however, could lead to conflicts among studies, while further impacting st...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-017-0415-3

    authors： Swindell WR,Michaels KA,Sutter AJ,Diaconu D,Fritz Y,Xing X,Sarkar MK,Liang Y,Tsoi A,Gudjonsson JE,Ward NL

    更新日期：2017-03-09 00:00:00