Abstract:
:The anticonvulsant carbamazepine has a high incidence of cutaneous adverse drug reactions. A recent prospective clinical trial in Taiwan has indicated that HLA-B*1502 screening will reduce the incidence of life-threatening adverse reactions to carbamazepine, while a genome-wide association study has identified the HLA-A*3101 allele as a genetic risk factor for the full spectrum of carbamazepine-induced cutaneous adverse drug reactions in a European population. These studies should aid future decision-making for personalized use of carbamazepine treatment.
journal_name
Genome Medjournal_title
Genome medicineauthors
Mushiroda T,Nakamura Ydoi
10.1186/gm243subject
Has Abstractpub_date
2011-05-30 00:00:00pages
28issue
5issn
1756-994Xpii
gm243journal_volume
3pub_type
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