Standard management protocol to improve the short-term outcome of biliary atresia.

Abstract:

AIM:This study compared the outcomes of patients with biliary atresia (BA) treated according to a standardised protocol with historical patients. METHODS:This is a single-centred retrospective study of BA patients treated from 1980 to 2016. A standardised treatment protocol was established since 2008 regarding peri-operative management. The outcomes being compared between the two groups (Groups I and II = before and after 2008, respectively) were jaundice clearance (JC), incidence of recurrent cholangitis, hospital admission and native liver survival (NLS). RESULTS:A total of 128 patients were included (Group I = 100, Group II = 28). The overall median follow-up period was 15.3 years (I vs. II = 20.6 years vs. 5.1 years, respectively). There was no significant difference in the JC at the sixth month between the two groups (I vs. II = 60.0 vs. 82.1%, respectively, P = 0.07). The incidence of recurrent cholangitis was similar between the two groups (I vs. II = 39 vs. 35.7%, respectively, P = 0.45), but the median hospital admission episode per patient was non-significantly higher in Group I (I vs. II = 4.2 vs. 2.7, respectively, P = 0.08). There was an improvement in the 1-year NLS rate in Group II (I vs. II = 69.0 vs. 85.7%, respectively, P = 0.05). CONCLUSIONS:The introduction of a standardised management protocol has improved the short-term outcome of BA patients, with a better 1-year NLS observed.

authors

Chung PH,Wong KK,Tam PK

doi

10.1111/jpc.14698

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1774-1778

issue

11

eissn

1034-4810

issn

1440-1754

journal_volume

56

pub_type

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