Abstract:
:Environmental pollutants and nutrients may be present in the same foodstuffs or dietary patterns; share internal mechanisms of transport, metabolism and cellular uptake; or target the same molecular signalling pathways and biological functions. Lipophilic pollutants and nutrients, like dioxins and polyunsaturated fatty acids, may often converge at all aforementioned levels and thus the interactions become more likely. Despite this fact, the topic seems overlooked in mainstream epidemiological research. In this essay, we illustrate different levels of documented interactions between pollutants and nutrients with experimental, interventional and epidemiological evidence, paying special attention to lipophilic chemicals. We first describe common pollutants and nutrients encountered in diets and the internal lipophilic interface such as adipose tissue and serum lipids. Next, we discuss the preventive effects of nutrients against absorption and the toxic effects of pollutants, as well as the pollutant-induced perturbation of nutrient metabolism. Finally, we discuss the implications of nutrient-pollutant interactions in epidemiology, providing some examples of negative confounding, modification effect and statistical interactions reported for different outcomes including fetal growth, diabetes and cancer. The evidence discussed in this essay supports that the health impacts of chemicals have likely been underestimated due to the high risk of residual and coexposure confounding in diseases where interactions between pollutants and nutrients may occur.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Cano-Sancho G,Casas Mdoi
10.1136/jech-2020-213789subject
Has Abstractpub_date
2021-02-01 00:00:00pages
108-113issue
2eissn
0143-005Xissn
1470-2738pii
jech-2020-213789journal_volume
75pub_type
杂志文章abstract::This analysis attempts to fill the gap in the epidemiological evidence about the relation between dietary salt and hypertension. Changes in the purchase of salt in England and Wales are compared with changes in mortality from cerebrovascular disease (1958-78). Stroke mortality, a major sequel of hypertension, has decl...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.37.1.25
更新日期:1983-03-01 00:00:00
abstract:STUDY OBJECTIVE:The aim was to quantify the difference in precision of risk estimates in epidemiology between the situations where misclassification of exposure is corrected for by external validation and where it is corrected for by internal repeat measurement. Precision was measured in terms of the expected width of ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.46.6.620
更新日期:1992-12-01 00:00:00
abstract::The perinatal mortality rates of mothers who delivered at St. Thomas's Hospital from 1969 to 1976 have been examined. The rate in the West Indian population was significant higher than in the United Kingdom white population. The increased West Indian mortality was confined to infants with a birth weight of more than 2...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.36.1.22
更新日期:1982-03-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether methadone maintenance treatment (MMT) is effective in reducing the levels of HIV risk-taking behaviour (borrowing and lending of injection equipment, irregular condom use) among injecting drug users (IDUs), and to identify independent predictors of the borrowing of used syringes. D...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.50.5.534
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Literacy, the ability to access, understand and utilise information and concepts from diverse sources in ways that promote good outcomes is key to successful ageing. Domain-specific health and financial literacy are particularly relevant to older adults as they face increasingly complex health and financial ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-210977
更新日期:2019-03-01 00:00:00
abstract:STUDY OBJECTIVES:To describe the prevalence of hepatitis B virus (HBV) infection in patients with sexually transmitted diseases (STD) and human immunodeficiency virus (HIV) infection, and to determine the role of sexual transmission of HBV infection in Singapore. DESIGN:A cross sectional study of all consecutive men p...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.49.3.309
更新日期:1995-06-01 00:00:00
abstract::A prospective study of human reproduction was conducted in Tamilnadu State, South India, from 1969 to 1975. This paper reports twinning rates and relates these to maternal age, parity, and consanguinity. Birth weights and other dimensions at birth and infant mortality are also studied. The overall twinning rate was 1 ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.37.2.117
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:The authors assessed whether socioeconomic inequalities in asthma symptoms were already present in preschool children and to what extent prenatal, perinatal and postnatal risk factors for asthma symptoms mediate the effect of socioeconomic status (SES). METHODS:The study included 3136 Dutch children partici...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2011-200333
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:To assess the effects of neighbourhood level socioeconomic status (SES) and convenience store concentration on individual level smoking, after consideration of individual level characteristics. DESIGN:Individual sociodemographic characteristics and smoking were obtained from five cross sectional surveys (19...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2004.029041
更新日期:2005-07-01 00:00:00
abstract::A retrospective questionnaire and interview study of 10 year survivors of uncomplicated myocardial infarction examined smoking, diet, exercise, weight, medication, and treatment since discharge from hospital in 1973-4 and made comparisons with controls (using the same questionnaire) and with normal populations (as rep...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.40.2.103
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:This study examined whether living in rented housing is associated with increased all-cause and cause-specific mortality, and whether the association between home ownership and mortality can be explained by household income, occupational class, and educational level. METHODS:A random sample including every ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2007.061309
更新日期:2008-04-01 00:00:00
abstract::Factors affecting the attendance at primary health care clinics in Lagos were studied at Oguntolu Clinic and Randle Road Health Centre among 120 Nigerian children. The level of immunisation was a measure of the frequency (regularity) of attendance at the clinics. Certain socioeconomic, psychological, and demographic f...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.36.4.310
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVE:To compare a self administered computerised assessment of neurotic psychiatric disorder (psychiatric morbidity) with an identical assessment administered by a human interviewer. In particular, to discover whether a computerised assessment overestimates or underestimates the prevalence of psychiatric morbidity...
journal_title:Journal of epidemiology and community health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jech.48.2.207
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The aims of this study are to generalise the concept of gap length between partners and to estimate the duration of four types of measures for heterosexual partnerships, called status lengths: (1) time spent as single before becoming monogamous (S-M, positive gap), (2) duration of concurrency before monogamy...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2008.085936
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To estimate variation between small areas in the levels of walking, cycling, jogging, and swimming and overall physical activity and the importance of area level socioeconomic disadvantage in predicting physical activity participation. METHODS:All census collector districts (CCDs) in the 20 innermost local g...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2005.035931
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To determine the relative admission rates of Asian and non-Asian patients to intensive therapy units (ITUs) in Coventry and to explore the implications of these rates for the transplantation of organs to Asian people. DESIGN:Examination of 1991 census data and a retrospective review of ITU admissions books. ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.50.4.447
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Alcohol misuse, especially binge drinking in young people, and alcoholic liver disease are major public health concerns. However, alcohol misuse in older people is underestimated and often goes undetected. OBJECTIVE:To document alcohol consumption and clinical presentation of alcohol misuse in hospital inpa...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2005.043653
更新日期:2006-12-01 00:00:00
abstract::The Ottawa Charter has exerted a great deal of influence on the public health debate and on health promotion practices over the last 25 years. The Charter shifted the main focus from individual risk behaviours to social determinants of health, and introduced innovative strategies such as participatory processes and em...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2010.110437
更新日期:2010-06-01 00:00:00
abstract::This is the report of a feasibility study of a randomised controlled trial of chiropractic and hospital outpatient management for low back pain of mechanical origin. Preparations for the study included an approach to the General Medical Council for guidance about the intended collaboration between medically qualified ...
journal_title:Journal of epidemiology and community health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jech.40.1.12
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:To analyse in the general population the prevalence and predictors of symptomatology consistent with post-traumatic stress disorder (S-PTSD) 18 months after an industrial explosion. DESIGN:Cross-sectional survey. PARTICIPANTS AND OUTCOME MEASURES:A random sample of 1191 city inhabitants, including an oversa...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2006.057273
更新日期:2008-05-01 00:00:00
abstract::Age adjusted incidence rates (World standard) from invasive cervical cancer in the Swiss canton of Vaud decreased from 17.7/100,000 in 1968-70 to 9.9/100,000 in 1983-85. The decline was substantial in younger middle age, but no appreciable trend was observed in women over 70. This is consistent with available intervie...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.43.2.121
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Road traffic deaths (RTDs) remain the 9th most common cause of mortality in South Korea despite their decreasing trends in high-income countries. In 2010 and 2011, the Korean government deregulated the process for obtaining a driving licence, and there has been significant concern that such deregulation of t...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech-2015-207000
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The effects of six income types (household post-government income, Organisation for Economic Cooperation and Development-weighted household post-government income, individual net income, corrected monthly household income and household net income from wages) on subjective health were compared in order to exa...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2009.103390
更新日期:2011-06-01 00:00:00
abstract:STUDY OBJECTIVE:It has been frequently noted that overweight and obesity have a stronger relationship to hypertension and diabetes mellitus than to the risk of stroke. The reason for this observation has not been clear. This study aimed to examine the lifelong relation between body fat and stroke to shed light on why t...
journal_title:Journal of epidemiology and community health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jech.49.3.259
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:To assess the effect of growth during infancy and childhood on blood pressure in adolescence. DESIGN:Birth cohort study. SETTING:Pelotas, southern Brazil. PARTICIPANTS:749 adolescents with complete information on birth weight and gestational age, as well as on anthropometric data at all three follow up vis...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.57.3.226
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:To measure the geographical variation in prevalence of cardiovascular disease, risk factors, and their control in a nationally representative sample of older British women. METHODS:Baseline survey using general practitioner record review, a self completed questionnaire, research nurse interview, and physica...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.57.2.134
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To assess the short term health effects of improving housing. DESIGN:Randomised to waiting list. SETTING:119 council owned houses in south Devon, UK. PARTICIPANTS:About 480 residents of these houses. INTERVENTION:Upgrading houses (including central heating, ventilation, rewiring, insulation, and re-roofin...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2006.048462
更新日期:2007-09-01 00:00:00
abstract::Average paternal age in the UK is increasing. The public health implications of this trend have not been widely anticipated or debated. This commentary aims to contribute to such a debate. Accumulated chromosomal aberrations and mutations occurring during the maturation of male germ cells are thought to be responsible...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2005.045179
更新日期:2006-10-01 00:00:00
abstract:STUDY OBJECTIVE:To explore risk factors for symptomatic knee osteoarthritis (OAK) in women, which included wearing high heeled shoes. DESIGN:Matched case-control study. Exposure information obtained by interview, included details about past footwear. Self reported weight and height data obtained representing when wome...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.57.10.823
更新日期:2003-10-01 00:00:00
abstract::Infant mortality rates vary from area to area. Part of this variation is due to the socioeconomic characteristics of the area and part to other factors including the obstetric, paediatric, and community health services. Four social indicators associated with infant deaths are used to control for some of the variations...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.36.1.11
更新日期:1982-03-01 00:00:00