Abstract:
STUDY OBJECTIVE:To explore risk factors for symptomatic knee osteoarthritis (OAK) in women, which included wearing high heeled shoes. DESIGN:Matched case-control study. Exposure information obtained by interview, included details about past footwear. Self reported weight and height data obtained representing when women left school, were aged 36-40 and were aged 51-55. Regular work activities (including periods when homemaker or carer), smoking, and hormone related data gathered using a life-grid. SETTING:Interviews in participants' homes. Cases identified from orthopaedic hospital surgical waiting list, controls identified by general practitioners (GPs) PARTICIPANTS:Women aged 50 to 70 years. Cases awaiting knee replacement surgery. Controls, who had no past knee surgery and no knee pain in the past three years, were matched for age and GP. Altogether 111 eligible women were interviewed (29 cases, 82 controls). MAIN RESULTS:Univariate analyses identified several significant associations with OAK including past knee injury, arthritis of the feet, heavy smoking, being overweight (BMI 25 or above) and various occupational activities. Virtually all measures of high heeled shoes use were associated with reduced risk of OAK, although none of these findings were statistically significant. In multivariate analysis only BMI 25 or above at age 36-40 remained significantly associated with OAK (OR 36.4, 95% CI 3.07 to 432, p=0.004), although weak evidence suggested certain occupational activities might increase risk. Weight gain in early adult life was particularly pronounced among cases. CONCLUSIONS:Being overweight before the age of 40 considerably increased the risk of subsequent symptomatic OAK in women. Wearing high heeled shoes did not.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Dawson J,Juszczak E,Thorogood M,Marks SA,Dodd C,Fitzpatrick Rdoi
10.1136/jech.57.10.823keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
823-30issue
10eissn
0143-005Xissn
1470-2738journal_volume
57pub_type
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更新日期:2003-07-01 00:00:00
abstract:STUDY OBJECTIVE:A chemical spill from an oil refinery exposed the local community to more than 40,000 lb of highly toxic and corrosive hydrofluoric acid. A community based symptom prevalence study found an association between exposure and physical symptoms: the psychological impact of the disaster and its potential eff...
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doi:10.1136/jech-2013-202637
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更新日期:2004-05-01 00:00:00
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doi:10.1136/jech.34.1.14
更新日期:1980-03-01 00:00:00
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doi:10.1136/jech.37.1.25
更新日期:1983-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1136/jech.2008.077602
更新日期:2009-02-01 00:00:00
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doi:10.1136/jech-2013-202838
更新日期:2014-01-01 00:00:00
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更新日期:2019-02-01 00:00:00
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更新日期:2018-05-01 00:00:00
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/jech.48.4.391
更新日期:1994-08-01 00:00:00