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Mosaic chromosome 18 anomaly delineated in a child with dysmorphism using a three-pronged cytogenetic techniques approach: a case report.

Abstract：

BACKGROUND:A plethora of cases are reported in the literature with iso- and ring-chromosome 18. However, co-occurrence of these two abnormalities in an individual along with a third cell line and absence of numerical anomaly is extremely rare. CASE PRESENTATION:A 7-year-old female was referred for diagnosis due to gross facial dysmorphism and severe developmental delay. She presented with dysmorphic features, hypo/hyper pigmentation of the skin, intellectual disability and craniosynostosis. G-banding chromosome analysis suggested mos 46,XX,psu idic(18)(p11.2)[25]/46,XX,r(?18)[30]. Additional analysis by molecular karyotyping suggested pure partial deletion of 15 Mb on 18p (18p11.32p11.21). Lastly, multiple rearrangements and detection of a third cell line (ring chr18 and interstitial deletion) of chr18 was observed by multi-color banding. CONCLUSION:The current study presents a novel case of chromosomal abnormalities pertaining to chromosome 18 across 3 cell lines, which were delineated with a combinatorial approach of diagnostic methods.

journal_name

BMC Med Genomics

journal_title

BMC medical genomics

authors

Sheth H,Trivedi S,Liehr T,Patel K,Jain D,Sheth J,Sheth F

doi

10.1186/s12920-020-00796-9

subject

Has Abstract

pub_date

2020-09-24 00:00:00

pages

141

issue

1

issn

1755-8794

pii

10.1186/s12920-020-00796-9

journal_volume

13

pub_type

杂志文章

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