Abstract:
PURPOSE:This prospective, stratified, randomized, single-blind, placebo-controlled multicentre study investigated the safety and effectiveness of reducing blood loss and preventing venous thromboembolism (VTE) during posterior lumbar interbody fusion (PLIF) in patients with stenosis or spondylolisthesis using the combination of tranexamic acid (TXA) and rivaroxaban. METHODS:The Autar score was evaluated in patients after admission. Patients with an Autar score ≤ 10 were randomized to group A or B. Group A was the placebo-controlled group. Patients in group B were treated with 1 g TXA via intravenous injection and 1 g TXA for external use. Patients with an Autar score > 10 were randomized to group C or D. Patients in group C were treated with 10-mg rivaroxaban qd for 35 days after surgery. Patients in group D received the same treatment as those in group B intra-operatively and as those in group C post-operatively. RESULTS:A total of 599 patients from eight hospitals participated in this clinical trial. The total blood loss, intra-operative blood loss, and drainage volume were reduced by the administration of TXA (group A vs group B, P < 0.01; group C vs group D, P < 0.01), and the blood transfusion rate was also decreased (group A vs group B, P < 0.01; group C vs group D, P < 0.01). There were no significant differences (P > 0.05) in the VTE incidence rates among group A and group B. In patients with high-risk thrombosis, the number of patients with VTE was only three and seven after the application of rivaroxaban. Epidural haematoma was not discovered in any patients in our trial. CONCLUSION:The combined application of tranexamic acid and rivaroxaban significantly reduced the amount of blood loss and the transfusion rate during PLIF surgery and avoided an increase in the probability of thrombosis and the occurrence of epidural haematoma. TRIAL REGISTRATION NUMBER AND DATE OF REGISTRATION:ChiCTR-1800016430 2018-06-01.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Zhang L,Li Y,Liu D,Xiao X,Guan T,Yue H,Xue H,Zhou H,Jiao G,Wu W,Wang H,Liu H,Meng C,Sun Z,Chen Ydoi
10.1007/s00264-020-04699-3subject
Has Abstractpub_date
2020-10-01 00:00:00pages
2079-2087issue
10eissn
0341-2695issn
1432-5195pii
10.1007/s00264-020-04699-3journal_volume
44pub_type
杂志文章abstract::We have reviewed 29 cases of very unstable diaphyseal fractures of the femur in children and adolescents treated by Kuntscher nailing. Follow up was for at least 5 years, and in most cases until after the end of growth. There were no postoperative complications, and the mean overgrowth of the femur was 7.06 mm. There ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00186377
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:Osteoporosis mainly involves cancellous bone, and the spine and hip, with their relatively high cancellous bone to cortical bone ratio, are severely affected. Studies of bone mesenchymal stem cells (BMSCs) from osteoporotic patients and animal models have revealed that osteoporosis is often associated with redu...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1543-4
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Surgical management of humeral fractures associated with radial nerve palsy remains controversial. Some advocate surgical treatment in emergency while others recommend nonoperative treatment. PURPOSE:The aim of the study was to assess nerve recovery in a series of patients treated with open reduction and in...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-015-2745-3
更新日期:2015-08-01 00:00:00
abstract::Manipulation under anaesthesia (MUA) has been used to speed up recovery. However, the outcome of frozen shoulder after MUA in patients with diabetes has not been well documented in the past. A higher prevalence of frozen shoulder has been reported in diabetes mellitus (DM) patients. In this study, we revealed the shor...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-010-0968-x
更新日期:2010-12-01 00:00:00
abstract::In this study, 22 women patients with adult idiopathic scoliosis treated surgically with Cotrel-Dubousset instrumentation (CDI) or Texas Scottish Rite Hospital instrumentation (TSRHI) were followed up for 56.2+/-4.0 months. The overall immediate and final corrections were respectively 21.5+/-40 (58%) and 26.6+/-2.90 (...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-002-0346-4
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:The purpose of this study is to analyze the results using the USS fracture MIS system (DePuy Synthes) to treat instable pelvic ring fractures. As its outstanding feature, it is the only Schanz screw and rod system at present that combines angular stability, perforation/fenestration of the screws for cement-augm...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-3988-6
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:The rotator cuff concept refers to the four scapulohumeral muscles that stabilize and rotate the humerus relative to the scapula. To date, the first description of the rotator cuff remained unidentified. METHOD:In light of the 500th birthday of Andreas Vesalius (1515-1564) we searched his 1543 masterwork "Fabr...
journal_title:International orthopaedics
pub_type: 古典文章,历史文章,杂志文章
doi:10.1007/s00264-015-2823-6
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:The purpose of the study was to evaluate the treatment of five patients with proximal tibial epiphysis preserving resection for malignant tumours of the tibia. METHOD:Three patients suffered from Ewing sarcoma, two had osteosarcoma. The proximal level of the resection was in the line of the growth plate in fou...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-012-1731-2
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Avascular necrosis of the talus is one of the most notable complications associated with talar neck fractures with frequent evolution of the osteonecrosis into a difficult arthrodesis. We tested whether the injection of bone marrow mesenchymal stem cells (MSCs) could improve the repair process of the osteonecro...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-017-3716-7
更新日期:2018-12-01 00:00:00
abstract::In Japan, the main reason for osteoarthritis of the hip joint is caused by dysplastic deformities. The implantation technique of cementless press-fit cup with multi-screw fixation and acetabular bone graft to reconstruct the true acetabular center is described. In addition, special design aspects of the BiCONTACT-N st...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Following manipulation of frozen shoulders under general anaesthesia, we reviewed 74 shoulders at an average of 3 weeks and again at an average of 33 months following the manipulation. We used an adjusted Constant score by excluding the abduction strength measurement. The maximum score was therefore 75 points. The ave...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-002-0348-2
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:This review explores the scientific evidence for clinical, functional and imaging outcomes after surgical management of Femoroacetabular Impingement (FAI) syndrome, and assesses the methodological quality of the published literature reporting this issue. METHODS:The medical literature databases of Pubmed, Medl...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-011-1443-z
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Reconstruction of the medial patellofemoral ligament (MPFL) has become a popular procedure for patients with patellofemoral instability. Nevertheless, complication rates of up to 26 % have been reported. This study presents the analysis of failure and clinical outcome of subsequent revision surgery in young pat...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-014-2437-4
更新日期:2014-11-01 00:00:00
abstract::In the treatment of osteochondritis dissecans involving the elbow, we have used a bone-peg graft taken from the proximal part of the ulna and inserted into the defect. Thirty-two patients were followed from 2 to 10.5 years. The graft was utilised in 20 elbows, and 6 of these also had concomitant removal of a loose bod...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640050304
更新日期:1999-01-01 00:00:00
abstract::We describe fives cases of an unusual type of injury to the wrist which has been seen in Sikhs, an ethnic population in India. It is caused by entrapment of the kara, an iron bangle, which is traditionally worn as one of five compulsory religious symbols. The injuries were an open transtriquetral palmar perilunar disl...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00210533
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Heterotopic ossification (HO) may lead to complete elbow ankylosis, resulting in severe disability. The prognostic factors that may be valuable in guiding treatment of this condition have not yet been evaluated. The goals of this study were to describe the outcomes of open release for ankylosed elbow caused ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-016-3395-9
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To investigate the effect of C3/4 disc degeneration on cervical spondylosis with dizziness (CSD) and to assess the curative effect of anterior cervical decompression and fusion (ACDF) in patients with CSD. METHOD:Four hundred nineteen patients who underwent ACDF for treatment of myelopathy or radiculopathy wer...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04531-y
更新日期:2020-06-01 00:00:00
abstract::Bony defects caused by trauma, tumors, infection or congenital anomalies can present a significant surgical challenge. Free vascularised fibular bone grafts (FVFGs) have proven to be extremely effective in managing larger defects (longer than 6 cm) where other conventional grafts have failed. FVFGs also have a role in...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/s00264-014-2281-6
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine the location of the anterior humeral circumflex artery and axillary nerve based on bony landmarks, and to provide anatomical information that enables a safe approach when treating a proximal humeral fractures. METHODS:Thirty cadavers were included. The distances of bo...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-011-1394-4
更新日期:2012-04-01 00:00:00
abstract::Thirty six patients with a chronic slip of the capital femoral epiphysis and a femoral headneck angle of more than 30 degrees, as measured in a lateral radiograph, were treated by intertrochanteric osteotomy. The patients had an abnormal gait, an average age of 14.1 years and symptoms for an average of 14.5 months. Th...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00180203
更新日期:1992-01-01 00:00:00
abstract::A case of bilateral habitual dislocation of the patella associated with cleft lip and palate, and short metatarsals, metacarpals and phalanges is reported. The possible cause of habitual dislocation is discussed in the light of 20 cases which have been seen by the author. ...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00183358
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:The study aims to analyze the incidence of 30-day mortality in elderly patients who underwent surgery for hip fractures and its associated factors. METHODS:A prospective multicentric study was performed. All patients aged ≥ 65 years, with fragility hip fractures, consecutively admitted in two Italian hospitals...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-018-4057-x
更新日期:2019-02-01 00:00:00
abstract::This report is based upon a retrospective study of a consecutive series of twenty patients who had tuberculosis of the hip in quiescent state. Two patients had only a short history but were included in this study. An interesting feature at the time of operation was that in many cases the bone showed old features of tu...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/BF00266330
更新日期:1979-01-01 00:00:00
abstract::Four cases of the anterior interosseous nerve syndrome, which were treated by neurolysis, are added to the sixty-five already described in the literature. The onset of symptoms is usually spontaneous and electrophysiological examination is of value in making the diagnosis. The most frequent cause of the entrapment is ...
journal_title:International orthopaedics
pub_type: 杂志文章,评审
doi:10.1007/BF00268047
更新日期:1989-01-01 00:00:00
abstract::We used scanning electron microscopy to perform an ultrastructural analysis and two optical interferometric profilers to measure roughness on 40 prosthetic femoral heads. We expressed roughness as Ra (roughness average) value and Rsk (roughness skewness) value. Our results show that in order to obtain an ideal surface...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640000129
更新日期:2000-01-01 00:00:00
abstract::Between 1987 and 1999 we diagnosed and treated 110 patients with osteoid osteoma. Sixty patients were younger than 20 years. One hundred and four patients had characteristic pain at night. The mean duration of symptoms before surgery was 16 months. One hundred and four symptomatic patients were treated operatively wit...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s002640100231
更新日期:2001-01-01 00:00:00
abstract:PURPOSES:Acetabular fractures are more and more common in the elderly. Open reduction and internal fixation (ORIF) may lead to poor outcomes and high revision rates. Primary total hip arthroplasty (THA) combined with internal fixation, also known as the combined hip procedure (CHP), associated with dual mobility cup (D...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04757-w
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To compare the radiological and clinical outcomes of interlocking nail (ILN) and locking plate fixation (LCP) for humeral shaft fractures. METHODS:A total of 63 patients with displaced humeral shaft fractures between October 2014 and January 2017 were evaluated prospectively. They were divided randomly into tw...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-020-04696-6
更新日期:2020-10-01 00:00:00
abstract::Humeral shaft fractures respond well to conservative treatment and unite without much problem. Since it is uncommon, there is not much discussion regarding the management of nonunion in the literature, and hence this is a challenge to the treating orthopaedic surgeon. Osteoporosis of the fractured bone and stiffness o...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-008-0596-x
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:ADVANCE Medial Pivot (MP) (Wright Medical) total knee arthroplasty (TKA) was established to replicate normal tibio-femoral knee joint kinematics, however, its influence on the patello-femoral (PF) joint is unclear. The purpose in this study was to assess the PF joint conditions in Advance MP TKA, via radiograph...
journal_title:International orthopaedics
pub_type: 杂志文章
doi:10.1007/s00264-013-2043-x
更新日期:2014-03-01 00:00:00