Abstract：
:Previous studies focused on biocompatibility of graphene oxide (GO) to macrophages, but the impact of GO on lipid profiles in macrophages was less investigated. Herein, we investigated the interactions between THP-1 macrophages and GO of different sizes (GO of size 500-5000 nm, denoted as GO-L; GO of size < 500 nm, denoted as GO-S). We found that after 24 h exposure, the internalization of GO appeared to be minimal, whereas up to 50 μg/mL of GO-L but not GO-S reduced lipid accumulation, accompanying with a significantly reduced release of soluble monocyte chemoattractant protein-1 (MCP-1) but not interleukin-6 (IL-6). Moreover, lipidomic data showed that GO-L decreased the levels of 17 lipid classes, whereas GO-S only decreased the levels of 5 lipid classes. For comparison, 50 μg/mL carbon black (CB) significantly increased lipid accumulation with considerable particle internalization. GO-reduced lipid accumulation was not related with increase of reactive oxygen species (ROS) or induction of autophagy, and modulation of autophagy by chemicals showed no significant effect to alter the effects of GO-L on lipid accumulation. However, exposure to GO reduced the mRNA and protein levels of key components in peroxisome proliferators-activated receptor (PPAR) signaling pathway, a pathway that is related with lipid droplet biogenesis, and the modulation of PPARγ by chemicals altered the effects of GO-L on lipid accumulation. In conclusion, our results suggested that GO size-dependently altered lipid profiles in THP-1 macrophages that might be related with PPAR signaling pathway.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Luo Y,Peng J,Huang C,Cao Ydoi
10.1016/j.ecoenv.2020.110714subject
Has Abstractpub_date
2020-08-01 00:00:00pages
110714eissn
0147-6513issn
1090-2414pii
S0147-6513(20)30553-4journal_volume
199pub_type
杂志文章abstract：:Toxicokinetics and bioconcentration of eight common bisphenol analogues, including bisphenol A (BPA), -B, -C, -E, -S, -Z, -AF, and -AP in common carp (Cyprinus carpio) were investigated. Both free (BPfree) and total forms (BPtotal) of the bisphenols were measured in various fish tissues. The conjugated forms of bisphe...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.110183
更新日期：2020-03-15 00:00:00
abstract：:The reproduction of two closely related soil microarthropods, Folsomia candida Willem and Folsomia fimetaria L. (Insecta: Collembola), was tested under the influence of the insecticide dimethoate. Dimethoate had an adverse effect on the survival of adults and their reproduction in concentrations of about the recommend...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.1995.1020
更新日期：1995-03-01 00:00:00
abstract：:Cigarette smoke can affect female reproductive health by causing follicle destruction and oocyte dysfunction. Third-hand smoke has received increasing attention as a public health issue. However, the effects of third-hand smoke on the female reproductive system, particularly the ovaries, remain unclear. 1-(N-methyl-N-...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.109544
更新日期：2019-11-15 00:00:00
abstract：:The effect of humic acids (HAs) on the toxicity of copper, zinc, and lead was investigated using the photobacterium Vibrio fischeri (Microtox test) as a test organism. The effects of HAs on metal toxicity were evaluated as functions of time and concentration in pure compound solutions. The toxicities of copper and lea...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2005.04.005
更新日期：2006-01-01 00:00:00
abstract：:Methylmercury (MeHg) is transferred by female birds into their eggs thus leaving developing embryos exposed to MeHg from the time of fertilization through hatching. Although Hg is a developmental toxicant, little is known about how it distributes among embryonic tissues and subsequently affects neurodevelopment in bir...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2013.04.008
更新日期：2013-07-01 00:00:00
abstract：:Shorebirds were among birds exposed to Mississippi Canyon 252 (MC252) crude oil during the 2010 Deep Water Horizon (DWH) oil spill in the Gulf of Mexico. The western sandpiper (Calidris mauri) was chosen as one of four species for initial oral dosing studies conducted under Phase 2 of the avian toxicity studies for th...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2017.03.045
更新日期：2017-12-01 00:00:00
abstract：:Arbuscular mycorrhizal (AM) fungi can protect plants against cadmium (Cd) stress, and are the most prominent symbiotic fungi for contribution to phytoremediation. However, the tolerance mechanism for AM symbiosis on Cd toxicity still remains unclear, especially the related molecular mechanisms. In this study, differen...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.12.093
更新日期：2019-04-30 00:00:00
abstract：:In order to investigate pollution level, chemical speciation and health risk of exposure to heavy metals in street dust from smelting district, we carried the following studies: (a). the differences in the morphology of street dust in smelting and non-smelting districts using a scanning electron microscope; (b). the c...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.110617
更新日期：2020-07-01 00:00:00
abstract：:The cardio-respiratory function, oxidative stress and fish antioxidants were analyzed in juvenile Nile tilapia exposed for 96 h to a sublethal trichlorfon (TRC-Neguvon, Bayer) concentration of 0.5 mg L(-1). The exposure to TRC induced oxidative stress in the heart, as manifested by the glutathione S-transferase deplet...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2008.11.003
更新日期：2009-07-01 00:00:00
abstract：:Many unexplained fish-kills in British waters are considered microbial in origin and a large proportion of field sites contains elevated concentrations of filamentous actinobacteria. The present study has shown that a strain of Streptomyces griseus, isolated from field sites, elicits pathological changes to the gills ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2008.07.011
更新日期：2009-01-01 00:00:00
abstract：:The whole-body uptake of cadmium by the three-spined stickleback (Gasterosteus aculeatus) has been measured after exposure of fish to 2.5 and 5.0 mg Cd2+/liter hard water and equal amounts of 2.0 mg Cd2+ plus 2 mg Zn2+/liter and 4.0 mg Cd2+ plus 4.0 mg Zn2+/liter hard water, respectively. Fish absorbed and retained ca...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/0147-6513(87)90087-x
更新日期：1987-08-01 00:00:00
abstract：:This study investigated the stress response of earthworms (Eisenia andrei) to exposure to a commonly used herbicide, 2,4 dichloro-phenoxy-acetic acid (2,4-D). We evaluated both stress biomarkers and the transcriptional expression levels and activity of three enzymes involved in oxidative stress responses. Earthworms w...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2015.07.014
更新日期：2015-12-01 00:00:00
abstract：:By testing time-dependent IC50 of luteolin against Microcystis growth, this study revealed 6.5 mg/L as nearly IC50 value during prolonged stress until day 14, and explored chlorophyll-a (CLA) and phycobiliproteins (PBPs) contents, antioxidant responses and microcystin (MC)-production/-release dynamics at rising luteol...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.110540
更新日期：2020-06-15 00:00:00
abstract：:To identify possible cadmium (Cd) accumulators or hyperaccumulators among ornamental plants, a pot experiment involving increasing Cd concentration (0, 5, 15, 30, 60, and 100 mg kg-1) was conducted among seven species. The principal objective was to screen for ornamental plants with an exceptional ability to accumulat...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.06.049
更新日期：2018-10-30 00:00:00
abstract：:Mercury is a unique element that, unlike many metals, has no essential biological function. It is liquid at room temperature and is 13.6 times heavier than water. Its unique physical properties have been exploited for a variety of uses such as in mercury switches, thermostats, thermometers, and other instruments. Its ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章,评审
doi：10.1016/s0147-6513(03)00060-5
更新日期：2003-09-01 00:00:00
abstract：:To maintain the growth and development of pepper in saline condition, candidates of plant growth promoting rhizobacteria (PGPR) were isolated, and detected to plant growth promoting (PGP) potential under salt stress was investigated. Thirteen bacterial strains with 1-aminocyclopropane-1-carboxylate (ACC) deaminase act...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.08.070
更新日期：2018-11-30 00:00:00
abstract：:Effects of 17alpha-ethinylestradiol (EE) on phytoplankton were investigated in a lentic freshwater microcosm study. Treatment with EE caused a shift in the species composition as shown by a principle response curve. Whereas densities of Cyanophyceae, Dinophyceae, and Chrysophyceae increased, those of Conjugatophyceae ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2007.01.014
更新日期：2008-03-01 00:00:00
abstract：:Coal excavation and refinement processes generate substantial volumes of contaminated effluent that may be detrimental to aquatic ecosystems. As such, understanding the impacts of coal mine water releases on aquatic animals and ecosystems is essential for effectively managing and protecting neighboring environments. S...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2016.03.003
更新日期：2016-07-01 00:00:00
abstract：:The selenate removal mechanism of hydrogen-based membrane biofilm reactor (MBfR) for nitrate-polluted groundwater treatment was studied based on anaerobic biofilm analysis. A laboratory-scale MBfR was operated for over 60 days with electron balance, structural analysis, and bacterial community identification. Results ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.04.005
更新日期：2019-08-30 00:00:00
abstract：:Heavy metal contamination of soil resulting from wastewater irrigation is a cause of serious concern due to the potential health impacts of consuming contaminated produce. In this study an assessment is made of the impact of wastewater irrigation on heavy metal contamination of Beta vulgaris (palak); this is a highly ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2005.11.007
更新日期：2007-02-01 00:00:00
abstract：:Studies were made of heavy metal accumulation in aquatic macrophytes growing in streams and ponds around Wroclaw, Poland, partly affected by atmospheric pollution, effluents of chemical factories, and groundwater contaminated by slagdumps from a smelter and power station. The highest concentrations of Cd, Co, Cr, Cu, ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.1996.0106
更新日期：1996-12-01 00:00:00
abstract：:Acute hazard classification based on selected microbiotests was proposed to assess and compare the toxicity of rivers including surface-water, sediment and soil from floodplains. No direct relationship between the classification of pollution for surface-water based on physical-chemical parameters and proposed acute ha...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2008.02.023
更新日期：2008-11-01 00:00:00
abstract：:In recent years, increasing eutrophication in large freshwater lakes, which are an important drinking water source for cities in China, have been resulted in substantial cyanobacteria blooms that could cause serious taste and odor (T&O) problems. In this investigation, three typical lakes (Songhua Lake, Chaohu Lake an...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.06.046
更新日期：2019-10-15 00:00:00
abstract：:The objective of this study was to evaluate the chronic lethal and sublethal aquatic toxicity effects associated with the phytoremediation of water contaminated with 2,4,6-trinitrotoluene (TNT) by the wetland plant species Myriophyllum aquaticum (parrot feather). Rotifers (Brachionus calyciflorus) feeding on an algal ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/s0147-6513(03)00007-1
更新日期：2003-06-01 00:00:00
abstract：:Two experiments were conducted to evaluate the interference of magnesium on zinc adsorption in freshwater fish pond sediment and zinc accumulation in the freshwater teleost Labeo rohita (Hamilton). The study demonstrated that increasing the concentration of magnesium as magnesium sulfate from 100 to 400 mg kg(-1) decr...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2004.03.010
更新日期：2004-10-01 00:00:00
abstract：:The aim of this research was to verify the incidence of endocrine dysfunction associated with mercury intoxication in the hypothalamus-pituitary reproductive system of normally cycling or castrated female rats and the possible protective action of estrogen replacement therapy. We found no differences in the frequency ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2004.12.024
更新日期：2006-03-01 00:00:00
abstract：:The two biological control agents, predatory mite Amblydromalus limonicus Garman & McGregor (Acari: Phytoseiidae) and entomopathogenic fungi (EPF) Beauveria bassiana (Balsamo) Vuillemin (Hypocreales: Cordycipitaceae), have the potential to independently suppress the invasive tomato potato psyllid (TPP), Bactericera co...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.109585
更新日期：2019-11-15 00:00:00
abstract：:The toxicity and environmental risk of chemicals, such as the antiepileptic drug carbamazepine (CBZ), is commonly assessed using standardized laboratory tests and laboratory-to-field extrapolation. To investigate the toxicity of CBZ to aquatic key organisms in a more complex and environmentally relevant scenario, we c...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.109481
更新日期：2019-11-15 00:00:00
abstract：:Carex rigescens is an ornamental turfgrass in northern China which has a relatively low maintenance cost and robust tolerance to many adverse environmental conditions, so it could be considered a new material for researching into plant stress resistance. However, suitable reference genes are vacant for obtaining relia...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.10.049
更新日期：2019-01-30 00:00:00
abstract：:A novel phosphorothionate (2-butenoic acid-3-(diethoxy phosphinothioyl)-methyl ester (RPR-II), synthesized at the Indian Institute of Chemical Technology, Hyderabad, targets its effect on rat brain acetylcholinesterase (AChE) and Na(+)-K(+), Mg(2+), and Ca(2+) ATPases, as evident in this investigation. Three subchroni...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.2000.1956
更新日期：2000-10-01 00:00:00
