Toxic effects of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal on the reproduction of female mice.

Abstract:

:Cigarette smoke can affect female reproductive health by causing follicle destruction and oocyte dysfunction. Third-hand smoke has received increasing attention as a public health issue. However, the effects of third-hand smoke on the female reproductive system, particularly the ovaries, remain unclear. 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA) can be used as a biomarker of third-hand smoke. We studied the in vivo toxic effects of NNA on mice ovaries and offspring development. Three-week-old premature female mice were exposed to NNA at two different concentrations (0.075 μg/kg and 0.15 μg/kg body weight) and tap water (blank control) and diluted dimethylsulfoxide (solvent control) for 30 days. We found that oral administration of NNA (0.075 μg/kg and 0.15 μg/kg) significantly reduced ovary weight (the 0.15 μg/kg group was reduced to 18.69% ± 0.89%) and ovarian follicle number (reduced by about 30%) (p < 0.05). Consumption of 0.15 μg/kg NNA reduced the survival rate of superovulated oocytes from 91.36% to 60.55% (p < 0.05). In addition, treated female mice in each group were mated with normal male mice to observe the effects of NNA on the F1 offspring, and during mating and lactation, all groups were given tap water. Two different concentrations of NNA exposure also significantly reduced body weight and impaired ear opening, tooth eruption and eye opening in F1 offspring, especially those exposed to 0.15 μg/kg NNA (p < 0.05). Our study suggested that NNA exposure had toxic effects on the reproductive health of female mice and their offspring. The results obtained may help evaluate the risks of third-hand smoke to women's reproductive health and to the health of their offspring.

journal_name

Ecotoxicol Environ Saf

authors

Liu H,Liu Z,Meng L,Fu X,Hou Y

doi

10.1016/j.ecoenv.2019.109544

subject

Has Abstract

pub_date

2019-11-15 00:00:00

pages

109544

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(19)30875-9

journal_volume

183

pub_type

杂志文章
  • Growth, yield and quality attributes of a tropical potato variety (Solanum tuberosum L. cv Kufri chandramukhi) under ambient and elevated carbon dioxide and ozone and their interactions.

    abstract::The present study was designed to study the growth and yield responses of a tropical potato variety (Solanum tuberosum L. cv. Kufri chandramukhi) to different levels of carbon dioxide (382 and 570ppm) and ozone (50 and 70ppb) in combinations using open top chambers (OTCs). Plants were exposed to three ozone levels in ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2013.12.021

    authors: Kumari S,Agrawal M

    更新日期:2014-03-01 00:00:00

  • Mechanism and prediction of nonspecific toxicity to fish using bioconcentration characteristics.

    abstract::A basic theory of nonspecific toxicity has been developed using bioconcentration as a basis and applying kinetic relationships developed in previous work. This approach has involved calculation of the critical volume fraction and critical concentration in lipid tissue of fish for a variety of organic compounds at the ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(92)90001-j

    authors: Connell D,Markwell R

    更新日期:1992-12-01 00:00:00

  • Temporal and spatial variations of water quality in the Jinshui River of the South Qinling Mts., China.

    abstract::Water pollution has become a growing threat to human society and natural ecosystems in recent decades, increasing the need to better understand the spatial and temporal variabilities of pollutants within aquatic systems. This study sampled water quality at 12 sampling sites from October 2006 to August 2008 in the Jins...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2009.11.007

    authors: Bu H,Tan X,Li S,Zhang Q

    更新日期:2010-07-01 00:00:00

  • Nanoscale zero-valent iron assisted phytoremediation of Pb in sediment: Impacts on metal accumulation and antioxidative system of Lolium perenne.

    abstract::Lead (Pb) is a highly toxic environmental pollutant, and could result in toxic effects on living organisms. The effects of 0, 100, 200, 500, 1000 and 2000 mg/kg of nZVI on plant growth, Pb accumulation and antioxidative responses of Lolium perenne were investigated. Results showed that the total Pb contents in L. pere...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.01.060

    authors: Huang D,Qin X,Peng Z,Liu Y,Gong X,Zeng G,Huang C,Cheng M,Xue W,Wang X,Hu Z

    更新日期:2018-05-30 00:00:00

  • Effect of chiral differences of metolachlor and its (S)-isomer on their toxicity to earthworms.

    abstract::The effects of (Rac)-metolachlor and (S)-metolachlor on the avoidance behavior, bodyweight change and in vivo enzyme activity of earthworms (Eisenia foetida) were determined and compared in this study. The effects of (Rac)-metolachlor on the enzyme activities of E. foetida and bodyweight were more significant than tho...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2010.07.035

    authors: Xu D,Wen Y,Wang K

    更新日期:2010-11-01 00:00:00

  • Source, spatial distribution, and toxicity potential of Polycyclic Aromatic Hydrocarbons in sediments from Iran's environmentally hot zones, the Persian Gulf.

    abstract::Surface sediments, sampled from Iranian coast of the Persian Gulf (n = 134), were analyzed in order to track spatial distribution of PAHs and their related eco-hazards. The levels of PAHs were in the range of 1.98-814 ng g-1 dw and the region was lowly to moderately polluted. The profile of PAHs was mainly composed of...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.02.029

    authors: Aghadadashi V,Mehdinia A,Riyahi Bakhtiari A,Mohammadi J,Moradi M

    更新日期:2019-05-30 00:00:00

  • Enhanced biogeogenic controls on dichromate speciation in subsoil containment.

    abstract::In general, lab-based Cr (VI) reduction studies do not often corroborate the prevailing biogeochemical controls for on-site pollution abatement. To promulgate its importance, herein, we investigate the existing biogeogenic parameters of a contaminated site to attenuate the underground Cr (VI) toxicity. This study sign...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.110327

    authors: Cj S,T S

    更新日期:2020-04-15 00:00:00

  • Contamination and distribution of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) in agriculture fields in Ya-Er Lake area, China.

    abstract::The contamination and distribution of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) from two agricultural fields of a heavily polluted lake area in China (Ya-Er Lake) are presented. The vertical distribution pattern of total PCDD/Fs in soil cores reveals that the maximum concentration was in the layer ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.2002.2202

    authors: Wu WZ,Schramm KW,Xu Y,Kettrup A

    更新日期:2002-09-01 00:00:00

  • Fermented black barley ameliorates lung injury induced by cooking oil fumes via antioxidant activity and regulation of the intestinal microbiome in mice.

    abstract::To investigate the effect of fermented black barley on cooking oil fume (COF)-induced lung injury, male ICR mice were randomized into five groups: normal control (NC), fermented black barley treatment (NF), COF exposure (O), COF + fermented black barley treatment (OF) and COF + Lactobacillus treatment (OL). The exposu...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.110473

    authors: Ding X,Yang L,Guan Q,Zeng H,Song C,Wu J,Song L

    更新日期:2020-06-01 00:00:00

  • Influence of potassium concentration gradient on stable caesium uptake by Calla palustris.

    abstract::The effect of potassium (K) concentration gradient on stable caesium (Cs) uptake by Calla palustris was studied under hydroponic conditions after eight-day exposure in a greenhouse experiment. The plants were exposed to two different concentrations of Cs (provided as 0.5 and 1 mM CsCl) and five different concentration...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.09.041

    authors: Komínková D,Berchová-Bímová K,Součková L

    更新日期:2018-12-15 00:00:00

  • Characteristics and risk assessments of heavy metals in fine and coarse particles in an industrial area of central China.

    abstract::In order to investigate the pollution level and chemical form transformation characteristics of heavy metals, atmospheric fine particles and coarse particles were collected in an urban industrial area of Zhuzhou City in central China during winter and summer. The results indicated that PM2.5 and PM10 all showed simila...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.04.024

    authors: Zhang X,Zhang K,Lv W,Liu B,Aikawa M,Wang J

    更新日期:2019-09-15 00:00:00

  • Toxic effects of Streptomyces griseus spores and exudate on gill pathology of freshwater fish.

    abstract::Many unexplained fish-kills in British waters are considered microbial in origin and a large proportion of field sites contains elevated concentrations of filamentous actinobacteria. The present study has shown that a strain of Streptomyces griseus, isolated from field sites, elicits pathological changes to the gills ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2008.07.011

    authors: Lewis JW,Morley NJ,Drinkall J,Jamieson BJ,Wright R,Parry JD

    更新日期:2009-01-01 00:00:00

  • PM2.5 induces EMT and promotes CSC properties by activating Notch pathway in vivo and vitro.

    abstract::Fine particulate matter (PM2.5) has been closely linked to increased morbidity and mortality of lung cancer worldwide. However, the role of PM2.5 in the etiology of lung cancer and the mechanism involved in PM2.5 induced lung cancer are largely unknown. In this study, we performed chronic exposure animal model to inve...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.03.086

    authors: Wang Y,Zhong Y,Hou T,Liao J,Zhang C,Sun C,Wang G

    更新日期:2019-08-30 00:00:00

  • Ecotoxicity of arsenic contamination toward the soil enchytraeid Enchytraeus crypticus at different biological levels: Laboratory studies.

    abstract::The ecotoxicity of arsenic (As) contamination toward small soil fauna living in soil pore water such as soil enchytraeids has rarely been studied but is important in the assessment of soil pollution. Here, the endpoints of As ecotoxicity to Enchytraeus crypticus were studied at three biological levels, i.e., individua...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111218

    authors: Li S,Jia M,Li Z,Ke X,Wu L,Christie P

    更新日期:2021-01-01 00:00:00

  • Interactive toxic effects of heavy metals and humic acids on Vibrio fischeri.

    abstract::The effect of humic acids (HAs) on the toxicity of copper, zinc, and lead was investigated using the photobacterium Vibrio fischeri (Microtox test) as a test organism. The effects of HAs on metal toxicity were evaluated as functions of time and concentration in pure compound solutions. The toxicities of copper and lea...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2005.04.005

    authors: Tsiridis V,Petala M,Samaras P,Hadjispyrou S,Sakellaropoulos G,Kungolos A

    更新日期:2006-01-01 00:00:00

  • Effects of plasma proteins on the dehydroabietic acid-induced red cell breakdown.

    abstract::Since red cell hemolysis may play a role in the development of jaundice in fishes exposed to resin acids, we studied the effects of dehydroabietic acid (DHAA) on rainbow trout red cells in vitro. In incubations with physiological saline DHAA caused red cell breakdown at concentrations above 5 mg/liter within 24 hr. In...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(87)90058-3

    authors: Mattsoff L,Nikinmaa M

    更新日期:1987-10-01 00:00:00

  • Ecological risk assessment: risk for what? How do we decide?

    abstract::Ecological risk assessment is defined both in theory and in practice. To do it properly, we need to know what targets we are protecting, but these targets are not always obvious and clearly defined. The pragmatic approach, used most generally in the context of environmental protection legislation, is the risk quotient...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1998.1636

    authors: Calow P

    更新日期:1998-05-01 00:00:00

  • Sediment genotoxicity in the Tietê River (São Paulo, Brazil): in vitro comet assay versus in situ micronucleus assay studies.

    abstract::The in vitro comet assay with the permanent fish cell line RTL-W1 and the in situ micronucleus assay using erythrocytes from indigenous tilapia (Oreochromis niloticus) were used to detect genotoxicity in Tietê River sediments (São Paulo, Brazil). Either test was successful in identifying site-specific differences in g...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2009.04.013

    authors: Rocha PS,Luvizotto GL,Kosmehl T,Böttcher M,Storch V,Braunbeck T,Hollert H

    更新日期:2009-10-01 00:00:00

  • Airway microbiome is associated with respiratory functions and responses to ambient particulate matter exposure.

    abstract:BACKGROUND:Ambient particulate matter (PM) exposure has been associated with respiratory function decline in epidemiological studies. We hypothesize that a possible underlying mechanism is the perturbation of airway microbiome by PM exposure. METHODS:During October 2016-October 2017, on two human cohorts (n = 115 in t...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.09.079

    authors: Wang L,Cheng H,Wang D,Zhao B,Zhang J,Cheng L,Yao P,Di Narzo A,Shen Y,Yu J,Li Y,Xu S,Chen J,Fan L,Lu J,Jiang J,Zhou Y,Wang C,Zhang Z,Hao K

    更新日期:2019-01-15 00:00:00

  • Gas exchange, growth, and chemical parameters in a native Atlantic forest tree species in polluted areas of Cubatão, Brazil.

    abstract::The Atlantic forest species near the industrial complex of Cubatão, Brazil have been subjected to heavy air pollution for decades. In this study, we used some physiological parameters (gas exchange, growth and chemical contents) to biomonitor the effects of air pollution on Tibouchina pulchra, one of the most common t...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/s0147-6513(02)00067-2

    authors: Moraes RM,Delitti WB,Moraes JA

    更新日期:2003-03-01 00:00:00

  • Contamination characteristics, ecological risk and source identification of trace metals in sediments of the Le'an River (China).

    abstract::Recognizing the pollution characteristics of trace metals in river sediments and targeting their potential sources are of key importance for proposing effective strategies to protect watershed ecosystem health. In this study, a comprehensive investigation was conducted to identify the contamination and risk characteri...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2015.11.042

    authors: Chen H,Chen R,Teng Y,Wu J

    更新日期:2016-03-01 00:00:00

  • Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP).

    abstract::Triphenyl phosphate (TPP) has been found in various environmental media and in biota suggesting widespread human exposure. However, there is still insufficient information on the hepatotoxicity mechanisms of health risk exposed to TPP. In this study, TPP could induce human normal liver cell (L02) apoptosis, injury cel...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111126

    authors: Wang X,Li F,Liu J,Ji C,Wu H

    更新日期:2020-12-01 00:00:00

  • Magnetite nanoparticles coated with citric acid are not phytotoxic and stimulate soybean and alfalfa growth.

    abstract::In this work, the internalization and distribution of citric acid-coated magnetite nanoparticles (here, Fe3O4-NPs) in soybean and alfalfa tissues and their effects on plant growth were studied. Both legumes were germinated in pots containing an inert growing matrix (vermiculite) to which Hoagland solution without (con...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2021.111942

    authors: Iannone MF,Groppa MD,Zawoznik MS,Coral DF,Fernández van Raap MB,Benavides MP

    更新日期:2021-01-19 00:00:00

  • Transfer of nodularin to three-spined stickleback (Gasterosteus aculeatus L.), herring (Clupea harengus L.), and salmon (Salmo salar L.) in the northern Baltic Sea.

    abstract::Nodularin (NODLN) is a hepatotoxin produced by the cyanobacterium Nodularia spumigena, which occurs regularly in the Baltic Sea. The primary aim of this study was to study the transfer of NODLN to three-spined stickleback (Gasterosteus aculeatus L.), herring (Clupea harengus membras L.), and salmon (Salmo salar L.), w...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2006.02.006

    authors: Sipiä V,Kankaanpää H,Peltonen H,Vinni M,Meriluoto J

    更新日期:2007-03-01 00:00:00

  • Effects of transgenic corn and Cry1Ab protein on the nematode, Caenorhabditis elegans.

    abstract::The effects of the insecticidal Cry1Ab protein from Bacillus thuringiensis (Bt) on the nematode, Caenorhabditis elegans, were studied with soil from experimental fields cultivated with transgenic Bt corn (MON810) and with trypsinized Cry1Ab protein expressed in Escherichia coli. The content of Cry1Ab protein was above...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2007.10.017

    authors: Höss S,Arndt M,Baumgarte S,Tebbe CC,Nguyen HT,Jehle JA

    更新日期:2008-06-01 00:00:00

  • Acute effect of mercury toxicity on some enzymes in liver of teleost Sarotherodon mossambicus.

    abstract::The effects of 1.5 ppm of mercuric chloride (LC50/48 hr) on some enzymes and organic substances of liver tissue of Sarotherodon mossambicus were studied. Significant decreases in the activities of succinate dehydrogenases, lactate dehydrogenases, glucose-6-phosphate dehydrogenase, alkaline phosphatase, and acid phosph...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(84)90024-1

    authors: Naidu KA,Naidu KA,Ramamurthi R

    更新日期:1984-06-01 00:00:00

  • Three-dimensional porous graphene oxide-maize amylopectin composites with controllable pore-sizes and good adsorption-desorption properties: Facile fabrication and reutilization, and the adsorption mechanism.

    abstract::Three-dimensional (3D) porous graphene oxide-maize amylopectin (GO-MA) composites with controllable pore-sizes composites in the range of 6-40 nm were prepared by facile hydrothermal-assisted assembly approaches. The morphologies, pore sizes, specific surface area (SSA) and compositions of GO-MAx:y composites with and...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.03.069

    authors: Zhao XR,Xu X,Teng J,Zhou N,Zhou Z,Jiang XY,Jiao FP,Yu JG

    更新日期:2019-07-30 00:00:00

  • Defining appropriate methods for studying toxicities of trace metals in nutrient solutions.

    abstract::The use of inappropriate experimental conditions for examining trace metal phytotoxicity results in data of questionable value. The present study aimed to identify suitable parameters for study of phytotoxic metals in nutrient solutions. First, the literature was reviewed to determine the concentration of six metals (...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2017.09.044

    authors: Li Z,Wang P,Menzies NW,Kopittke PM

    更新日期:2018-01-01 00:00:00

  • Differences in cadmium accumulation between indica and japonica rice cultivars in the reproductive stage.

    abstract::Excessive cadmium (Cd) in rice grains is of great concern worldwide, particularly in southern China where heavy metal pollution in the soil is widespread. Much work has been done regarding the key genes responsible for Cd absorption, transport, and accumulation in rice, but little is known about the differences of Cd ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.109795

    authors: Chen H,Yang Y,Ye Y,Tao L,Fu X,Liu B,Wu Y

    更新日期:2019-12-30 00:00:00

  • Effects of methyl mercury on the in vivo release of dopamine and its acidic metabolites DOPAC and HVA from striatum of rats.

    abstract::Mercury is a neurotoxic agent that produces different effects on the brain. In the present work, the effects of chronic doses of methyl mercury (MeHg) were studied on the dopaminergic system of the rat striatum, using microdialysis coupled to high-performance liquid chromatography in order to quantify the in vivo rele...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1997.1567

    authors: Faro LR,Durán R,do Nascimento JL,Alfonso M,Picanço-Diniz CW

    更新日期:1997-11-01 00:00:00