Multiple versus single doses of dexamethasone in total hip arthroplasty: A protocol of randomized controlled trial.

Abstract:

BACKGROUND:Reduction of post-operative pain, nausea, and vomiting in patients undergoing total hip arthroplasty (THA) may facilitate earlier discharge from hospital and reduce healthcare costs. The recommended dose regimen of dexamethasone in THA has not been determined. The purpose of this study was performed to compare the efficiency of multiple versus single doses of dexamethasone for early postoperative pain treatment after THA. METHODS:This study was a randomized controlled trial which conducted in our hospital. Informed consent for participation in this trial was obtained from each patient before surgery. Two hundred patients undergoing THA received 1 dose of intravenous dexamethasone and 1 dose of normal saline (Group A), or 2 doses of intravenous dexamethasone (Group B). The primary outcome was visual analog scale pain scores in the immediate postoperative period. Secondary outcomes included postoperative opioid use, length of hospital stay, activity level during physical therapy, and hip range of motion. RESULTS:This clinical trial might provide some insights to estimate the safety of dexamethasone. TRIAL REGISTRATION:This study protocol was registered in Research Registry (researchregistry5460).

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zhang B,Sun S,Sheng B

doi

10.1097/MD.0000000000020147

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

e20147

issue

19

eissn

0025-7974

issn

1536-5964

pii

00005792-202005080-00077

journal_volume

99

pub_type

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