A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus.

Abstract:

RATIONALE:Lupus erythematosus tumidus (LET) is an uncommon type of cutaneous lupus erythematosus (CLE) that is rarely associated with other forms of lupus erythematosus. PATIENT CONCERNS:We report a 62-year-old Chinese man presented with recurrent erythematous facial plaques for 1 year and a low-grade fever for 1 week. He had been diagnosed as discoid lupus erythematosus (DLE) 1 year before. Physical examination showed diverse lesions, including prominent swelling of the eyelids, a few erythematous, edematous plaques on the left forehead, face, and neck, and 2 hairless macules. The histopathologic findings reveal liquefaction degeneration of the basal cells, perivascular, and periadnexal infiltration of lymphocytes, and interstitial mucin deposition in the superficial, and deep dermis. DIAGNOSES:A diagnosis of LET was made on clinical and histological features. INTERVENTIONS:The patient started treatment with prednisolone (1 mg/kg. d), combined with hydroxychloroquine (200 mg twice daily), and topical tacrolimus. OUTCOMES:The cutaneous lesions completely cleared after a period of 3 months. No adverse effects or clinical evidence of recurrence had been found during the 6-month follow-up period. LESSONS:We report a case of LET converted from DLE with diverse lesions, unusual pathologic findings and slow response to the treatment of corticosteroids combined with hydroxychloroquine. We speculate that a continuous spectrum may include DLE, LET, and systemic lupus erythematosus (SLE), these 3 entities could potentially, convert between each other.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Chen X,Wang S,Li L

doi

10.1097/MD.0000000000010375

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

e0375

issue

16

eissn

0025-7974

issn

1536-5964

pii

00005792-201804200-00016

journal_volume

97

pub_type

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