Abstract:
:The powerful analgesic effects of opioid drugs have captivated the interest of physicians and scientists for millennia, and the ability of opioid drugs to produce serious undesired effects has been recognized for a similar period of time (Kieffer and Evans, 2009). Many of these develop progressively with prolonged or repeated drug use and then persist, motivating particular interest in understanding how opioid drugs initiate adaptive or maladaptive modifications in neural function or regulation. Exciting advances have been made over the past several years in elucidating drug-induced changes at molecular, cellular, and physiologic scales of analysis. The present review will highlight some recent cellular studies that we believe bridge across scales and will focus on optical imaging approaches that put opioid drug action "under the microscope." SIGNIFICANCE STATEMENT: Opioid receptors are major pharmacological targets, but their signaling at the cellular level results from a complex interplay between pharmacology, regulation, subcellular localization, and membrane trafficking. This minireview discusses recent advances in understanding the cellular biology of opioid receptors, emphasizing particular topics discussed at the 50th anniversary of the International Narcotics Research Conference. Our goal is to highlight distinct signaling and regulatory properties emerging from the cellular biology of opioid receptors and discuss potential relevance to therapeutics.
journal_name
Mol Pharmacoljournal_title
Molecular pharmacologyauthors
Jullié D,Gondin AB,von Zastrow M,Canals Mdoi
10.1124/mol.119.119321subject
Has Abstractpub_date
2020-10-01 00:00:00pages
425-432issue
4eissn
0026-895Xissn
1521-0111pii
mol.119.119321journal_volume
98pub_type
杂志文章,评审abstract::In cells expressing both the insulin receptor isoform A (IRA) and the insulin-like growth factor-1 receptor (IGF1R), the presence of hybrid receptors, made up of an alphabeta-IRA chain associated with an alphabeta-IGF1R chain, has been demonstrated. These heterodimers are found in normal cells, and they also seem to p...
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journal_title:Molecular pharmacology
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abstract::The class III antiarrhythmic drugs amiodarone and bretylium tosylate are cationic/amphiphilic, and various substances with these physico-chemical properties are known to directly activate heterotrimeric regulatory G proteins. We asked the question of whether class III antiarrhythmic drugs are also direct G protein act...
journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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更新日期:1988-07-01 00:00:00
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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doi:10.1124/mol.109.058651
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journal_title:Molecular pharmacology
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
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journal_title:Molecular pharmacology
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doi:
更新日期:1993-10-01 00:00:00
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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doi:
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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doi:
更新日期:1998-06-01 00:00:00
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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doi:
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