当前位置： SCI文献检索 > Cell Death & Disease期刊下所有文献 > Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-κB-dependent mechanism.

Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-κB-dependent mechanism.

Abstract：

:Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Here we examined if and how prolyl hydroxylase 2 (PHD2) silencing enhances the paracrine effects of bone-marrow-derived mesenchymal stem cells (BM-MSCs) on NEC. In this study, BM-MSCs were transduced with lentiviruses containing GFP (GFP-MSC) or shPHD2-GFP constructs (PHDMSC), followed by intraperitoneal injection of the PHDMSC-conditioned medium (PHDMSC-CM) or the GFP-MSC-conditioned medium (MSC-CM) into a rat pup model of NEC. Our results showed that systemic infusion of PHDMSC-CM, but not MSC-CM, significantly improved intestinal damage and survival of NEC rats. Such benefits may involve the modulation of epithelial regeneration and inflammation, as indicated by the regeneration of intestinal epithelial/stem cells, the regulation of Treg cells function and pro-/anti-inflammatory cytokine balance. The mechanism for the superior paracrine efficacy of PHDMSC is related to a higher release of pivotal factor IGF-1 and TGF-β2. NF-κB activation was induced by PHD2 silencing to induce IGF-1 and TGF-β2 secretion via binding to IGF-1 and TGF-β2 gene promoter. Our work indicated that PHD2 silencing enhanced the paracrine effect of BM-MSCs on NEC via the NF-κB-dependent mechanism which may be a novel strategy for stem cell therapy on NEC.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Chen H,Zhang H,Zheng Y,Min X,Luo Y,Zhou W,Ma F,Li J,Lu Q,Zhang C,Cai H,Sha W

doi

10.1038/s41419-020-2378-3

subject

Has Abstract

pub_date

2020-03-16 00:00:00

pages

188

issue

3

issn

2041-4889

pii

10.1038/s41419-020-2378-3

journal_volume

11

pub_type

杂志文章

相关文献

Cell Death & Disease文献大全
  • The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

    abstract：:B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We have investigated the structure and function of the least characterized Bcl-2 family member, Bcl-B, solving the crystal structure of a Bcl-B:Bim complex to 1.9 Å resolution. Bcl-B is distinguished from other Bcl-2 family ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2012.178

    authors： Rautureau GJ,Yabal M,Yang H,Huang DC,Kvansakul M,Hinds MG

    更新日期：2012-12-13 00:00:00

  • Azithromycin promotes alternatively activated macrophage phenotype in systematic lupus erythematosus via PI3K/Akt signaling pathway.

    abstract：:Alternatively activated macrophages have been reported to be helpful to alleviate systematic lupus erythematosus (SLE), and azithromycin could serve as an immunomodulator by promoting alternatively activated macrophage phenotype. However, the effect of azithromycin in SLE and the involved mechanism remain undetermined...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1097-5

    authors： Wang J,Xie L,Wang S,Lin J,Liang J,Xu J

    更新日期：2018-10-22 00:00:00

  • FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression.

    abstract：:Cellular senescence is an initial barrier to tumor development that prevents the proliferation of premalignant cells. However, some of the features of senescent cells seem to promote tumor progression via senescence-associated secretory phenotype (SASP). Here, we demonstrated that the protein level of forkhead box Q1 ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.340

    authors： Wang P,Lv C,Zhang T,Liu J,Yang J,Guan F,Hong T

    更新日期：2017-07-20 00:00:00

  • Altering cell death pathways as an approach to cure HIV infection.

    abstract：:Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene therapy, boosting HIV-s...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/cddis.2013.248

    authors： Badley AD,Sainski A,Wightman F,Lewin SR

    更新日期：2013-07-11 00:00:00

  • NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

    abstract：:Cell migration plays pivotal roles in many biological processes; however, its underlying mechanism remains unclear. Here, we find that NudC-like protein 2 (NudCL2), a cochaperone of heat shock protein 90 (Hsp90), modulates cell migration by stabilizing both myosin-9 and lissencephaly protein 1 (LIS1). Either knockdown...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02739-9

    authors： Chen W,Wang W,Sun X,Xie S,Xu X,Liu M,Yang C,Li M,Zhang W,Liu W,Wang L,Zhou T,Yang Y

    更新日期：2020-07-14 00:00:00

  • Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis.

    abstract：:Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an active component extracted from Andrographis paniculate, is prescribed as a treatment for upper respiratory tract infection. Here we rep...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-2195-8

    authors： Gao J,Peng S,Shan X,Deng G,Shen L,Sun J,Jiang C,Yang X,Chang Z,Sun X,Feng F,Kong L,Gu Y,Guo W,Xu Q,Sun Y

    更新日期：2019-12-20 00:00:00

  • MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury.

    abstract：:Murine double minute-2 (MDM2) is an E3-ubiquitin ligase and the main negative regulator of tumor suppressor gene p53. MDM2 has also a non-redundant function as a modulator of NF-kB signaling. As such it promotes proliferation and inflammation. MDM2 is highly expressed in the unchallenged tubular epithelial cells and w...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.390

    authors： Thomasova D,Ebrahim M,Fleckinger K,Li M,Molnar J,Popper B,Liapis H,Kotb AM,Siegerist F,Endlich N,Anders HJ

    更新日期：2016-11-24 00:00:00

  • Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells.

    abstract：:Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02800-7

    authors： Wiese M,Hamdan FH,Kubiak K,Diederichs C,Gielen GH,Nussbaumer G,Carcaboso AM,Hulleman E,Johnsen SA,Kramm CM

    更新日期：2020-08-21 00:00:00

  • H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis.

    abstract：:H. pylori infection is one of the leading causes of gastric cancer and the pathogenicity of H. pylori infection is associated with its ability to induce chronic inflammation and apoptosis resistance. While H. pylori infection-induced expression of pro-inflammatory cytokines for chronic inflammation is well studied, th...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02894-z

    authors： Chen Y,Sheppard D,Dong X,Hu X,Chen M,Chen R,Chakrabarti J,Zavros Y,Peek RM,Chen LF

    更新日期：2020-08-21 00:00:00

  • CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression.

    abstract：:Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90+ and CD90- gbMSCs). However, the different roles in glioma progression have not been exp...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1140-6

    authors： Zhang Q,Yi DY,Xue BZ,Wen WW,Lu YP,Abdelmaksou A,Sun MX,Yuan DT,Zhao HY,Xiong NX,Xiang W,Fu P

    更新日期：2018-10-27 00:00:00

  • Tumor necrosis factor α inhibition overcomes immunosuppressive M2b macrophage-induced bevacizumab resistance in triple-negative breast cancer.

    abstract：:Bevacizumab in neoadjuvant therapy provides a new hope of improved survival for patients with triple-negative breast cancer (TNBC) by targeting vascular endothelial growth factor in combination with chemotherapy, but curative effect is limited by bevacizumab's continuous use while mechanisms remain incompletely unders...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03161-x

    authors： Liu Y,Ji X,Kang N,Zhou J,Liang X,Li J,Han T,Zhao C,Yang T

    更新日期：2020-11-19 00:00:00

  • Metabolism addiction in pancreatic cancer.

    abstract：:Pancreatic ductal adenocarcinoma, an aggressively invasive, treatment-resistant malignancy and the fourth leading cause of cancer deaths in the United States, is usually detectable only when already inevitably fatal. Despite advances in genetic screening, mapping and molecular characterization, its pathology remains l...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/cddis.2014.38

    authors： Blum R,Kloog Y

    更新日期：2014-02-20 00:00:00

  • The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy.

    abstract：:Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors, could interfere with Granzyme B-mediated cell...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1950-1

    authors： Chollat-Namy M,Ben Safta-Saadoun T,Haferssas D,Meurice G,Chouaib S,Thiery J

    更新日期：2019-09-20 00:00:00

  • Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.

    abstract：:Withanolide E, a steroidal lactone from Physalis peruviana, was found to be highly active for sensitizing renal carcinoma cells and a number of other human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Withanolide E, the most potent and least toxic of five TRAIL-se...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.38

    authors： Henrich CJ,Brooks AD,Erickson KL,Thomas CL,Bokesch HR,Tewary P,Thompson CR,Pompei RJ,Gustafson KR,McMahon JB,Sayers TJ

    更新日期：2015-02-26 00:00:00

  • Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion.

    abstract：:The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject of intensive studies...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02864-5

    authors： Hurst S,Gonnot F,Dia M,Crola Da Silva C,Gomez L,Sheu SS

    更新日期：2020-08-19 00:00:00

  • Mitochondria in skin health, aging, and disease.

    abstract：:The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven by a series of protein complexes collectively known as the electron t...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/s41419-020-2649-z

    authors： Sreedhar A,Aguilera-Aguirre L,Singh KK

    更新日期：2020-06-09 00:00:00

  • PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.

    abstract：:Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to dat...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0348-9

    authors： Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q

    更新日期：2018-02-22 00:00:00

  • PIM kinases mediate resistance of glioblastoma cells to TRAIL by a p62/SQSTM1-dependent mechanism.

    abstract：:Glioblastoma (GBM) is the most common and aggressive brain tumor and is associated with poor prognosis. GBM cells are frequently resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and finding new combinatorial therapies to sensitize glioma cells to TRAIL remains an important challenge. PIM ki...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1293-3

    authors： Serrano-Saenz S,Palacios C,Delgado-Bellido D,López-Jiménez L,Garcia-Diaz A,Soto-Serrano Y,Casal JI,Bartolomé RA,Fernández-Luna JL,López-Rivas A,Oliver FJ

    更新日期：2019-01-18 00:00:00

  • Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice.

    abstract：:Immune surveillance through Foxp3+ regulatory T cells plays a crucial role in bone homeostasis. Scurfy, the mouse model of autoimmune IPEX syndrome, bears a loss-of-function mutation in Foxp3 that leads to multi-organ inflammation. Herein, we report that scurfy mice exhibit severe bone loss mediated by accelerated ost...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.87

    authors： Chen TH,Swarnkar G,Mbalaviele G,Abu-Amer Y

    更新日期：2015-04-16 00:00:00

  • PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injury.

    abstract：:Treating corneal endothelial diseases tends to be challenging as human corneal endothelial cells (CECs) do not proliferate in vivo. The pathogenesis or mechanisms underlying injured CECs need further studies. The abnormal expression of PAX6, which is an essential transcription factor for corneal homeostasis, exhibits ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02848-5

    authors： Yu F,Zhang W,Yan C,Yan D,Zhou M,Chen J,Zhao X,Zhu A,Zhou J,Liu H,Sun H,Fu Y

    更新日期：2020-08-12 00:00:00

  • Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.

    abstract：:Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in vivo and its molecular mechanism i...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.114

    authors： Oh SY,Lee SJ,Jung YH,Lee HJ,Han HJ

    更新日期：2015-05-07 00:00:00

  • CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells.

    abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1306-x

    authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

    更新日期：2019-01-25 00:00:00

  • Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC.

    abstract：:As a common female malignancy, triple-negative breast cancer (TNBC) is the most serious subtype in breast cancer (BC). BAALC binder of MAP3K1 and KLF4 (BAALC) is a common oncogene in acute myelocytic leukemia (AML). We sought to explore the role of BAALC in TNBC. In this study, BAALC was significantly upregulated in T...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02821-2

    authors： Li S,Wu D,Jia H,Zhang Z

    更新日期：2020-08-18 00:00:00

  • TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.

    abstract：:Ovarian cancer (OC) is the second leading cause of gynecological cancer death worldwide. Although the list of biomarkers is still growing, molecular mechanisms involved in OC development and progression remain elusive. We recently demonstrated that lower expression of the molecular chaperone TRAP1 in OC patients corre...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.400

    authors： Amoroso MR,Matassa DS,Agliarulo I,Avolio R,Lu H,Sisinni L,Lettini G,Gabra H,Landriscina M,Esposito F

    更新日期：2016-12-15 00:00:00

  • MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.

    abstract：:MicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.297

    authors： Zuo QF,Cao LY,Yu T,Gong L,Wang LN,Zhao YL,Xiao B,Zou QM

    更新日期：2015-11-26 00:00:00

  • Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma.

    abstract：:Tumor-associated macrophages (TAMs) are frequently found near pancreatic cancer cells, but it is uncertain whether they are involved in pancreatic cancer progression and the Warburg effect. Here, we show that CCL18 secreted by TAMs facilitates malignant progression and induced a glycolytic phenotype in pancreatic canc...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0486-0

    authors： Ye H,Zhou Q,Zheng S,Li G,Lin Q,Wei L,Fu Z,Zhang B,Liu Y,Li Z,Chen R

    更新日期：2018-05-01 00:00:00

  • O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas.

    abstract：:Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity of a DNA repair enz...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/cddis.2013.388

    authors： Fan CH,Liu WL,Cao H,Wen C,Chen L,Jiang G

    更新日期：2013-10-24 00:00:00

  • RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4.

    abstract：:Long noncoding RNAs (lncRNAs) have been reported to be involved in a variety of human diseases, including cancers. However, their mechanisms have not yet been fully elucidated. We investigated lncRNA changes that may be associated with pancreatic cancer (PC) by analyzing published microarray data, and identified AGAP2...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1384-9

    authors： Hui B,Ji H,Xu Y,Wang J,Ma Z,Zhang C,Wang K,Zhou Y

    更新日期：2019-02-27 00:00:00

  • 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.

    abstract：:4-hydroxyphenylpyruvate dioxygenase (HPD) is an important modifier of tyrosine metabolism. However, the precise contribution of HPD to cancer metabolism and tumorigenesis remains unclear. In this study, we found that HPD was highly expressed in lung cancer and its higher expression correlated with poor prognosis in lu...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1756-1

    authors： Shan C,Lu Z,Li Z,Sheng H,Fan J,Qi Q,Liu S,Zhang S

    更新日期：2019-07-08 00:00:00

  • MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells.

    abstract：:Mammalian folliculogenesis is a complex process in which primordial follicles develop into pre-ovulatory follicles, followed by ovulation to release mature oocytes. In this study, we explored the role of miR-144 in ovulation. miR-144 was one of the differentially expressed microRNAs, which showed 5.59-fold changes, in...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.24

    authors： Zhou J,Lei B,Li H,Zhu L,Wang L,Tao H,Mei S,Li F

    更新日期：2017-02-09 00:00:00