Identification and validation of key modules and hub genes associated with the pathological stage of oral squamous cell carcinoma by weighted gene co-expression network analysis.

abstract：:Ischemia postconditioning (IPo) is a promising strategy in reducing myocardial ischemia reperfusion (I/R) injury (MIRI), but its specific molecular mechanism is incompletely understood. Langendorff-perfused isolated rat hearts were subjected to global I/R and received IPo in the absence or presence of the mitochondria...

journal_title：PeerJ

authors： Cao S,Liu Y,Wang H,Mao X,Chen J,Liu J,Xia Z,Zhang L,Liu X,Yu T

更新日期：2016-02-16 00:00:00

abstract：:Determining whether a population is introduced or native to a region can be challenging due to inadequate taxonomy, the presence of cryptic lineages, and poor historical documentation. For taxa with resting stages that bloom episodically, determining origin can be especially challenging as an environmentally-triggered...

journal_title：PeerJ

authors： Govindarajan AF,Carman MR,Khaidarov MR,Semenchenko A,Wares JP

更新日期：2017-04-18 00:00:00

abstract：OBJECTIVES:Compare the immediate effects of a Neurodynamic Mobilization (NM) treatment or foam roller (FR) treatment after DOMS. DESIGN:Double blind randomised clinical trial. SETTING:The participants performed 100 drop jumps (5 sets of 20 repetitions, separated by 2 min rests) from a 0.5-m high box in a University b...

journal_title：PeerJ

authors： Romero-Moraleda B,La Touche R,Lerma-Lara S,Ferrer-Peña R,Paredes V,Peinado AB,Muñoz-García D

更新日期：2017-10-13 00:00:00

abstract：Background and Purpose:Several studies have proposed that the advanced lung cancer inflammation index (ALI), a new inflammation-related index, can be used for the prognosis assessment of various malignancies. However, few studies have reported its prognostic value in colorectal cancer (CRC). Therefore, this study explo...

journal_title：PeerJ

authors： Xie H,Huang S,Yuan G,Kuang J,Yan L,Wei L,Tang S,Gan J

更新日期：2020-10-08 00:00:00

abstract：:Beta-diversity, defined as spatial replacement in species composition, is crucial to the understanding of how local communities assemble. These changes can be driven by environmental or geographic factors (such as geographic distance), or a combination of the two. Spiders have been shown to be good indicators of envir...

journal_title：PeerJ

authors： Rodriguez-Artigas SM,Ballester R,Corronca JA

更新日期：2016-04-21 00:00:00

abstract：:Abnormalities in mitochondrial function have previously been shown in chronic fatigue syndrome (CFS) patients, implying that mitochondrial dysfunction may contribute to the pathogenesis of disease. This study builds on previous work showing that mitochondrial respiratory parameters are impaired in whole cells from CFS...

journal_title：PeerJ

authors： Tomas C,Brown AE,Newton JL,Elson JL

更新日期：2019-03-01 00:00:00

abstract：:There is a lack of stability in language difficulties across early childhood: most late talkers (LTs) resolve their difficulties by pre-school; and a significant number of children who were not LTs subsequently manifest language difficulties. Greater reliability in predicting individual outcomes is needed, which might...

journal_title：PeerJ

authors： Duff FJ,Nation K,Plunkett K,Bishop D

更新日期：2015-07-23 00:00:00

abstract：:Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment of diuresis, bacterial infections and cancer, as well as a...

journal_title：PeerJ

authors： Zhou L,Fu X,Jiang L,Wang L,Bai S,Jiao Y,Xing S,Li W,Ma J

更新日期：2017-12-20 00:00:00

abstract：:Background. Physical activity is important for children's physical, mental, and social well-being. Outdoor active play is an important yet unstudied domain of children's physical activity. The objective of this study was to determine if parental encouragement is associated with the frequency that children engage in ou...

journal_title：PeerJ

authors： Ferrao T,Janssen I

更新日期：2015-11-30 00:00:00

abstract：Background:The coral genus Acropora contains more than 150 species with very high morphological diversity. This high diversity may have been caused by repeated hybridization via mass spawning. However, we have little information whether hybrids are formed in these corals. Identifying morphological differences between h...

journal_title：PeerJ

authors： Fukami H,Iwao K,Kumagai NH,Morita M,Isomura N

更新日期：2019-02-19 00:00:00

abstract：:Diarrhea is a syndrome of digestive disorders in young rabbits and may lead to secondary infections resulting in reduced immunity and higher mortality in baby rabbits, with serious impacts on rabbit farming. In this study, we investigated the effects of diarrhea on the health of baby rabbits in terms of intestinal muc...

journal_title：PeerJ

authors： Chen Y,Zhao B,Wu Y,Hu S,Mu L,Zhu C,Pan Y,Wu X

更新日期：2017-11-27 00:00:00

abstract：Aim:We aimed to translate and cross-culturally adapt the International Knee Documentation Committee-subjective knee form (IKDC) in Romanian. Method:The original (US) IKDC-subjective knee form was translated according to recommended guidelines. Validity was tested using Spearmans's correlation coefficient between score...

journal_title：PeerJ

authors： Todor A,Vermesan D,Haragus H,Patrascu JM Jr,Timar B,Cosma DI

更新日期：2020-02-03 00:00:00

abstract：:N6-methyladenosine (m6A) modifications can be found in eukaryotic messenger RNA (mRNA), long non-coding RNA (lncRNA), and microRNA (miRNA). Several studies have demonstrated a close relationship between m6A modifications and cancer cells. Methyltransferase-like enzyme 3 (METTL3) and methyltransferase-like enzyme 14 (M...

journal_title：PeerJ

authors： Tao Z,Zhao Y,Chen X

更新日期：2020-07-22 00:00:00

abstract：Background:Mimusops coriacea (A.DC.) Miq., (Sapotaceae), originated from Africa, were introduced to coastal areas in Ecuador where it is not extensively used as a traditional medicine to treat various human diseases. Different therapeutically uses of the species include: analgesic, antimicrobial, hypoglycemic, inflamma...

journal_title：PeerJ

authors： Bustamante K,Santos-Ordóñez E,Miranda M,Pacheco R,Gutiérrez Y,Scull R

更新日期：2019-10-11 00:00:00

abstract：:Objectives. Diabetes mellitus (DM) and hypothyroidism are each associated with increased rate of pregnancy complications. However, their combined morbidity during gestation is poorly studied. Therefore, the aims of this study were to determine the prevalence of the combined morbidity of DM & hypothyroidism and whether...

journal_title：PeerJ

authors： Tirosh D,Benshalom-Tirosh N,Novack L,Press F,Beer-Weisel R,Wiznitzer A,Mazor M,Erez O

更新日期：2013-03-19 00:00:00

abstract：:Wildlife demography is typically studied at a single point in time within a year when species, often during the reproductive season, are more active and therefore easier to find. However, this provides only a low-resolution glimpse into demographic temporal patterns over time and may hamper a more complete understandi...

journal_title：PeerJ

authors： Guimarães M,Correa DT,Gaiarsa MP,Kéry M

更新日期：2020-02-25 00:00:00

abstract：:Humans were once considered unique in having a concept of death but a growing number of observations of animal responses to dying and dead conspecifics suggests otherwise. Complex arrays of behaviors have been described ranging from corpse removal and burial among social insects to quiet attendance and caregiving amon...

journal_title：PeerJ

authors： Porter A,Eckardt W,Vecellio V,Guschanski K,Niehoff PP,Ngobobo-As-Ibungu U,Nishuli Pekeyake R,Stoinski T,Caillaud D

更新日期：2019-04-02 00:00:00

abstract：Purpose:Recent studies have determined that long non-coding RNAs (lncRNAs) are potential prognostic biomarkers for non-small cell lung cancers (NSCLCs). The purpose of this study was to analyze the function and associated pathways of zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) in NSCLC cells. Methods:W...

journal_title：PeerJ

authors： Wang X,Tang J,Zhao J,Lou B,Li L

更新日期：2020-10-26 00:00:00

abstract：Background:Dinoflagellates have the potential to pose severe ecological and economic damages to aquatic ecosystems. It is therefore largely needed to understand the causes and consequences of distribution patterns of dinoflagellate communities in order to manage potential environmental problems. However, a majority of ...

journal_title：PeerJ

authors： Gao Y,Chen Y,Xiong W,Li S,Zhan A

更新日期：2019-04-09 00:00:00

abstract：:The use of baited remote underwater video (BRUV) for examining and monitoring marine biodiversity in temperate marine environments is rapidly growing, however many aspects of their effectiveness relies on assumptions based on studies from the Southern Hemisphere. The addition of bait to underwater camera systems acts ...

journal_title：PeerJ

authors： Jones RE,Griffin RA,Januchowski-Hartley SR,Unsworth RKF

更新日期：2020-08-27 00:00:00

abstract：Purpose:Most studies on neuroblastoma (NB) have been conducted in Western countries or Japan. The objective of our study was to analyze clinical and pathological features, MYCN status, surgical methods, and prognosis in Chinese NB patients. Methods:A retrospective, single-center case series study of 275 NBs was implem...

journal_title：PeerJ

authors： Ma Y,Zheng J,Feng J,Chen L,Dong K,Xiao X

更新日期：2018-09-17 00:00:00

abstract：:Since 2014, Stony Coral Tissue Loss Disease (SCTLD) has led to mass mortality of the majority of hard coral species on the Florida Reef Tract. Following the successful treatment of SCTLD lesions on laboratory corals using water dosed with antibiotics, two topical pastes were developed as vehicles to directly apply ant...

journal_title：PeerJ

authors： Neely KL,Macaulay KA,Hower EK,Dobler MA

更新日期：2020-06-09 00:00:00

abstract：Background:Plant reproduction is influenced by the net outcome of plant-herbivore and plant-pollinator interactions. While both herbivore impacts and pollinator impacts on plant reproduction have been widely studied, few studies examine them in concert. Methodology:Here, we review the contemporary literature that exam...

journal_title：PeerJ

authors： Haas SM,Lortie CJ

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Profiling of microbial communities via metagenomic shotgun sequencing has enabled researches to gain unprecedented insight into microbial community structure and the functional roles of community members. This study describes a method and basic analysis for a metagenomic adaptation of the double digest restr...

journal_title：PeerJ

authors： Liu MY,Worden P,Monahan LG,DeMaere MZ,Burke CM,Djordjevic SP,Charles IG,Darling AE

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock 1 peptides that replicate the functional biophysics of ...

journal_title：PeerJ

authors： Notter RH,Gupta R,Schwan AL,Wang Z,Shkoor MG,Walther FJ

更新日期：2016-10-27 00:00:00

abstract：Background:Alzheimer's disease (AD) is a prevalent progressive neurodegenerative human disease whose cause remains unclear. Numerous initially highly hopeful anti-AD drugs based on the amyloid-β (Aβ) hypothesis of AD have failed recent late-phase tests. Natural aging (AG) is a high-risk factor for AD. Here, we aim to g...

journal_title：PeerJ

authors： Peng YS,Tang CW,Peng YY,Chang H,Chen CL,Guo SL,Wu LC,Huang MC,Lee HC

更新日期：2020-03-20 00:00:00

abstract：:Background. The relative efficacy and safety of lacosamide as adjunctive therapy compared to other antiepileptic drugs has not been well established. Objective. To determine if lacosamide provides improved efficacy and safety, reduced length of hospital stay and improved quality of life compared with other anti-epilep...

journal_title：PeerJ

authors： Sawh SC,Newman JJ,Deshpande S,Jones PM

更新日期：2013-08-06 00:00:00

abstract：Aims:The study aimed to explore factors contributing to body weight change over time in gastric cancer patients after gastrectomy, in order to find risk factors to implement nutritional intervention beforehand. Methods:A cohort of gastric cancer patients who were treated with gastrectomy from January to March 2019 at ...

journal_title：PeerJ

authors： Tian Q,Qin L,Zhu W,Xiong S,Wu B

更新日期：2020-07-10 00:00:00

abstract：:This article aimed to give the visibility of Latin American researchers' contributions to the comprehension of COVID-19; our method was a literature review. Currently, the world is facing a health and socioeconomic crisis caused by the novel coronavirus, SARS-CoV-2, and its disease COVID-19. Therefore, in less than 4 ...

journal_title：PeerJ

authors： Fiesco-Sepúlveda KY,Serrano-Bermúdez LM

更新日期：2020-06-04 00:00:00

abstract：:Esophageal cancer is a common malignant tumor in the world, and the aim of this study was to screen key genes related to the development of esophageal cancer using a variety of bioinformatics analysis tools and analyze their biological functions. The data of esophageal squamous cell carcinoma from the Gene Expression ...

journal_title：PeerJ

authors： Guan X,Yao Y,Bao G,Wang Y,Zhang A,Zhong X

更新日期：2020-03-31 00:00:00