Fibronectin observed in the nuclear matrix of HeLa tumour cells.

abstract：:Maturation of nociceptive neurons depends on changes in transcription factors, ion channels and neuropeptides. Mature nociceptors initiate pain in part by drastically reducing the activation threshold via intracellular sensitization signaling. Whether sensitization signaling also changes during development and aging r...

journal_title：Journal of cell science

authors： Isensee J,Schild C,Schwede F,Hucho T

更新日期：2017-07-01 00:00:00

abstract：:Assembly of the nuclear envelope (NE) in telophase is essential for higher eukaryotic cells to re-establish a functional nucleus. Time-lapse, FRAP and FRET analyses in human cells showed that barrier-to-autointegration factor (BAF), a DNA-binding protein, assembled first at the distinct ;core' region of the telophase ...

journal_title：Journal of cell science

authors： Haraguchi T,Kojidani T,Koujin T,Shimi T,Osakada H,Mori C,Yamamoto A,Hiraoka Y

更新日期：2008-08-01 00:00:00

abstract：:During cytokinesis, the central spindle, a bundle of interdigitated anti-parallel microtubules between separating chromosomes, recruits various cytokinetic regulator proteins to the cleavage region. Here, we show that the level of protein ubiquitylation is strikingly and transiently elevated in Aurora B kinase-positiv...

journal_title：Journal of cell science

authors： Mukai A,Mizuno E,Kobayashi K,Matsumoto M,Nakayama KI,Kitamura N,Komada M

更新日期：2008-04-15 00:00:00

abstract：:Cell migration is required during development of the nervous system. The regulatory mechanisms for this process, however, are poorly elucidated. We show here that expression of or exposure to the neural cell adhesion molecule (NCAM) strongly affected the motile behaviour of glioma cells independently of homophilic NCA...

journal_title：Journal of cell science

authors： Prag S,Lepekhin EA,Kolkova K,Hartmann-Petersen R,Kawa A,Walmod PS,Belman V,Gallagher HC,Berezin V,Bock E,Pedersen N

更新日期：2002-01-15 00:00:00

abstract：:ARF-like proteins (ARLs) are distinct group of members of the ARF family of Ras-related GTPases. Although ARLs are very similar in primary structure to ARFs, their functions remain unclear. We cloned mouse (m) and human (h) ARL5 cDNAs to characterize the protein products and their molecular properties. mARL5 mRNA was ...

journal_title：Journal of cell science

authors： Lin CY,Li CC,Huang PH,Lee FJ

更新日期：2002-12-01 00:00:00

abstract：:The specification of organs, tissues and cell types results from cell fate restrictions enacted by nuclear transcription factors under the control of conserved signaling pathways. The progenitor epithelium of the Drosophila compound eye, the eye imaginal disc, is a premier model for the study of such processes. Early ...

journal_title：Journal of cell science

authors： Neal SJ,Zhou Q,Pignoni F

更新日期：2020-05-26 00:00:00

abstract：:During the first meiotic prophase, alignment and synapsis of the homologous chromosomes are mediated by the synaptonemal complex. Incorrect assembly of this complex results in cell death, impaired meiotic recombination and formation of aneuploid germ cells. We have identified a novel mouse meiosis-specific protein, TE...

journal_title：Journal of cell science

authors： Hamer G,Gell K,Kouznetsova A,Novak I,Benavente R,Höög C

更新日期：2006-10-01 00:00:00

abstract：:We have identified and characterized two proteins in rat brain that bind to the neuron-specific tropomyosin isoform, TMBr3. The two proteins were identified by blot overlay assay, in which the proteins immobilized on the membrane were probed by epitope-tagged TMBr3, followed by detection with anti-epitope antibody. We...

journal_title：Journal of cell science

authors： Watakabe A,Kobayashi R,Helfman DM

更新日期：1996-09-01 00:00:00

abstract：:Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role in various cellular pathways, including but not limited to protein trafficking, subcellular localization, innate immune response, viral infections, DNA damage responses and apoptosis. To date, 28 HECT E3 ubiquitin ligases have been identifi...

journal_title：Journal of cell science

authors： Wang Y,Argiles-Castillo D,Kane EI,Zhou A,Spratt DE

更新日期：2020-04-07 00:00:00

abstract：:The SPN antigen plays an essential role in mitosis, since microinjection of antibodies causes mitotic arrest. Here we show, by examination of the relative locations of SPN antigen, the centrosomal 5051 antigen and tubulin in normal mitotic, and in taxol-treated mitotic cells, that the SPN antigen is involved in organi...

journal_title：Journal of cell science

authors： Kallajoki M,Weber K,Osborn M

更新日期：1992-05-01 00:00:00

abstract：:Although epithelial-mesenchymal (stromal) interactions are thought to play an important role in embryonic and postnatal development of the mammary gland, the underlying mechanisms are still poorly understood. To address this issue, we assessed the effect of fibroblast-derived diffusible factors on the growth and morph...

journal_title：Journal of cell science

authors： Soriano JV,Pepper MS,Nakamura T,Orci L,Montesano R

更新日期：1995-02-01 00:00:00

abstract：:Crumbs (Crb) is an evolutionarily conserved transmembrane protein localised to the apical membrane of epithelial cells. Loss or mislocalisation of Crb is often associated with disruption of apicobasal cell polarity. crb mRNA is also apically enriched in epithelial cells, and, as shown here, accumulates in the oocyte o...

journal_title：Journal of cell science

authors： Bhagavatula S,Knust E

更新日期：2021-01-25 00:00:00

abstract：:The water pipes of elongating plant organs are the result of programmed cell death and are formed by the walls of dead and empty protoxylem elements. These protoxylem elements are passively elongated many times by the surrounding tissue before they are replaced and collapse. Well-known adaptations for this unique task...

journal_title：Journal of cell science

authors： Ryser U,Schorderet M,Guyot R,Keller B

更新日期：2004-03-01 00:00:00

abstract：:During meiotic prophase in the ciliate Tetrahymena thermophila micronuclei dramatically elongate and form thread-like crescents. The arrangement of the chromosomes within the crescent as well as the timing of chromosome pairing and recombination with respect to the elongation process have been subjects of ongoing deba...

journal_title：Journal of cell science

authors： Loidl J,Scherthan H

更新日期：2004-11-15 00:00:00

abstract：:We previously reported that integrin alpha 3 beta 1 mediates epidermal intercellular adhesion as well as cell-substrate adhesion. P1B5, an anti-alpha 3 beta 1 specific monoclonal antibody, is a potent in vitro trigger of epidermal cell-cell adhesion and an inhibitor of cell-substrate adhesion. We now show that P1B5 sp...

journal_title：Journal of cell science

authors： Symington BE,Carter WG

更新日期：1995-02-01 00:00:00

abstract：:The sclerotome portion of the differentiating embryonic chick somite becomes infiltrated by neural crest cells prior to its dispersal towards the embryonic axis. This means that sclerotome cells explanted into culture for the purpose of examining their interactions in vitro are contaminated with a proportion of neural...

journal_title：Journal of cell science

authors： Sanders EJ,Cheung E

更新日期：1988-05-01 00:00:00

abstract：:Iron (Fe(2+), Fe(3+)) homeostasis is a tightly regulated process, involving precise control of iron influx and egress from cells. Although the mechanisms of its import into cells by iron carrier molecules are well characterized, iron export remains poorly understood. The current paradigm envisages unique functions ass...

journal_title：Journal of cell science

authors： Sheokand N,Malhotra H,Kumar S,Tillu VA,Chauhan AS,Raje CI,Raje M

更新日期：2014-10-01 00:00:00

abstract：:Neural progenitors in the vertebrate nervous system are fully polarized epithelial cells, with intercellular junctions at the apical region. These progenitor cells remain within the neuroepithelium throughout neurogenesis, and will ultimately give rise to all the neurons in the mature nervous system. We have addressed...

journal_title：Journal of cell science

authors： Afonso C,Henrique D

更新日期：2006-10-15 00:00:00

abstract：:In hepatocytes, PLIN2 is the major protein coating lipid droplets (LDs), an organelle the hepatitis C virus (HCV) hijacks for virion morphogenesis. We investigated the consequences of PLIN2 deficiency on LDs and on HCV infection. Knockdown of PLIN2 did not affect LD homeostasis, likely due to compensation by PLIN3, bu...

journal_title：Journal of cell science

authors： Lassen S,Grüttner C,Nguyen-Dinh V,Herker E

更新日期：2019-01-09 00:00:00

abstract：:The cell surface delivery of extracellular matrix (ECM) and integrins is fundamental for cell migration in wound healing and during cancer cell metastasis. This process is not only driven by several soluble NSF attachment protein (SNAP) receptor (SNARE) proteins, which are key players in vesicle transport at the cell ...

journal_title：Journal of cell science

authors： Enrich C,Rentero C,Hierro A,Grewal T

更新日期：2015-03-15 00:00:00

abstract：:Notch signaling is pivotal for the morphogenesis and homeostasis of many tissues. We found that aberrant Notch activation in mouse neural-crest-derived periocular mesenchymal cells (POMCs), which contribute to the formation of corneal and eyelid stroma, results in blepharophimosis. Compound transgenic mice overexpress...

journal_title：Journal of cell science

authors： Zhang Y,Kao WW,Pelosi E,Schlessinger D,Liu CY

更新日期：2011-08-01 00:00:00

abstract：:How cell fate becomes restricted during somatic cell differentiation is a long-lasting question in biology. Epigenetic mechanisms not present in pluripotent cells and acquired during embryonic development are expected to stabilize the differentiated state of somatic cells and thereby restrict their ability to convert ...

journal_title：Journal of cell science

authors： Pasque V,Radzisheuskaya A,Gillich A,Halley-Stott RP,Panamarova M,Zernicka-Goetz M,Surani MA,Silva JC

更新日期：2012-12-15 00:00:00

abstract：:The protozoan parasite Giardia lamblia has the unusual morphology of bearing two equal-sized nuclei. This organism probably represents the earliest diverging lineage of eukaryotes, suggesting that its biological tactics may be transitional. To begin to understand the role played by the two equal-sized nuclei in this o...

journal_title：Journal of cell science

authors： Kabnick KS,Peattie DA

更新日期：1990-03-01 00:00:00

abstract：:The process of angiogenesis requires endothelial cells (ECs) to undergo profound changes in shape and polarity. Although this must involve remodelling of the EC cytoskeleton, little is known about this process or the proteins that control it. We used a co-culture assay of angiogenesis to examine the cytoskeleton of EC...

journal_title：Journal of cell science

authors： Hetheridge C,Scott AN,Swain RK,Copeland JW,Higgs HN,Bicknell R,Mellor H

更新日期：2012-03-15 00:00:00

abstract：:High-throughput neurotransmission at ribbon synapses of cochlear inner hair cells (IHCs) requires tight coupling of neurotransmitter release and balanced recycling of synaptic vesicles (SVs) as well as rapid restoration of release sites. Here, we examined the role of the adaptor protein AP180 (also known as SNAP91) fo...

journal_title：Journal of cell science

authors： Kroll J,Özçete ÖD,Jung S,Maritzen T,Milosevic I,Wichmann C,Moser T

更新日期：2020-01-22 00:00:00

abstract：:Inhibitory and excitatory neurons exhibit distinct patterns of development in the mammalian cerebral cortex. The morphological development of inhibitory and excitatory neurons derived from fetal rat cerebral cortex has now been compared in vitro. Inhibitory neurons were identified by immunofluorescence staining with a...

journal_title：Journal of cell science

authors： Hayashi K,Kawai-Hirai R,Harada A,Takata K

更新日期：2003-11-01 00:00:00

abstract：:The binding of GFP-tagged tetracycline repressor (TetR) molecules to chromosomally integrated tetracycline operator (tetO) sequence repeats has been used as a system to study chromosome behaviour microscopically in vivo. We found that these integrated transgenes influence the architecture of yeast interphase nuclei, a...

journal_title：Journal of cell science

authors： Fuchs J,Lorenz A,Loidl J

更新日期：2002-03-15 00:00:00

abstract：:Here, we identify a role for the matrilin-2 (Matn2) extracellular matrix protein in controlling the early stages of myogenic differentiation. We observed Matn2 deposition around proliferating, differentiating and fusing myoblasts in culture and during muscle regeneration in vivo. Silencing of Matn2 delayed the express...

journal_title：Journal of cell science

authors： Deák F,Mátés L,Korpos E,Zvara A,Szénási T,Kiricsi M,Mendler L,Keller-Pintér A,Ozsvári B,Juhász H,Sorokin L,Dux L,Mermod N,Puskás LG,Kiss I

更新日期：2014-08-01 00:00:00

abstract：:Junction dynamics of endothelial cells are based on the integration of signal transduction, cytoskeletal remodeling and contraction, which are necessary for the formation and maintenance of monolayer integrity, but also enable repair and regeneration. The VE-cadherin-catenin complex forms the molecular basis of the ad...

journal_title：Journal of cell science

authors： Cao J,Schnittler H

更新日期：2019-01-03 00:00:00

abstract：:During mitosis, the cell sequentially constructs two microtubule-based spindles to ensure faithful segregation of chromosomes. A bipolar spindle first pulls apart the sister chromatids, then a central spindle further separates them away. Although the assembly of the first spindle is well described, the assembly of the...

journal_title：Journal of cell science

authors： Courthéoux T,Reboutier D,Vazeille T,Cremet JY,Benaud C,Vernos I,Prigent C

更新日期：2019-05-16 00:00:00