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The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.

Abstract：

:Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH is a serious condition that can progress to cirrhosis, liver failure, and hepatocellular carcinoma. The association of NASH with obesity, type 2 diabetes mellitus, and dyslipidemia has led to an emerging picture of NASH as the liver manifestation of metabolic syndrome. Although diet and exercise can dramatically improve NASH outcomes, significant lifestyle changes can be challenging to sustain. Pharmaceutical therapies could be an important addition to care, but currently none are approved for NASH. Here, we review the most promising targets for NASH treatment, along with the most advanced therapeutics in development. These include targets involved in metabolism (e.g., sugar, lipid, and cholesterol metabolism), inflammation, and fibrosis. Ultimately, combination therapies addressing multiple aspects of NASH pathogenesis are expected to provide benefit for patients.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Romero FA,Jones CT,Xu Y,Fenaux M,Halcomb RL

doi

10.1021/acs.jmedchem.9b01701

subject

Has Abstract

pub_date

2020-05-28 00:00:00

pages

5031-5073

issue

10

eissn

0022-2623

issn

1520-4804

journal_volume

63

pub_type

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