Combating Donor Organ Shortage: Organ Care System Prolonging Organ Storage Time and Improving the Outcome of Heart Transplantations.

abstract：AIM:Cardiac hypertrophy and myocardial fibrosis significantly contribute to the pathogenesis of diabetic cardiomyopathy (DCM). Altered expression of several genes and their regulation by microRNAs has been reported in hypertrophied failing hearts. This study aims to examine the role of Cdc42, Pak1, and miR-30c in the p...

journal_title：Cardiovascular therapeutics

authors： Raut SK,Kumar A,Singh GB,Nahar U,Sharma V,Mittal A,Sharma R,Khullar M

更新日期：2015-06-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a common and independent risk factor for cardiovascular events in patients with coronary artery disease (CAD). Controlling blood pressure is the standard approach to the management of LVH, but this is only partially effective as LVH also persists in normotensive patients. Apart fr...

journal_title：Cardiovascular therapeutics

authors： Mohan M,McSwiggan S,Baig F,Rutherford L,Lang CC

更新日期：2015-02-01 00:00:00

abstract：:Patients with peripheral artery disease (PAD) and critical limb ischemia are the main candidates for limb amputations and have a poor life expectancy. Frequently, these patients are not eligible for either surgical or percutaneous interventions aimed at mechanical revascularization. Therefore, new strategies need to b...

journal_title：Cardiovascular therapeutics

authors： Germani A,Di Campli C,Pompilio G,Biglioli P,Capogrossi MC

更新日期：2009-01-01 00:00:00

abstract：:Thiazide diuretics are one of the most widely used and cost-effective classes of antihypertensive agents worldwide. Thiazides however have a significant side effect profile and are frequently insufficient to normalize blood pressure alone. Thiazide-induced hyponatraemia (TIH) is a major adverse effect, affecting up to...

journal_title：Cardiovascular therapeutics

authors： Glover M,Clayton J

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Vitamin K antagonists, such as warfarin, are known to promote arterial calcification through blockade of gamma-carboxylation of Matrix-Gla-Protein. It is currently unknown whether other oral anticoagulants such as direct inhibitors of Factor Xa can have protective effects on the progression of aortic valve...

journal_title：Cardiovascular therapeutics

authors： Rattazzi M,Faggin E,Bertacco E,Nardin C,Pagliani L,Plebani M,Cinetto F,Guidolin D,Puato M,Pauletto P

更新日期：2018-08-01 00:00:00

abstract：:Atrial fibrillation (AF) has been defined as the new cardiovascular "epidemic". Its prevalence is rising in developed countries, and the associated social and economic costs are high. In the last few years, there has been an increasing interest in understanding the mechanisms of AF and its management. New pharmacother...

journal_title：Cardiovascular therapeutics

authors： Romero I,Nedios S,Kriatselis C

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage (ICH) is the most fearful side effect of oral anticoagulant therapy. It is still unclear which risk factor is involved in ICH during vitamin K antagonists (VKAs) treatment and if commonly used bleeding risk scores are able to predict ICH. PURPOSE:Search for individual risk factors an...

journal_title：Cardiovascular therapeutics

authors： Zanella L,Zoppellaro G,Marigo L,Denas G,Padayattil Jose S,Pengo V

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The systematic review and meta-analysis are to evaluate the effect of t Telmisartan on atrial fibrillation (AF) recurrences in hypertensive patients with paroxysmal AF. METHODS:MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. Random controlled trials (RCTs) were conduct...

journal_title：Cardiovascular therapeutics

authors： Pan G,Zhou X,Zhao J

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that intensive lipid lowering using rosuvastatin results in regression of coronary plaques. However, few data exist regarding lipid profiles over time, drug tolerability, and the effects of prior use of lipid lowering agents in patients on rosuvastatin treatment. Therefore,...

journal_title：Cardiovascular therapeutics

authors： Kawashiri MA,Yamagishi M,Sakamoto T,Takayama T,Hiro T,Daida H,Hirayama A,Saito S,Yamaguchi T,Matsuzaki M,COSMOS Investigators.

更新日期：2013-12-01 00:00:00

abstract：:Atrial fibrillation (AF) is very common within the first 5 days of cardiac surgery. It is associated with significant morbidity including stroke, ventricular arrhythmias, myocardial infarction, heart failure, acute kidney injury, prolonged hospital stay, and also short- and long-term mortality. The underlying mechanis...

journal_title：Cardiovascular therapeutics

authors： Ho KM,Lewis JP

更新日期：2010-04-01 00:00:00

abstract：:Accelerated atherosclerosis and microvascular complications are the leading causes of coronary heart disease, stroke, blindness, and end-stage renal failure, which could account for disabilities and high mortality rates in patients with diabetes. Recent clinical studies have substantiated the concept of "hyperglycemic...

journal_title：Cardiovascular therapeutics

authors： Yamagishi S,Nakamura K,Matsui T,Ueda S,Noda Y,Imaizumi T

更新日期：2008-04-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance found in clinical practice, increasing in prevalence with age. AF is often associated with structural heart disease, although a significant proportion has no detectable heart disease. In the last 2 decades, there has been an increase of 6...

journal_title：Cardiovascular therapeutics

authors： Escobar C,Barrios V,Jimenez D

更新日期：2010-10-01 00:00:00

abstract：:Sex-specific differences have been definitively demonstrated in cardiovascular (CV) diseases. These differences can also impact on the effects of CV therapies. Female sex is recognized as an independent predictor of thromboembolic risk, particularly in older patients. Most of strokes are due to atrial fibrillation (AF...

journal_title：Cardiovascular therapeutics

authors： Gallù M,Marrone G,Legramante JM,De Lorenzo A,Di Daniele N,Noce A

更新日期：2020-06-18 00:00:00

abstract：:Morbidity of patients with cardiac syndrome X (typical anginal-like chest pain and normal coronary arteriogram) is high with continuing episodes of chest pain and frequent hospital readmissions. Management of this syndrome represents a major challenge for the treating physician. Conventional therapies with antianginal...

journal_title：Cardiovascular therapeutics

authors： Lim TK,Choy AJ,Khan F,Belch JJ,Struthers AD,Lang CC

更新日期：2009-04-01 00:00:00

abstract：:Prediabetes is an intermediate hyperglycaemic state which has been associated with cardiovascular dysfunction. However, cardiovascular dysfunction is not only caused by intermediate hyperglycaemia but also endothelial dysfunction, inflammation, and oxidative stress associated with prediabetes. Bredemolic acid (BA), an...

journal_title：Cardiovascular therapeutics

authors： Akinnuga AM,Siboto A,Khumalo B,Sibiya NH,Ngubane P,Khathi A

更新日期：2020-02-11 00:00:00

abstract：:The mitochondrial F1F0 ATP synthase is responsible for the majority of ATP production in mammals and does this through a rotary catalytic mechanism. Studies show that the F1F0 ATP synthase can switch to an ATP hydrolase, and this occurs under conditions seen during myocardial ischemia. This ATP hydrolysis causes wasti...

journal_title：Cardiovascular therapeutics

authors： Grover GJ,Malm J

更新日期：2008-01-01 00:00:00

abstract：:Spirulina is free-floating filamentous microalgae growing in alkaline water bodies. With its high nutritional value, Spirulina has been consumed as food for centuries in Central Africa. It is now widely used as nutraceutical food supplement worldwide. Recently, great attention and extensive studies have been devoted t...

journal_title：Cardiovascular therapeutics

authors： Deng R,Chow TJ

更新日期：2010-08-01 00:00:00

abstract：:Clopidogrel is an inhibitor of the ADP receptor P2Y12 and platelet aggregation. It is widely used for the management of atherothrombotic disease in patients who have experienced severe vascular events such as stroke or myocardial infarction or with peripheral artery disease. However, some patients show "resistance" to...

journal_title：Cardiovascular therapeutics

authors： Uchiyama S

更新日期：2011-12-01 00:00:00

abstract：:Potassium (K(+) ) channels are important in cardiovascular disease both as drug targets and as a cause of underlying pathology. Voltage-dependent K(+) (K(V) ) channels are inhibited by the class III antiarrhythmic agents. Certain vasodilators work by opening K(+) channels in vascular smooth muscle cells (VSMCs), and...

journal_title：Cardiovascular therapeutics

authors： Goonetilleke L,Quayle J

更新日期：2012-02-01 00:00:00

abstract：:Recent studies have shown that stromal cell derived factor-1 (SDF-1), first known as a cytokine involved in recruiting stem cells into injured organs, confers myocardial protection in myocardial infarction, which is not dependent on stem cell recruitment but related with modulation of ischemia-reperfusion (I/R) injury...

journal_title：Cardiovascular therapeutics

authors： Jang YH,Kim JH,Ban C,Ahn K,Cheong JH,Kim HH,Kim JS,Park YH,Kim J,Chun KJ,Lee GH,Kim M,Kim C,Xu Z

更新日期：2012-10-01 00:00:00

abstract：AIMS:Bariatric surgery has emerged as a promising treatment option for weight loss and to counter the metabolic consequences of obesity. Obesity has been linked to a hyperaggregable state, as well as a blunted response to aspirin. This pilot study assessed the hypothesis that bariatric surgery would lead to an improvem...

journal_title：Cardiovascular therapeutics

authors： Norgard NB,Monte SV,Fernandez SF,Ma Q

更新日期：2017-08-01 00:00:00

abstract：AIMS:We performed a multicenter, randomized controlled trial to determine the noninferiority of a novel biodegradable polymer drug-eluting stent (BP-DES), the EXCEL 2 stent, to the first-generation BP-DES, the EXCEL stent. METHODS AND RESULTS:Patients (n = 419) scheduled to undergo percutaneous coronary intervention (...

journal_title：Cardiovascular therapeutics

authors： Xu K,Han Y,Xu B,Yang Y,Wang G,Li H,Sun Y,Tao L,Wang H,Yuan Z,Liu H,Liu J,Jia Y,Ma G,Fu G,Li X,Li S,Wang S,Pu K,CREDIT 2 Investigators.

更新日期：2018-06-01 00:00:00

abstract：:Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) are standard procedures for dealing with severe aortic stenosis patients. Researchers have not carried out a systematic review of the volume-outcome relationship in TAVR and SAVR. Our study is intended to address this problem. W...

journal_title：Cardiovascular therapeutics

authors： He J,Zhang Z,Wang H,Cai L

更新日期：2020-04-18 00:00:00

abstract：:Cilnidipine is a unique Ca(2+) channel blocker with an inhibitory action on the sympathetic N-type Ca(2+) channels, which is used for patients with hypertension in Japan. Cilnidipine has been clarified to exert antisympathetic actions in various examinations from cell to human levels, in contrast to classical Ca(2+) c...

journal_title：Cardiovascular therapeutics

authors： Takahara A

更新日期：2009-07-01 00:00:00

abstract：AIM:To discuss the pathophysiology of iron metabolism in chronic heart failure (CHF) and the current knowledge of the efficacy of intravenous (IV) iron therapy in patients with CHF and identify points of controversy as well as highlight areas for future research. DISCUSSION:Iron deficiency is a recognized complication...

journal_title：Cardiovascular therapeutics

authors： Kang CK,Pope M,Lang CC,Kalra PR

更新日期：2017-12-01 00:00:00

abstract：Background:Atherosclerosis (AS) is a common severe disease around the world. The merging paper reported that long noncoding RNAs (lncRNAs) took part in diversified pathological processes of AS, although the mechanism remains unknown. This study is aimed at uncovering the profile of lncRNA taurine-upregulated gene 1 (TU...

journal_title：Cardiovascular therapeutics

authors： Tang Y,Hu J,Zhong Z,Liu Y,Wang Y

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Levosimendan is a noncatecholamine inotrope that does not increase oxygen consumption, utilized for the treatment for acute heart failure with left ventricular (LV) systolic dysfunction. Its use in takotsubo cardiomyopathy (TTC), a disease that contraindicates the use of catecholamine inotropes, is not well ...

journal_title：Cardiovascular therapeutics

authors： Santoro F,Ieva R,Ferraretti A,Ienco V,Carpagnano G,Lodispoto M,Di Biase L,Di Biase M,Brunetti ND

更新日期：2013-12-01 00:00:00

abstract：AIM:Previous studies and national assessments indicate an undertreatment of mineralocorticoid receptor antagonists (MRA) in heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate why MRA is not used to full extent. METHODS:A complete community-based heart failure population was studied. ...

journal_title：Cardiovascular therapeutics

authors： Jonsson A,Norberg H,Bergdahl E,Lindmark K

更新日期：2018-10-01 00:00:00

abstract：:Atherosclerosis is one of the major macrovascular complications of diabetes mellitus (DM), and it is the main cause of death from clinical observation. Among various cell types involved in this disorder, endothelial cells, vascular smooth muscle cells (VSMCs), and macrophages play a crucial role in the occurrence and ...

journal_title：Cardiovascular therapeutics

authors： Tang N,Jiang S,Yang Y,Liu S,Ponnusamy M,Xin H,Yu T

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Secondary pulmonary hypertension (PH) and right ventricular dysfunction are common and associated with poor prognosis in HF patients with left ventricular assist devices (LVADs). The role of pulmonary vasodilator therapy for these patients is currently unclear. AIMS:We sought to evaluate the safety and cl...

journal_title：Cardiovascular therapeutics

authors： LaRue SJ,Garcia-Cortes R,Nassif ME,Vader JM,Ray S,Ravichandran A,Rasalingham R,Silvestry SC,Ewald GA,Wang IW,Schilling JD

更新日期：2015-04-01 00:00:00