Abstract:
:Left ventricular hypertrophy (LVH) is a common and independent risk factor for cardiovascular events in patients with coronary artery disease (CAD). Controlling blood pressure is the standard approach to the management of LVH, but this is only partially effective as LVH also persists in normotensive patients. Apart from blood pressure (BP), other main risk factors associated with LVH are insulin resistance (IR) and central obesity. The diabetic medication, Metformin, reduces IR and aids weight loss and may therefore regress LVH. The MET REMODEL study will investigate the ability of Metformin to regress LVH in 64 patients with CAD. The MET-REMODEL trial is a single-center, phase IV, double blind, randomized, placebo-controlled trial to investigate the efficacy of Metformin in regression of the independent cardiac risk factor of LVH in patients with CAD who are insulin resistant. A minimum of 64 adults with a history of CAD with LVH and IR will be randomized into two groups to receive, either Metformin XL or placebo. The primary endpoint of this trial is to investigate any change in left ventricular mass index. Secondary endpoints include changes to insulin resistance measured using fasting insulin resistance index (FIRI), obesity, LV size, and function and improvement in endothelial function. A positive result will assist clinicians to identify a new mechanism for LVH regression by administering Metformin XL. This may also lead to investigating the mortality benefit of Metformin in patients with CAD and LVH.
journal_name
Cardiovasc Therjournal_title
Cardiovascular therapeuticsauthors
Mohan M,McSwiggan S,Baig F,Rutherford L,Lang CCdoi
10.1111/1755-5922.12101subject
Has Abstractpub_date
2015-02-01 00:00:00pages
1-8issue
1eissn
1755-5914issn
1755-5922journal_volume
33pub_type
杂志文章,随机对照试验abstract::Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance found in clinical practice, increasing in prevalence with age. AF is often associated with structural heart disease, although a significant proportion has no detectable heart disease. In the last 2 decades, there has been an increase of 6...
journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5922.2010.00216.x
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journal_title:Cardiovascular therapeutics
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,随机对照试验
doi:10.1111/1755-5922.12108
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journal_title:Cardiovascular therapeutics
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/1755-5922.12268
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/1755-5922.12458
更新日期:2018-10-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/1755-5922.12046
更新日期:2013-12-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
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更新日期:2021-01-02 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
doi:10.1111/1755-5922.12090
更新日期:2014-10-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/1755-5922.12224
更新日期:2016-12-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,meta分析
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更新日期:2020-04-23 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Doxorubicin (DOX) is an anthracycline antitumor drug. However, its clinical use is limited by dose-dependent cardiotoxicity and even progresses to chronic heart failure (CHF). OBJECTIVE:This study aims to investigate whether the Nrf2 activator, sulforaphane (SFN), can prevent DOX-induced CHF. METHODS:Male ...
journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/1755-5922.12277
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pub_type: 杂志文章,多中心研究
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,多中心研究
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更新日期:2016-06-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
doi:10.1111/1755-5922.12301
更新日期:2017-12-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/j.1755-5922.2011.00264.x
更新日期:2012-08-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
doi:10.1111/1755-5922.12032
更新日期:2013-12-01 00:00:00
abstract:AIM:Cardiac hypertrophy and myocardial fibrosis significantly contribute to the pathogenesis of diabetic cardiomyopathy (DCM). Altered expression of several genes and their regulation by microRNAs has been reported in hypertrophied failing hearts. This study aims to examine the role of Cdc42, Pak1, and miR-30c in the p...
journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/1755-5922.12113
更新日期:2015-06-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章
doi:10.1111/j.1755-5922.2010.00203.x
更新日期:2011-08-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5922.2008.00065.x
更新日期:2008-01-01 00:00:00
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journal_title:Cardiovascular therapeutics
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-04-01 00:00:00