Clinical application of adult stem cells for therapy for cardiac disease.

abstract：:Patients with coronary artery disease (CAD) commonly have varying degrees of coexisting cerebrovascular disease (CVD) and chronic kidney disease (CKD), and proper management is complicated partly because of a lack of unifying guidelines. The aim of this article is to review the current literature and propose the optim...

journal_title：Cardiovascular therapeutics

authors： Notaro LA,Usman MH,Burke JF,Siddiqui A,Superdock KR,Ezekowitz MD

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Left ventricular outflow tract obstruction (LVOTO) may complicate an episode of Takotsubo cardiomyopathy (TTC), potentially leading to cardiogenic shock. Beta-blockers are considered the most suitable treatment for such complication. AIM OF THE STUDY:The objective of this study was to evaluate the hemodynam...

journal_title：Cardiovascular therapeutics

authors： Santoro F,Ieva R,Ferraretti A,Fanelli M,Musaico F,Tarantino N,Martino LD,Gennaro LD,Caldarola P,Biase MD,Brunetti ND

更新日期：2016-06-01 00:00:00

abstract：:There is increasing evidence to suggest that chronic heart failure (CHF) is an insulin resistant (IR) state and that the degree of IR correlates with the severity and mortality of CHF. The pathophysiology of IR in CHF has yet to be fully defined. Additionally, it remains to be determined if IR is merely a marker refle...

journal_title：Cardiovascular therapeutics

authors： Wong AK,AlZadjali MA,Choy AM,Lang CC

更新日期：2008-10-01 00:00:00

abstract：:Cilnidipine is a unique Ca(2+) channel blocker with an inhibitory action on the sympathetic N-type Ca(2+) channels, which is used for patients with hypertension in Japan. Cilnidipine has been clarified to exert antisympathetic actions in various examinations from cell to human levels, in contrast to classical Ca(2+) c...

journal_title：Cardiovascular therapeutics

authors： Takahara A

更新日期：2009-07-01 00:00:00

abstract：Background:Atherosclerosis (AS) is a common severe disease around the world. The merging paper reported that long noncoding RNAs (lncRNAs) took part in diversified pathological processes of AS, although the mechanism remains unknown. This study is aimed at uncovering the profile of lncRNA taurine-upregulated gene 1 (TU...

journal_title：Cardiovascular therapeutics

authors： Tang Y,Hu J,Zhong Z,Liu Y,Wang Y

更新日期：2020-05-29 00:00:00

abstract：INTRODUCTION:Rap1, a member of Ras superfamily of small GTP-binding proteins, is involved in cardiovascular biology in numerous ways. It is an evolutionary conserved regulator of adhesion, polarity, differentiation and growth. AIMS:Our aim was to analyze Rap1-activated rat bone marrow mesenchymal stem cells (MSCs) for...

journal_title：Cardiovascular therapeutics

authors： Khan I,Ali A,Akhter MA,Naeem N,Chotani MA,Iqbal H,Kabir N,Atiq M,Salim A

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIM:Warfarin treatment discontinuation is significant among patients with atrial fibrillation (AF). Studies mainly focused on whether the proportion of warfarin persistence and discontinuation are clinically appropriate are absent. This study evaluates warfarin persistence with focus on predictors for, a...

journal_title：Cardiovascular therapeutics

authors： Björck F,Ek A,Johansson L,Själander A

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The antianginal agent ranolazine (R) has shown some promise as an antiarrhythmic agent but its mechanism of action is not known. Previously, we have shown that R suppresses ventricular arrhythmias at a concentration >10 μM that may affect multiple ion currents including IKr. PURPOSE:The present study was ca...

journal_title：Cardiovascular therapeutics

authors： Kloner RA,Dow JS,Bhandari A

更新日期：2011-08-01 00:00:00

abstract：:Acute coronary syndrome (ACS) is a medical emergency often associated with an occlusive coronary event with consequent myocardial underperfusion. Patients require immediate antiplatelet therapy and long-term antithrombotic prophylaxis to reduce the risk of recurrence. Acetylsalicylic acid (ASA) alone or in combination...

journal_title：Cardiovascular therapeutics

authors： Cohen M,Iyer D

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:The effectiveness of statin pretreatment in reducing the incidence of contrast-induced nephropathy (CIN) has been examined in some observational and randomized studies, yielding controversial results. AIM:This study sought to evaluate the role of atorvastatin in prevention of CIN in diabetic patients with...

journal_title：Cardiovascular therapeutics

authors： Shehata M,Hamza M

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:The metabolic modulator trimetazidine (TMZ) has been suggested to induce a metabolic shift from myocardial fatty acid oxidation (FAO) to glucose utilization, but this mechanism remains unproven in humans. The oxidation of plasma derived FA is commonly measured in humans, whereas the contribution of FA from...

journal_title：Cardiovascular therapeutics

authors： Bucci M,Borra R,Någren K,Pärkkä JP,Del Ry S,Maggio R,Tuunanen H,Viljanen T,Cabiati M,Rigazio S,Taittonen M,Pagotto U,Parkkola R,Opie LH,Nuutila P,Knuuti J,Iozzo P

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage (ICH) is the most fearful side effect of oral anticoagulant therapy. It is still unclear which risk factor is involved in ICH during vitamin K antagonists (VKAs) treatment and if commonly used bleeding risk scores are able to predict ICH. PURPOSE:Search for individual risk factors an...

journal_title：Cardiovascular therapeutics

authors： Zanella L,Zoppellaro G,Marigo L,Denas G,Padayattil Jose S,Pengo V

更新日期：2018-10-01 00:00:00

abstract：:The mitochondrial F1F0 ATP synthase is responsible for the majority of ATP production in mammals and does this through a rotary catalytic mechanism. Studies show that the F1F0 ATP synthase can switch to an ATP hydrolase, and this occurs under conditions seen during myocardial ischemia. This ATP hydrolysis causes wasti...

journal_title：Cardiovascular therapeutics

authors： Grover GJ,Malm J

更新日期：2008-01-01 00:00:00

abstract：:Alternative medications as a term call up many different meanings, significance, and perceptions to various medical practitioners. Some are good; others are bad. A wide range of alternative medications with relevance or connection to cardiovascular (CV) disease have been considered. While many are worthless, others ha...

journal_title：Cardiovascular therapeutics

authors： Whayne TF Jr

更新日期：2010-04-01 00:00:00

abstract：AIMS:We performed a multicenter, randomized controlled trial to determine the noninferiority of a novel biodegradable polymer drug-eluting stent (BP-DES), the EXCEL 2 stent, to the first-generation BP-DES, the EXCEL stent. METHODS AND RESULTS:Patients (n = 419) scheduled to undergo percutaneous coronary intervention (...

journal_title：Cardiovascular therapeutics

authors： Xu K,Han Y,Xu B,Yang Y,Wang G,Li H,Sun Y,Tao L,Wang H,Yuan Z,Liu H,Liu J,Jia Y,Ma G,Fu G,Li X,Li S,Wang S,Pu K,CREDIT 2 Investigators.

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Acute kidney injury is a frequent problem among many critically ill patients, commonly in the context of multiple organ failure and decreased renal perfusion. Its presence conveys a poor prognosis. Currently, effective therapeutic interventions are limited and dopaminergic agonists have been suggested as an ...

journal_title：Cardiovascular therapeutics

authors： Cobas M,Paparcuri G,De La Pena M,Cudemus G,Barquist E,Varon A

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Secondary pulmonary hypertension (PH) and right ventricular dysfunction are common and associated with poor prognosis in HF patients with left ventricular assist devices (LVADs). The role of pulmonary vasodilator therapy for these patients is currently unclear. AIMS:We sought to evaluate the safety and cl...

journal_title：Cardiovascular therapeutics

authors： LaRue SJ,Garcia-Cortes R,Nassif ME,Vader JM,Ray S,Ravichandran A,Rasalingham R,Silvestry SC,Ewald GA,Wang IW,Schilling JD

更新日期：2015-04-01 00:00:00

abstract：AIMS:Bariatric surgery has emerged as a promising treatment option for weight loss and to counter the metabolic consequences of obesity. Obesity has been linked to a hyperaggregable state, as well as a blunted response to aspirin. This pilot study assessed the hypothesis that bariatric surgery would lead to an improvem...

journal_title：Cardiovascular therapeutics

authors： Norgard NB,Monte SV,Fernandez SF,Ma Q

更新日期：2017-08-01 00:00:00

abstract：:Spirulina is free-floating filamentous microalgae growing in alkaline water bodies. With its high nutritional value, Spirulina has been consumed as food for centuries in Central Africa. It is now widely used as nutraceutical food supplement worldwide. Recently, great attention and extensive studies have been devoted t...

journal_title：Cardiovascular therapeutics

authors： Deng R,Chow TJ

更新日期：2010-08-01 00:00:00

abstract：:Potassium (K(+) ) channels are important in cardiovascular disease both as drug targets and as a cause of underlying pathology. Voltage-dependent K(+) (K(V) ) channels are inhibited by the class III antiarrhythmic agents. Certain vasodilators work by opening K(+) channels in vascular smooth muscle cells (VSMCs), and...

journal_title：Cardiovascular therapeutics

authors： Goonetilleke L,Quayle J

更新日期：2012-02-01 00:00:00

abstract：AIM:Data evaluating the complications of pulmonary vein isolation (PVI) using second-generation cryoballoons (CB) related to different anticoagulation regimes are limited. This study evaluates the total complications and the impact of novel oral anticoagulants (NOACs) compared to phenprocoumon on adverse events in the ...

journal_title：Cardiovascular therapeutics

authors： Koektuerk B,Turan CH,Yorgun H,Keskin K,Schoett M,Dahmen A,Gorr E,Yang A,Hoppe C,Horlitz M,Turan RG

更新日期：2016-06-01 00:00:00

abstract：:In patients with ischemic heart disease, the goal of cell therapy is to improve perfusion and function of the damaged heart muscle. For this review, we selected articles that reported the findings from the major clinical studies of cardiovascular stem cell therapy in patients with chronic ischemic heart disease. Becau...

journal_title：Cardiovascular therapeutics

authors： Perin EC,Silva GV

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Aspirin resistance is associated with increased cardiovascular risk in aspirin-treated patients. Poor compliance may explain many cases of "resistance," yet few clinical studies have used objective measurement of therapy compliance. We did so in a case-controlled study. METHODS:We enrolled patients within...

journal_title：Cardiovascular therapeutics

authors： Dawson J,Quinn T,Rafferty M,Higgins P,Ray G,Lees KR,Walters MR

更新日期：2011-10-01 00:00:00

abstract：:Accelerated atherosclerosis and microvascular complications are the leading causes of coronary heart disease, stroke, blindness, and end-stage renal failure, which could account for disabilities and high mortality rates in patients with diabetes. Recent clinical studies have substantiated the concept of "hyperglycemic...

journal_title：Cardiovascular therapeutics

authors： Yamagishi S,Nakamura K,Matsui T,Ueda S,Noda Y,Imaizumi T

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:Endothelial progenitor cells (EPCs) have been shown to participate in the process of vascular repair, thus playing a protective role against cardiovascular disease (CVD). It is known that atherosclerotic risk factors could affect EPC number and function. Advanced glycation end products (AGEs) contribute to t...

journal_title：Cardiovascular therapeutics

authors： Ueda S,Yamagishi S,Matsui T,Noda Y,Ueda S,Jinnouchi Y,Sasaki K,Takeuchi M,Imaizumi T

更新日期：2012-08-01 00:00:00

abstract：AIM:To discuss the pathophysiology of iron metabolism in chronic heart failure (CHF) and the current knowledge of the efficacy of intravenous (IV) iron therapy in patients with CHF and identify points of controversy as well as highlight areas for future research. DISCUSSION:Iron deficiency is a recognized complication...

journal_title：Cardiovascular therapeutics

authors： Kang CK,Pope M,Lang CC,Kalra PR

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:In two, 6-month, randomized, double-blind Phase 3 trials, PA32540 (enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) compared to aspirin alone was associated with fewer endoscopic gastric and duodenal ulcers in patients requiring aspirin therapy for secondary cardiovascular disease (CVD...

journal_title：Cardiovascular therapeutics

authors： Goldstein JL,Whellan DJ,Scheiman JM,Cryer BL,Eisen GM,Lanas A,Fort JG

更新日期：2016-04-01 00:00:00

abstract：AIMS:This study aimed to assess prescribers' monitoring for arrhythmic risk with QT-prolonging medications (LQT drugs). METHODS:Over a 6-month period, all inpatients under the care of Cardiologists (Cohort A) and General Physicians (Cohort B) at Aberdeen Royal Infirmary who were prescribed drugs with known risk of Tor...

journal_title：Cardiovascular therapeutics

authors： Choo WK,Turpie D,Milne K,Davidson L,Elofuke P,Whitfield J,Broadhurst P

更新日期：2014-10-01 00:00:00

abstract：:The pericardium is composed of visceral and parietal components. In view of the pericardium's simple structure, pathologic processes involving it are understandably few. However, despite a limited number of clinical syndromes, the pericardium is affected by virtually every category of disease, including infectious, ne...

journal_title：Cardiovascular therapeutics

authors： Azam S,Hoit BD

更新日期：2011-10-01 00:00:00

abstract：Objective:The drug efficacy may differ among different statins, and evidence from head-to-head comparisons is sparse and inconsistent. The study is aimed at comparing the lipid-lowering/increasing effects of 7 different statins in patients with dyslipidemia, cardiovascular diseases, or diabetes mellitus by conducting s...

journal_title：Cardiovascular therapeutics

authors： Zhang X,Xing L,Jia X,Pang X,Xiang Q,Zhao X,Ma L,Liu Z,Hu K,Wang Z,Cui Y

更新日期：2020-04-23 00:00:00