Epac-Rap1-activated mesenchymal stem cells improve cardiac function in rat model of myocardial infarction.

abstract：:This study aimed to investigate the correlation between complement C1q tumor necrosis factor-related protein 1 (CTRP1) and subclinical target organ damage (STOD) in essential hypertension (EH). 720 patients were enrolled in this study, including 360 healthy subjects and 360 patients with EH. The EH group included 183 ...

journal_title：Cardiovascular therapeutics

authors： Su Z,Tian S,Liang W

更新日期：2019-06-02 00:00:00

abstract：:Atrial fibrillation (AF) is very common within the first 5 days of cardiac surgery. It is associated with significant morbidity including stroke, ventricular arrhythmias, myocardial infarction, heart failure, acute kidney injury, prolonged hospital stay, and also short- and long-term mortality. The underlying mechanis...

journal_title：Cardiovascular therapeutics

authors： Ho KM,Lewis JP

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:The effectiveness of statin pretreatment in reducing the incidence of contrast-induced nephropathy (CIN) has been examined in some observational and randomized studies, yielding controversial results. AIM:This study sought to evaluate the role of atorvastatin in prevention of CIN in diabetic patients with...

journal_title：Cardiovascular therapeutics

authors： Shehata M,Hamza M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Doxorubicin (DOX) is an anthracycline antitumor drug. However, its clinical use is limited by dose-dependent cardiotoxicity and even progresses to chronic heart failure (CHF). OBJECTIVE:This study aims to investigate whether the Nrf2 activator, sulforaphane (SFN), can prevent DOX-induced CHF. METHODS:Male ...

journal_title：Cardiovascular therapeutics

authors： Bai Y,Chen Q,Sun YP,Wang X,Lv L,Zhang LP,Liu JS,Zhao S,Wang XL

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND AIM:Warfarin treatment discontinuation is significant among patients with atrial fibrillation (AF). Studies mainly focused on whether the proportion of warfarin persistence and discontinuation are clinically appropriate are absent. This study evaluates warfarin persistence with focus on predictors for, a...

journal_title：Cardiovascular therapeutics

authors： Björck F,Ek A,Johansson L,Själander A

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Secondary pulmonary hypertension (PH) and right ventricular dysfunction are common and associated with poor prognosis in HF patients with left ventricular assist devices (LVADs). The role of pulmonary vasodilator therapy for these patients is currently unclear. AIMS:We sought to evaluate the safety and cl...

journal_title：Cardiovascular therapeutics

authors： LaRue SJ,Garcia-Cortes R,Nassif ME,Vader JM,Ray S,Ravichandran A,Rasalingham R,Silvestry SC,Ewald GA,Wang IW,Schilling JD

更新日期：2015-04-01 00:00:00

abstract：:The mitochondrial F1F0 ATP synthase is responsible for the majority of ATP production in mammals and does this through a rotary catalytic mechanism. Studies show that the F1F0 ATP synthase can switch to an ATP hydrolase, and this occurs under conditions seen during myocardial ischemia. This ATP hydrolysis causes wasti...

journal_title：Cardiovascular therapeutics

authors： Grover GJ,Malm J

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Inflammation after myocardial infarction (MI) causes cardiac nerve sprouting and consequent ventricular arrhythmias (VAs). Macrophages, as major immune cells, are involved in the entire inflammation response process and serve as a link between inflammation and sympathetic hyperinnervation by regulating nerve...

journal_title：Cardiovascular therapeutics

authors： Yang N,Cheng W,Hu H,Xue M,Li X,Wang Y,Xuan Y,Li X,Yin J,Shi Y,Yan S

更新日期：2016-08-01 00:00:00

abstract：:Potassium (K(+) ) channels are important in cardiovascular disease both as drug targets and as a cause of underlying pathology. Voltage-dependent K(+) (K(V) ) channels are inhibited by the class III antiarrhythmic agents. Certain vasodilators work by opening K(+) channels in vascular smooth muscle cells (VSMCs), and...

journal_title：Cardiovascular therapeutics

authors： Goonetilleke L,Quayle J

更新日期：2012-02-01 00:00:00

abstract：AIMS:We investigated the relative pharmacokinetics, pharmacodynamics, and safety of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor alirocumab following injection at three different sites. METHODS:Sixty healthy subjects (39 male, 21 female; age 20-45 years) were randomized to receive a single subcu...

journal_title：Cardiovascular therapeutics

authors： Lunven C,Paehler T,Poitiers F,Brunet A,Rey J,Hanotin C,Sasiela WJ

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Real-world, country-specific studies of dual antiplatelet therapy (DAPT) duration among survivors of acute coronary syndrome (ACS) are important for improving long-term prognosis. AIMS:To investigate DAPT duration after hospital discharge for ACS in Spain. RESULTS:Data from patients enrolled in the Spani...

journal_title：Cardiovascular therapeutics

authors： Bardají A,Leal M,Arrarte V,Garcia-Moll X,Pérez de Isla L,Bueno H

更新日期：2017-04-01 00:00:00

abstract：:Patients with coronary artery disease (CAD) commonly have varying degrees of coexisting cerebrovascular disease (CVD) and chronic kidney disease (CKD), and proper management is complicated partly because of a lack of unifying guidelines. The aim of this article is to review the current literature and propose the optim...

journal_title：Cardiovascular therapeutics

authors： Notaro LA,Usman MH,Burke JF,Siddiqui A,Superdock KR,Ezekowitz MD

更新日期：2009-10-01 00:00:00

abstract：:Morbidity of patients with cardiac syndrome X (typical anginal-like chest pain and normal coronary arteriogram) is high with continuing episodes of chest pain and frequent hospital readmissions. Management of this syndrome represents a major challenge for the treating physician. Conventional therapies with antianginal...

journal_title：Cardiovascular therapeutics

authors： Lim TK,Choy AJ,Khan F,Belch JJ,Struthers AD,Lang CC

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Nonadherence to secondary preventative medications after stroke is common and is associated with poor outcomes. Numerous strategies exist to promote adherence. We performed a systematic review and meta-analysis to describe the efficacy of strategies to improve adherence to stroke secondary prevention. MET...

journal_title：Cardiovascular therapeutics

authors： Al AlShaikh S,Quinn T,Dunn W,Walters M,Dawson J

更新日期：2016-04-01 00:00:00

abstract：AIM:This study was designed to explore the mechanism of physiological ischemic training (PIT) on remote limbs, with a special focus on the potential role of endothelial progenitor cells (EPCs), vascular endothelial growth factor (VEGF), and nitric oxide (NO) in local ischemic myocardium. METHOD:Myocardial ischemia (MI...

journal_title：Cardiovascular therapeutics

authors： Zheng Y,Xiao M,Li L,Li J,Reinhardt JD,Lu X

更新日期：2017-06-01 00:00:00

abstract：:Sex-specific differences have been definitively demonstrated in cardiovascular (CV) diseases. These differences can also impact on the effects of CV therapies. Female sex is recognized as an independent predictor of thromboembolic risk, particularly in older patients. Most of strokes are due to atrial fibrillation (AF...

journal_title：Cardiovascular therapeutics

authors： Gallù M,Marrone G,Legramante JM,De Lorenzo A,Di Daniele N,Noce A

更新日期：2020-06-18 00:00:00

abstract：AIM:Previous studies and national assessments indicate an undertreatment of mineralocorticoid receptor antagonists (MRA) in heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate why MRA is not used to full extent. METHODS:A complete community-based heart failure population was studied. ...

journal_title：Cardiovascular therapeutics

authors： Jonsson A,Norberg H,Bergdahl E,Lindmark K

更新日期：2018-10-01 00:00:00

abstract：AIMS:Insulin promotes Akt-dependent prosurvival signaling and reduces experimental ischemia reperfusion injury, but its clinical impact has been limited. Further understanding of the interplay between insulin and Akt in the myocardium of relevant large animal models is needed. We aimed to investigate (1) Akt phosphoryl...

journal_title：Cardiovascular therapeutics

authors： Slettom G,Jonassen AK,Breivik L,Seifert R,Nordrehaug JE

更新日期：2013-12-01 00:00:00

abstract：AIMS:We performed a multicenter, randomized controlled trial to determine the noninferiority of a novel biodegradable polymer drug-eluting stent (BP-DES), the EXCEL 2 stent, to the first-generation BP-DES, the EXCEL stent. METHODS AND RESULTS:Patients (n = 419) scheduled to undergo percutaneous coronary intervention (...

journal_title：Cardiovascular therapeutics

authors： Xu K,Han Y,Xu B,Yang Y,Wang G,Li H,Sun Y,Tao L,Wang H,Yuan Z,Liu H,Liu J,Jia Y,Ma G,Fu G,Li X,Li S,Wang S,Pu K,CREDIT 2 Investigators.

更新日期：2018-06-01 00:00:00

abstract：:Atherosclerosis is one of the major macrovascular complications of diabetes mellitus (DM), and it is the main cause of death from clinical observation. Among various cell types involved in this disorder, endothelial cells, vascular smooth muscle cells (VSMCs), and macrophages play a crucial role in the occurrence and ...

journal_title：Cardiovascular therapeutics

authors： Tang N,Jiang S,Yang Y,Liu S,Ponnusamy M,Xin H,Yu T

更新日期：2018-08-01 00:00:00

abstract：:In patients with ischemic heart disease, the goal of cell therapy is to improve perfusion and function of the damaged heart muscle. For this review, we selected articles that reported the findings from the major clinical studies of cardiovascular stem cell therapy in patients with chronic ischemic heart disease. Becau...

journal_title：Cardiovascular therapeutics

authors： Perin EC,Silva GV

更新日期：2011-06-01 00:00:00

abstract：:Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) are standard procedures for dealing with severe aortic stenosis patients. Researchers have not carried out a systematic review of the volume-outcome relationship in TAVR and SAVR. Our study is intended to address this problem. W...

journal_title：Cardiovascular therapeutics

authors： He J,Zhang Z,Wang H,Cai L

更新日期：2020-04-18 00:00:00

abstract：:The genetic causes of cholesterol metabolism disorders usually lead to premature atherosclerosis. The most well recognized genetically caused hypercholesterolemia is familial hypercholesterolemia. Although the disease is well known, as the discovery of low-density lipoprotein receptor, the classical treatment with lip...

journal_title：Cardiovascular therapeutics

authors： Kolovou G,Vasiliadis I,Gontoras N,Kolovou V,Hatzigeorgiou G

更新日期：2015-04-01 00:00:00

abstract：AIM:To discuss the pathophysiology of iron metabolism in chronic heart failure (CHF) and the current knowledge of the efficacy of intravenous (IV) iron therapy in patients with CHF and identify points of controversy as well as highlight areas for future research. DISCUSSION:Iron deficiency is a recognized complication...

journal_title：Cardiovascular therapeutics

authors： Kang CK,Pope M,Lang CC,Kalra PR

更新日期：2017-12-01 00:00:00

abstract：AIM:Cardiac hypertrophy and myocardial fibrosis significantly contribute to the pathogenesis of diabetic cardiomyopathy (DCM). Altered expression of several genes and their regulation by microRNAs has been reported in hypertrophied failing hearts. This study aims to examine the role of Cdc42, Pak1, and miR-30c in the p...

journal_title：Cardiovascular therapeutics

authors： Raut SK,Kumar A,Singh GB,Nahar U,Sharma V,Mittal A,Sharma R,Khullar M

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Options for a pharmacological cardioversion (CV) of short-duration atrial fibrillation (AF) in patients with a stable coronary artery disease (CAD) are limited to amiodarone or vernakalant. Antazoline has been reported to achieve high rates of AF conversion to sinus rhythm, but data on its effectiveness an...

journal_title：Cardiovascular therapeutics

authors： Farkowski MM,Maciag A,Zurawska M,Kowalik I,Szwed H,Pytkowski M

更新日期：2018-12-01 00:00:00

abstract：:There is increasing evidence to suggest that chronic heart failure (CHF) is an insulin resistant (IR) state and that the degree of IR correlates with the severity and mortality of CHF. The pathophysiology of IR in CHF has yet to be fully defined. Additionally, it remains to be determined if IR is merely a marker refle...

journal_title：Cardiovascular therapeutics

authors： Wong AK,AlZadjali MA,Choy AM,Lang CC

更新日期：2008-10-01 00:00:00

abstract：AIM:Data evaluating the complications of pulmonary vein isolation (PVI) using second-generation cryoballoons (CB) related to different anticoagulation regimes are limited. This study evaluates the total complications and the impact of novel oral anticoagulants (NOACs) compared to phenprocoumon on adverse events in the ...

journal_title：Cardiovascular therapeutics

authors： Koektuerk B,Turan CH,Yorgun H,Keskin K,Schoett M,Dahmen A,Gorr E,Yang A,Hoppe C,Horlitz M,Turan RG

更新日期：2016-06-01 00:00:00

abstract：:The pericardium is composed of visceral and parietal components. In view of the pericardium's simple structure, pathologic processes involving it are understandably few. However, despite a limited number of clinical syndromes, the pericardium is affected by virtually every category of disease, including infectious, ne...

journal_title：Cardiovascular therapeutics

authors： Azam S,Hoit BD

更新日期：2011-10-01 00:00:00

abstract：:Clopidogrel is an inhibitor of the ADP receptor P2Y12 and platelet aggregation. It is widely used for the management of atherothrombotic disease in patients who have experienced severe vascular events such as stroke or myocardial infarction or with peripheral artery disease. However, some patients show "resistance" to...

journal_title：Cardiovascular therapeutics

authors： Uchiyama S

更新日期：2011-12-01 00:00:00