Abstract:
:Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent cells accumulate in multiple organs during ageing, contribute to tissue dysfunction and give rise to pathological manifestations. Senescence is therefore a defining feature of a variety of human age-related disorders, including cancer, and targeted elimination of these cells has recently emerged as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration. In addition, in vivo identification of senescent cells has significant potential for early diagnosis of multiple pathologies. Here, we review existing senolytics, small molecules and drug delivery tools used in preclinical therapeutic strategies involving cellular senescence, as well as probes to trace senescent cells. We also review the clinical research landscape in senescence and discuss how identifying and targeting cellular senescence might positively affect pathological and ageing processes.
journal_name
EMBO Mol Medjournal_title
EMBO molecular medicineauthors
Paez-Ribes M,González-Gualda E,Doherty GJ,Muñoz-Espín Ddoi
10.15252/emmm.201810234subject
Has Abstractpub_date
2019-12-01 00:00:00pages
e10234issue
12eissn
1757-4676issn
1757-4684journal_volume
11pub_type
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