Abstract:
STUDY DESIGN:Experimental study with human mesenchymal stem cells (MSCs) and intervertebral disc (IVD) tissue samples. OBJECTIVE:This study aimed to characterize the effect of MSC homing on the Tie2-positive IVD progenitor cell population, IVD cell survival, and proliferation. SUMMARY OF BACKGROUND DATA:Homing of human MSCs has been described as potential alternative to MSC injection, aiming to enhance the regenerative capacity of the IVD. IVD cells expressing Tie2 (also known as CD202b or Angiopoietin-1 receptor TEK tyrosine kinase) represent a progenitor cell population with discogenic differentiation potential. However, the fraction of Tie2-positive progenitor cells decreases with aging and degree of IVD degeneration, resulting in a potential loss of the IVD's regenerative capacity. METHODS:Human MSCs, isolated from vertebral bone marrow aspirates, were labeled and seeded onto the endplate of bovine IVDs and human IVD tissue. Following MSC migration for 5 days, IVD cells were isolated by tissue digestion. The fractions of Tie2-positive, dead, apoptotic, and proliferative IVD cells were evaluated by flow cytometry and compared to untreated IVDs. For human IVDs, 3 groups were investigated: nondegenerated (organ donors), IVDs of patients suffering from spinal trauma, and degenerative IVD tissue samples. RESULTS:MSC homing enhanced the fraction of Tie2-positive IVD cells in bovine and human IVD samples. Furthermore, a proliferative response and lower fraction of dead cells were observed after MSC homing in both bovine and human IVD tissues. CONCLUSION:Our findings indicate that MSC homing enhances the survival and regenerative capability of IVD cells, which may be mediated by intercellular communication. MSC homing could represent a potential treatment strategy to prevent the onset of the degenerative cascade in IVDs at risk such as IVDs adjacent to a fused segment or IVDs after herniation. LEVEL OF EVIDENCE:N/A.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Wangler S,Peroglio M,Menzel U,Benneker LM,Haglund L,Sakai D,Alini M,Grad Sdoi
10.1097/BRS.0000000000003150subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1613-1622issue
23eissn
0362-2436issn
1528-1159pii
00007632-201912010-00002journal_volume
44pub_type
杂志文章相关文献
SPINE文献大全abstract::The prospective study was undertaken to find out preoperative or perioperative factors predicting the results of the first surgery for lumbar disc herniation. The results were evaluated 1 and 6 months postoperatively using, in addition to the patient evaluation, indices for pain, activities of daily living (ADL), and ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198711000-00016
更新日期:1987-11-01 00:00:00
abstract:STUDY DESIGN:Structural investigation of mechanically induced herniations in ovine lumbar motion segments. OBJECTIVE:This new study addresses the question of whether there are regions other than the posterior and posterolateral aspects that are implicated in the initiation of disc disruption and herniation. SUMMARY O...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002181
更新日期:2017-11-01 00:00:00
abstract:STUDY DESIGN:Multi-center, retrospective cohort study. OBJECTIVE:To determine the epidemiology, identify predictors of early mortality, and develop predictive models for traumatic spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA:Despite improved initial care and management strategies, traumatic SCI remains a deva...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000002871
更新日期:2019-04-01 00:00:00
abstract:STUDY DESIGN:Retrospective review of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database years 2010 to 2015. OBJECTIVE:Investigate which short-term outcomes differ for cervical laminoplasty and laminectomy and fusion surgeries. SUMMARY OF BACKGROUND DATA:Conflicting rep...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003057
更新日期:2019-09-01 00:00:00
abstract:STUDY DESIGN:A family-based study. OBJECTIVE:The aim of this study was to identify rare genetic factors predisposing to Modic changes (MCs). SUMMARY OF BACKGROUND DATA:Lumbar disc degeneration (LDD) is one of the contributing factors behind low back pain (LBP). Lumbar MC visualized as bone marrow signal intensity cha...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002049
更新日期:2017-08-15 00:00:00
abstract:STUDY DESIGN:Rat posterolateral lumbar fusion model. OBJECTIVE:To compare the efficacy of freshly isolated adipose tissue-derived stromal vascular fraction (A-SVF) and bone marrow cells (BMC) cells in achieving spinal fusion in a rat model. SUMMARY OF BACKGROUND DATA:Adipose tissue-derived stromal cells (ASCs) offer ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003709
更新日期:2020-09-24 00:00:00
abstract:STUDY DESIGN:Laboratory study. OBJECTIVE:Evaluate the effect of substance P (SP) on an intervertebral disc rat organ culture model. SUMMARY OF BACKGROUND DATA:Monolayer cell experiments have demonstrated that exposure intervertebral disc tissue cells to SP leads to upregulation in inflammatory cytokine expression; ho...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001676
更新日期:2016-12-15 00:00:00
abstract:STUDY DESIGN:Prospective case series of nine children with early-onset scoliosis (EOS) treated by a single surgeon with a novel implant, the magnet-driven growing rod (MdGR) in a publicly funded health care service accounting for "payer costs" (PC) incurred. OBJECTIVE:The aim of this study was to compare the cost-effe...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002738
更新日期:2019-01-01 00:00:00
abstract:STUDY DESIGN:A prospective cohort study. OBJECTIVE:To establish outcome measures for recovery and chronic pain for studies with patients who present with recent-onset acute low back pain (LBP) in primary care. SUMMARY OF BACKGROUND DATA:Among back pain researchers, no consensus exists about outcome definitions or how...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31820c01a6
更新日期:2011-12-15 00:00:00
abstract:STUDY DESIGN:A cross sectional multicenter study in six outpatient Rehabilitation Centers (RCs) in the Netherlands. OBJECTIVE:This study aims to confirm or refute the finding that a strong relationship exists between psychosocial distress and self-reported disability in patients with nonspecific chronic low back pain ...
journal_title:Spine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/BRS.0b013e3181e8af83
更新日期:2011-05-20 00:00:00
abstract:STUDY DESIGN:An ongoing prospective nonrandomized trial was conducted with 146 patients who underwent anterior cervical fusion with a bone graft substitute. The results for 78 patients followed up a minimum of 2 years are reported by an independent observer. OBJECTIVE:To investigate the clinical efficacy and osseointe...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/00007632-200205150-00008
更新日期:2002-05-15 00:00:00
abstract:STUDY DESIGN:The authors prospectively evaluated 40 patients with paralytic scoliosis treated from 1985 to 1990 with bilateral posterior segmental instrumentation, facet fusions, local bone graft, and allograft (mostly fresh frozen) bone supplementation only. OBJECTIVES:The authors report the fusion results for these ...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:STUDY DESIGN:Systematic review and meta-analysis. OBJECTIVE:To compare the efficacy of the use of either bisphosphonates or teriparatide on radiographic and functional outcomes of patients that had thoracolumbar spinal fusion. SUMMARY OF BACKGROUND DATA:Controversy exists as to whether bisphosphonates interfere with ...
journal_title:Spine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/BRS.0000000000002608
更新日期:2018-09-01 00:00:00
abstract::We used survivorship analysis to study 21 burst fractures that were treated with posterior VSP spine implant and fusion, each of which was over two motion segments. There were two treatment classes: 1) eight patients whose surgery included anterior bone grafting (augmentation), seven of which were done by the transped...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract:STUDY DESIGN:A retrospective analysis of collected data. OBJECTIVE:Our study aims to present the morphology of cranial-cervical spinal canal in basilar invagination (BI) patients. SUMMARY OF BACKGROUND DATA:BI is characterized by protrusion of the odontoid process into the foramen magnum (C0), leading to compression ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002706
更新日期:2018-11-15 00:00:00
abstract:STUDY DESIGN:A review of a clinical series was performed. OBJECTIVE:To assess the effectiveness of orthotic treatment in male patients with idiopathic scoliosis and to compare with published data on female patients. SUMMARY OF BACKGROUND DATA:Although males have been included in bracing studies, the number of males h...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200109150-00013
更新日期:2001-09-15 00:00:00
abstract:STUDY DESIGN:To analyze the effects of tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma on cauda equina function and to define if any of these cytokines could induce nerve root dysfunction comparable with the situation with application of nucleus pulposus. SUMMARY OF BACKGROUND DATA:Proinflammatory...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200208010-00004
更新日期:2002-08-01 00:00:00
abstract:STUDY DESIGN:A retrospective case-control study. OBJECTIVE:This study aimed to elucidate the association between facet joint orientation and degenerative lumbar spinal stenosis (DLSS). SUMMARY OF BACKGROUND DATA:Many studies have demonstrated the relationship between sagittal facet orientation and degenerative lumbar...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002493
更新日期:2018-07-15 00:00:00
abstract:STUDY DESIGN:A randomized, controlled clinical trial. OBJECTIVE:This randomized controlled clinical trial was aimed at comparing the clinical outcomes of combined posteroanterior (P-A) fusion and transforaminal thoracic interbody fusion (TTIF) in cases of thoracolumbar fracture-dislocation. SUMMARY OF BACKGROUND DATA...
journal_title:Spine
pub_type: 杂志文章,随机对照试验
doi:10.1097/BRS.0000000000000529
更新日期:2014-10-01 00:00:00
abstract:STUDY DESIGN:Cervical facet capsular strains were determined during bending and at failure in the human cadaver. OBJECTIVE:To determine the effect of an axial pretorque on facet capsular strains and estimate the risk for subcatastrophic capsular injury during normal bending motions. SUMMARY OF BACKGROUND DATA:Epidemi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200005150-00007
更新日期:2000-05-15 00:00:00
abstract:STUDY DESIGN:This study was designed to investigate prospectively a series of patients with syringomyelia-Chiari I complex operated on by a minimally invasive procedure. OBJECTIVE:The objective was to determine whether a relatively simple and low-risk osteo-dural decompression would obtain as good clinico-radiological...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199512000-00001
更新日期:1995-12-01 00:00:00
abstract:STUDY DESIGN:Systematic review, ambispective analysis of observational data. OBJECTIVE:To make recommendations as to whether or not urgent surgical decompression is ever indicated as the optimal treatment for enhancing neurologic recovery in a patient with acute central cord injury without fracture or instability. SU...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e3181f32a44
更新日期:2010-10-01 00:00:00
abstract:STUDY DESIGN:Validation study to define validity and reliability of an adapted and translated questionnaire. OBJECTIVE:Assessment of the concurrent validity and reliability of a Chinese version of SRS-22 outcome instrument. SUMMARY OF BACKGROUND DATA:No valid health-related quality of life (HRQL) outcome instrument e...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000261562.48888.e3
更新日期:2007-05-01 00:00:00
abstract:STUDY DESIGN:A case series of dual time-point F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of spinal cord sarcoidosis. OBJECTIVE:The aim of this study was to illustrate three cases of spinal sarcoidosis with occult presentation and subsequent identificati...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003122
更新日期:2019-11-01 00:00:00
abstract:STUDY DESIGN:We performed a retrospective study of spinal roentgenograms of a large cohort of patients suffering from osteogenesis imperfecta. OBJECTIVE:To determine the prevalence of vertebral pars defects (spondylolysis) in patients with osteogenesis imperfecta. SUMMARY OF BACKGROUND DATA:Patients suffering from os...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181a39646
更新日期:2009-06-01 00:00:00
abstract:STUDY DESIGN:Ten cadavers were dissected to describe the cutaneous branches of the dorsal rami nerves that should be identified and protected throughout the thoracoplasty procedure. OBJECTIVE:To identify the anatomic distribution of the cutaneous branches of the dorsal rami in the thoracic spine. SUMMARY OF BACKGROUN...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000253606.82387.96
更新日期:2007-02-01 00:00:00
abstract::The authors reviewed the results of the combined ventral derotation system (VDS) and Harrington operation in 34 selected patients with idiopathic scoliosis and kyphoscoliosis of double major curve pattern. The use of both VDS and Harrington instrumentation gives better correction and stabilization of the particular cu...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198704000-00009
更新日期:1987-04-01 00:00:00
abstract:STUDY DESIGN:Exploratory subgroup analysis in a randomized controlled trial (RCT). OBJECTIVE:To detect possible moderators in the effectiveness of a workplace intervention in a population of workers with sick leave due to sub acute nonspecific low back pain. SUMMARY OF BACKGROUND DATA:In a recently published RCT, a w...
journal_title:Spine
pub_type: 杂志文章,随机对照试验
doi:10.1097/BRS.0b013e3181a09631
更新日期:2009-05-20 00:00:00
abstract:STUDY DESIGN:A three-dimensional study of the thoracic pedicle (T1-T12) morphometry in Chinese patients with different body height, using reformatted computed tomography (CT). OBJECTIVE:To quantify the dimensions of the thoracic pedicles and to analyze the relationship between body height and thoracic pedicle paramete...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318210f063
更新日期:2011-11-15 00:00:00
abstract::A 27-year-old woman presented with nontraumatic atlantoaxial dislocation that required a C1-C2 fusion. A comprehensive investigation initially failed to reveal any evidence of infectious or rheumatologic disease and she remained well for 3 1/2 years, at which time a diagnosis of ankylosing spondylitis was established....
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199311000-00037
更新日期:1993-11-01 00:00:00