Local application of disc-related cytokines on spinal nerve roots.

Abstract:

STUDY DESIGN:To analyze the effects of tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma on cauda equina function and to define if any of these cytokines could induce nerve root dysfunction comparable with the situation with application of nucleus pulposus. SUMMARY OF BACKGROUND DATA:Proinflammatory cytokines derived from the intervertebral disc have been suggested to mediate the nucleus pulposus-induced nerve root injury following local application of nucleus pulposus. However, it is not known if such cytokines may induce similar injury if applied separately. METHODS:A total of 29 pigs were used. Nucleus pulposus was harvested from lumbar discs and applied to the sacrococcygeal cauda equina following laminectomy of the first coccygeal vertebra in seven pigs. Five pigs received 1.66 microg of tumor necrosis factor-alpha, five pigs received 0.85 microg of interleukin-1beta, and five pigs received 1.66 microg of interferon-gamma. Seven pigs received autologous fat for control. Nerve conduction velocity was studied by local electrical stimulation and recordings in the tail muscles 7 days after the application. RESULTS:Application of nucleus pulposus and fat induced similar effects as seen in previous studies, with normal nerve conduction velocity for fat and a significant reduction for nucleus pulposus. Application of both interleukin-1beta and IFN-gamma induced slight reductions of nerve conduction velocity compared with fat, but they were not statistically significant. Tumor necrosis factor-alpha, however, induced a reduction of the velocity that was even more pronounced than for nucleus pulposus. CONCLUSION:Based on previous observations and the data of the present study, one may conclude that tumor necrosis factor-alpha from nucleus pulposus cells seems to be intimately involved with the basic pathophysiologic events leading to both nerve root dysfunction and pain after local, epidural application of nucleus pulposus. One may therefore also suspect that pharmacologic inhibition of tumor necrosis factor-alpha may at least theoretically be considered in the clinical situation with disc herniation and sciatica.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Aoki Y,Rydevik B,Kikuchi S,Olmarker K

doi

10.1097/00007632-200208010-00004

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

1614-7

issue

15

eissn

0362-2436

issn

1528-1159

pii

00007632-200208010-00004

journal_volume

27

pub_type

杂志文章

相关文献

SPINE文献大全
  • A vertebral fracture in childhood is not a risk factor for disc degeneration but for Schmorl's nodes: a mean 40-year observational study.

    abstract:STUDY DESIGN:Observational cohort study. OBJECTIVE:To evaluate by MRI whether a vertebral fracture during childhood is a risk factor for degeneration of adjacent discs. SUMMARY OF BACKGROUND DATA:Several studies infer that trauma is a major cause of disc degeneration. Only 1 study has by magnetic resonance imaging (M...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181573d6a

    authors: Möller A,Maly P,Besjakov J,Hasserius R,Ohlin A,Karlsson MK

    更新日期:2007-10-15 00:00:00

  • Cost Analysis of Magnet-driven Growing Rods for Early-onset Scoliosis at 5 Years.

    abstract:STUDY DESIGN:Prospective case series of nine children with early-onset scoliosis (EOS) treated by a single surgeon with a novel implant, the magnet-driven growing rod (MdGR) in a publicly funded health care service accounting for "payer costs" (PC) incurred. OBJECTIVE:The aim of this study was to compare the cost-effe...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002738

    authors: Harshavardhana NS,Noordeen MHH,Dormans JP

    更新日期:2019-01-01 00:00:00

  • Anterior extension of the thoracic vertebral bodies in Scheuermann's kyphosis. An anatomic study.

    abstract::Changes consistent with Scheuermann's kyphosis were noted in 103 specimens (7.4%) of a sample of 1,384 thoracic spines in the Hamann-Todd collection of human skeletons. In 94% of the affected vertebrae, a distinct anterior elongation of the vertebral centrum was present. This anterior extension was composed of mature ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198907000-00011

    authors: Digiovanni BF,Scoles PV,Latimer BM

    更新日期:1989-07-01 00:00:00

  • Lumbar spine fusion for chronic low back pain due to degenerative disc disease: a systematic review.

    abstract:STUDY DESIGN:Systematic literature review. OBJECTIVE:To categorize published evidence systematically for lumbar fusion for chronic low back pain (LBP) in order to provide an updated and comprehensive analysis of the clinical outcomes. SUMMARY OF BACKGROUND DATA:Despite a large number of publications of outcomes of sp...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3182877f11

    authors: Phillips FM,Slosar PJ,Youssef JA,Andersson G,Papatheofanis F

    更新日期:2013-04-01 00:00:00

  • Anatomic studies of the circulation in the region of the vertebral end-plate in adult Greyhound dogs.

    abstract::In order to study the detailed arrangements of vascular terminations in the region of the vertebral end-plate in adult dogs, infusions of Japanese ink mixed with a suspension of barium sulfate were used to produce filling of the vascular terminations at the vertebral end-plates. Radiographs were made of the decalcifie...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198410000-00009

    authors: Crock HV,Goldwasser M

    更新日期:1984-10-01 00:00:00

  • Spine update. Degenerative lumbar spondylolisthesis.

    abstract::Degenerative lumbar spondylolisthesis associated with spinal stenosis is a common condition of the aging spine. This article presents a detailed description of the pathophysiology, clinical presentation, and nonoperative and operative intervention of this condition. ...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-199505000-00018

    authors: Herkowitz HN

    更新日期:1995-05-01 00:00:00

  • A Whole Exome Study Identifies Novel Candidate Genes for Vertebral Bone Marrow Signal Changes (Modic Changes).

    abstract:STUDY DESIGN:A family-based study. OBJECTIVE:The aim of this study was to identify rare genetic factors predisposing to Modic changes (MCs). SUMMARY OF BACKGROUND DATA:Lumbar disc degeneration (LDD) is one of the contributing factors behind low back pain (LBP). Lumbar MC visualized as bone marrow signal intensity cha...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002049

    authors: Kraatari M,Skarp S,Niinimäki J,Karppinen J,Männikkö M

    更新日期:2017-08-15 00:00:00

  • Surgery for lumbar spinal stenosis. Attempted meta-analysis of the literature.

    abstract::A meta-analysis was undertaken to determine the effects of surgery for lumbar spinal stenosis on pain and disability. Seventy-four journal articles met inclusion criteria and were independently reviewed by two readers. On average, 64% of patients treated surgically for lumbar spinal stenosis were reported to have good...

    journal_title:Spine

    pub_type: 杂志文章,meta分析

    doi:10.1097/00007632-199201000-00001

    authors: Turner JA,Ersek M,Herron L,Deyo R

    更新日期:1992-01-01 00:00:00

  • Finite element analysis of the effects of pedicle screw fixation nut loosening on lumbar interbody fusion based on the elasto-plateau plasticity of bone characteristics.

    abstract:STUDY DESIGN:Cylindrical cages and pedicle screw fixation (PSF) have been used for the setting of a lumbar interbody fusion. OBJECTIVE:To investigate the effects of PSF-nut loosening on lumbar interbody fusion based on the elasto-plateau plasticity of bone characteristics. SUMMARY OF BACKGROUND DATA:The stress-strain...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181b6258a

    authors: Kim Y,Kim TW

    更新日期:2010-03-15 00:00:00

  • Congenital absence of lumbar facets as a cause of lower-back pain.

    abstract::Unilateral arch hypertrophy secondary to congenital absence of lumbar articular facets is a rare condition of still undetermined etiology. Most symptomatic cases had a history of mild trauma. Radiologic criteria using plain films and CAT scan are available to make the diagnosis of unilateral arch hypertrophy and the s...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198601000-00024

    authors: Segal D,Franchi AV

    更新日期:1986-01-01 00:00:00

  • Comparison of 6-year Follow-up Result of Hybrid Surgery and Anterior Cervical Discectomy and Fusion for the Treatment of Contiguous Two-segment Cervical Degenerative Disc Diseases.

    abstract:STUDY DESIGN:A retrospective study. OBJECTIVE:To compare the mid-term outcomes of hybrid surgery (HS) and anterior cervical discectomy and fusion (ACDF) for the treatment of contiguous two-segment cervical degenerative disc diseases. SUMMARY OF BACKGROUND DATA:HS has become one of the most controversial subjects in s...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002639

    authors: Xiong Y,Xu L,Yu X,Yang Y,Zhao D,Hu Z,Li C,Zhao H,Duan L,Zhang B,Chen S,Liu T

    更新日期:2018-10-15 00:00:00

  • Disc pressure measurements.

    abstract::By measurement of intradiscal pressure in vitro, the hydrostatic properties of the nucleus pulposus of normal lumbar intervertebral disc were proven. The hydrodynamic properties seem to exist also in the somewhat degenerated disc, but not in the more severely deranged ones. Intravitally-performed measurements of disc ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198101000-00020

    authors: Nachemson AL

    更新日期:1981-01-01 00:00:00

  • In situ contact analysis of the prosthesis components of Prodisc-L in lumbar spine following total disc replacement.

    abstract:STUDY DESIGN:A three-dimensional, nonlinear finite element analysis was performed to predict the in situ contact interaction of prosthesis components of the Prodisc-L in a multisegmental lumbar model following total disc replacement (TDR). OBJECTIVE:Efforts were made to investigate how the TDR implant contact characte...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181ae23d1

    authors: Chen WM,Park C,Lee K,Lee S

    更新日期:2009-09-15 00:00:00

  • Complications of spinal fusion for scheuermann kyphosis: a report of the scoliosis research society morbidity and mortality committee.

    abstract:STUDY DESIGN:Retrospective review of a prospectively collected, multicentered database from the Scoliosis Research Society. OBJECTIVES:To evaluate incidences of complications in a series of spinal fusions for Scheuermann kyphosis (SK) and to assess whether the incidence of complications is associated with patient age ...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0b013e3181c47f0f

    authors: Coe JD,Smith JS,Berven S,Arlet V,Donaldson W,Hanson D,Mudiyam R,Perra J,Owen J,Marks MC,Shaffrey CI

    更新日期:2010-01-01 00:00:00

  • Beliefs and expectations for recovery, coping, and depression in whiplash-associated disorders: lessening the transition to chronicity.

    abstract:STUDY DESIGN:Literature review and discussion. OBJECTIVE:To discuss the role played by beliefs, expectations, coping, and depression in the transition to chronicity in whiplash-associated disorders (WAD), and to discuss their clinical and research implications. SUMMARY OF BACKGROUND DATA:Psychological factors are imp...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e31823881a4

    authors: Carroll LJ

    更新日期:2011-12-01 00:00:00

  • Results of a longer than 10-year follow-Up of patients with rheumatoid arthritis treated by occipitocervical fusion.

    abstract:STUDY DESIGN:Evaluation of results a longer than 10-year follow-up of patients with upper cervical lesions due to rheumatoid arthritis who underwent occipitocervical fusion. OBJECTIVE:To determine the final outcome of patients with upper cervical lesions due to rheumatoid arthritis treated by occipitocervical fusion. ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200007150-00002

    authors: Matsunaga S,Ijiri K,Koga H

    更新日期:2000-07-15 00:00:00

  • Repair of vertebral artery injury during anterior cervical decompression.

    abstract:METHODS:Vertebral artery injury is a rarely described complication of anterior cervical decompression. The authors performed a retrospective review of their operative database for the purposes of defining the optimal management of this complication and its avoidance. RESULTS:Four of 1,215 (0.3%) patients undergoing an...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199411001-00010

    authors: Golfinos JG,Dickman CA,Zabramski JM,Sonntag VK,Spetzler RF

    更新日期:1994-11-15 00:00:00

  • Spinal stabilization of vertebral column tumors.

    abstract::An analysis of indications, techniques, results of stabilization and decompression of 100 consecutive spinal tumour cases was carried out. Localized metastatic disease is best operated anteriorly. Primary malignancies are best treated with en bloc resection. Pain relief in metastatic disease is achieved by rigid stabi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198803000-00006

    authors: Kostuik JP,Errico TJ,Gleason TF,Errico CC

    更新日期:1988-03-01 00:00:00

  • A randomized clinical trial of manipulative therapy and interferential therapy for acute low back pain.

    abstract:STUDY DESIGN:A multicenter assessor-blinded randomized clinical trial was conducted. OBJECTIVES:To investigate the difference in effectiveness of manipulative therapy and interferential therapy for patients with acute low back pain when used as sole treatments and in combination. SUMMARY OF BACKGROUND DATA:Both manip...

    journal_title:Spine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.brs.0000142234.15437.da

    authors: Hurley DA,McDonough SM,Dempster M,Moore AP,Baxter GD

    更新日期:2004-10-15 00:00:00

  • Effects of subject position on measurements of flexion, extension, and lateral flexion of the spine.

    abstract::Effects of subject positions on range and repeatability of thoracic and lumbar forward flexion, extension, and lateral flexion were studied. Inclinometric methods were used, and 27 subjects were measured by two trained testers. No great differences in repeatability and range of movements were found between measurement...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199109000-00016

    authors: Mellin G,Kiiski R,Weckström A

    更新日期:1991-09-01 00:00:00

  • A ligamentum flavum-preserving approach to the lumbar spinal canal.

    abstract:STUDY DESIGN:This is a retrospective study of a consecutive series of patients undergoing spinal decompression or disc enucleation with preservation of the ligamentum flavum. MacNab criteria and Prolo scoring was used to assess them pre- and after surgery. OBJECTIVES:The aim of the study was to assess the incidence of...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000085100.10349.15

    authors: Askar Z,Wardlaw D,Choudhary S,Rege A

    更新日期:2003-10-01 00:00:00

  • Fat embolism and acute hypotension during vertebroplasty: an experimental study in sheep.

    abstract:STUDY DESIGN:An experimental study of cardiovascular complications that arise during vertebroplasty was conducted. OBJECTIVE:To investigate the sequential occurrence of fat embolism and hypotension during vertebroplasty. SUMMARY OF BACKGROUND DATA:Vertebroplasty, the augmentation of vertebrae with polymethylmethacryl...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200203010-00005

    authors: Aebli N,Krebs J,Davis G,Walton M,Williams MJ,Theis JC

    更新日期:2002-03-01 00:00:00

  • Metaplastic proliferative fibrocartilage as an alternative concept to herniated intervertebral disc.

    abstract::It is hypothesized on the basis of experimental intervertebral disc degeneration that herniated disc is actually newly synthesized proliferative metaplastic fibrocartilage and not herniation of pre-existing disc tissue, particularly that of the nucleus pulposus. Human material in selected surgical tissues was examined...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198809000-00014

    authors: Lipson SJ

    更新日期:1988-09-01 00:00:00

  • Antimicrobial Effect of Polymer-Based Silver Nanoparticle Coated Pedicle Screws: Experimental Research on Biofilm Inhibition in Rabbits.

    abstract:STUDY DESIGN:Antimicrobial effect of a novel silver-impregnated pedicle screw in rabbits. OBJECTIVE:A novel spine implant model was designed to study the antimicrobial effect of a modified Titanium (Ti) pedicle screws with methicillin-resistant Staphylococcus aureus (MRSA) in multiple surgical sites in the lumbar spin...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001223

    authors: Hazer DB,Sakar M,Dere Y,Altinkanat G,Ziyal MI,Hazer B

    更新日期:2016-03-01 00:00:00

  • Cultural adaptation, reliability, and validity of neck disability index in Indian rural population: a Marathi version study.

    abstract:STUDY DESIGN:A cross-sectional study to develop a cultural adaptation of the Marathi-neck disability index (NDI) and to investigate its validity and reliability. OBJECTIVE:To conduct a study concerning the cultural adaptation of the NDI and investigate the validity and reliability of its Marathi version in patients wi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000681

    authors: Joseph SD,Bellare B,Vernon H

    更新日期:2015-01-15 00:00:00

  • The long-term follow-up of surgical treatment for cervical myelopathy with severe nape and upper arm pain caused by the anomalous vertebral artery: case report.

    abstract:STUDY DESIGN:A case of cervical myelopathy with a severe nape and upper arm pain caused by anomalous bilateral vertebral arteries is reported. OBJECTIVE:To report over six and a half years results of a microsurgical decompression for high cervical myelopathy with a severe pain of nape and upper arm resulting from spin...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31817c6c17

    authors: Takei H,Sagae M,Chiba K,Ogino T

    更新日期:2008-08-01 00:00:00

  • The evidence for intraoperative neurophysiological monitoring in spine surgery: does it make a difference?

    abstract:OBJECTIVE:The objective of this article was to undertake a systematic review of the literature to determine whether IOM is able to sensitively and specifically detect intraoperative neurologic injury during spine surgery and to assess whether IOM results in improved outcomes for patients during these procedures. SUMMA...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3181d8338e

    authors: Fehlings MG,Brodke DS,Norvell DC,Dettori JR

    更新日期:2010-04-20 00:00:00

  • Obesity is associated with reduced disc height in the lumbar spine but not at the lumbosacral junction.

    abstract:STUDY DESIGN:Cross-sectional, community-based study. OBJECTIVE:To investigate the relationships between obesity, disc height, and low back pain in the lumbosacral spine. SUMMARY OF BACKGROUND DATA:Although obesity is a recognized risk factor for low back pain, our understanding of the mechanisms for this is limited. ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000411

    authors: Urquhart DM,Kurniadi I,Triangto K,Wang Y,Wluka AE,OʼSullivan R,Jones G,Cicuttini FM

    更新日期:2014-07-15 00:00:00

  • A system for surgical staging and management of spine tumors. A clinical outcome study of giant cell tumors of the spine.

    abstract:STUDY DESIGN:This study developed and independently applied a spine tumor classification system, referred to as the Weinstein-Boriani-Biagini system, in a retrospective analysis of a series of patients with spinal giant cell tumors from three institutions. OBJECTIVE:To evaluate factors of potential prognostic signific...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199708010-00018

    authors: Hart RA,Boriani S,Biagini R,Currier B,Weinstein JN

    更新日期:1997-08-01 00:00:00

  • The Effect of Substance P on an Intervertebral Disc Rat Organ Culture Model.

    abstract:STUDY DESIGN:Laboratory study. OBJECTIVE:Evaluate the effect of substance P (SP) on an intervertebral disc rat organ culture model. SUMMARY OF BACKGROUND DATA:Monolayer cell experiments have demonstrated that exposure intervertebral disc tissue cells to SP leads to upregulation in inflammatory cytokine expression; ho...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001676

    authors: Koerner JD,Markova DZ,Schroeder GD,Rihn JA,Hilibrand AS,Vaccaro AR,Anderson DG,Kepler CK

    更新日期:2016-12-15 00:00:00