Abstract:
STUDY DESIGN:Antimicrobial effect of a novel silver-impregnated pedicle screw in rabbits. OBJECTIVE:A novel spine implant model was designed to study the antimicrobial effect of a modified Titanium (Ti) pedicle screws with methicillin-resistant Staphylococcus aureus (MRSA) in multiple surgical sites in the lumbar spine of a rabbit. SUMMARY OF BACKGROUND DATA:Infection in spinal implant is of great concern. Anti-infection strategies must be tested in relevant animal models that will lead to appropriate clinical studies. METHODS:Fourteen New Zealand white rabbits were divided into 2 groups: group 1: infected unmodified Ti screw group (n = 6), and group 2: infected polyethylene glycol grafted, polypropylene-based silver nanoparticle (PP-g-PEG-Ag) covered Ti screw group (n = 6), and 2 rabbits as sterile (sham-operated and control) group. In all groups, left L4-right L6 vertebra levels were exposed and screws were drilled to transverse processes after contamination of burr holes and surrounding tissue with 0.1 mL of 10 colony forming units (CFU) MRSA solutions in groups 1 and 2. After 21 days, samples were collected and infection was analyzed via light and scanning electron microscopy and culturing. Silver nanoparticles (Ag-NP) on the screws and tissues were assayed pre and postoperatively. RESULTS:The bacterial colony count for modified-Ti screw group was lower than for unmodified Ti screw (17.2 versus 200 x 10(3) CFU/mL, P = 0.029) with less biofilm formation. There was no difference in duration of surgery among groups and within the surgical sites. Ag-NPs were detected on the screw surface postoperatively. CONCLUSION:This novel experimental design of implantation in rabbits is easy to apply and resembles human stabilization technique. Modified Ti screws were shown to have antimicrobial effect especially inhibiting the biofilm formation. This anchored Ag NPs that remained after 21st day of implantation shows that it is resistant to tapping forces of the screw.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Hazer DB,Sakar M,Dere Y,Altinkanat G,Ziyal MI,Hazer Bdoi
10.1097/BRS.0000000000001223subject
Has Abstractpub_date
2016-03-01 00:00:00pages
E323-9issue
6eissn
0362-2436issn
1528-1159journal_volume
41pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:To identify mesenchymal stromal cells (MSC) from degenerate human nucleus pulposus (NP) and compare them with bone marrow (BM) MSC. OBJECTIVE:To test whether MSC obtained from NP and BM from the same subjects share similar biologic characteristics. SUMMARY OF BACKGROUND DATA:Recent studies have proposed ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181cb8828
更新日期:2010-12-15 00:00:00
abstract::A new type of impactor was developed to decompress the anterior aspect of the vertebral body. These instruments are particularly useful for cases of burst fracture. ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199308000-00018
更新日期:1993-08-01 00:00:00
abstract::Fifteen cervical spines from cadavers were used to compare the rotational and translational stability of the Brooks fusion, a fusion construct using Halifax interlaminar clamps, and the Gallie fusion. The Brooks and Halifax clamp constructs exhibited significantly greater rotational and translational stiffness than th...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199302000-00001
更新日期:1993-02-01 00:00:00
abstract:STUDY DESIGN:Case report and long-term follow-up. OBJECTIVES:To answer the question of whether the operation performed was worthwhile and lasting. SUMMARY OF BACKGROUND DATA:Congenital kyphosis due to defects of vertebral body formation has a high incidence of paraplegia if not surgically stabilized. Traditional post...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199709150-00018
更新日期:1997-09-15 00:00:00
abstract:STUDY DESIGN:Prospective, double-blinded, randomized controlled study. OBJECTIVE:To determine whether the use of 2 doses of tranexamic acid (TXA) can reduce perioperative blood loss and blood transfusions in low-risk adult patients undergoing complex laminectomy. SUMMARY OF BACKGROUND DATA:Complex laminectomy (multil...
journal_title:Spine
pub_type: 杂志文章,随机对照试验
doi:10.1097/BRS.0000000000001063
更新日期:2015-12-01 00:00:00
abstract:STUDY DESIGN:An intramuscular electromyographic study was performed on trunk rotations during sitting and standing. OBJECTIVE:The aim was to provide new information on activation levels for deep trunk muscles in various unresisted and resisted trunk rotations. SUMMARY AND BACKGROUND DATA:Frequent daily trunk twisting...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/00007632-200203150-00014
更新日期:2002-03-15 00:00:00
abstract:STUDY DESIGN:A prospective cohort study. OBJECTIVE:To evaluate the effects of epidural steroid injections (ESIs) on blood glucose levels in patients with diabetes mellitus. SUMMARY OF BACKGROUND DATA:ESIs are commonly used in the treatment of multiple spinal disorders. Corticosteroid injections have been evaluated in...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/BRS.0b013e31821fd21f
更新日期:2012-01-01 00:00:00
abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVE:To assess the inter- and intraobserver reliability of thoracic, spino-pelvic, and rod lengthening measurements made on biplanar spinal stereoradiography (EOS imaging) in children treated with magnetically controlled growing rod (MCGR). SUMMARY OF BACKGROUND DATA:MCGR trea...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002671
更新日期:2018-11-15 00:00:00
abstract:STUDY DESIGN:This study determined bone mineral density (BMD) of cervical, thoracic, and lumbar vertebrae in healthy asymptomatic human subjects. OBJECTIVES:To test the hypothesis that BMD of neck vertebrae (C2-C7) is equivalent to BMD of lumbar vertebrae (L2-L4). SUMMARY OF BACKGROUND DATA:BMD of lumbar vertebrae is...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000192684.12046.93
更新日期:2006-01-01 00:00:00
abstract::Giovanni Alfonso Borelli is often described as the father of biomechanics. He was born in Naples in 1608. His De Motu Animalium, published in 1680, extended to biology the rigorous analytical methods developed by Galileo in the field of mechanics. Borelli calculated the forces required for equilibrium in various joint...
journal_title:Spine
pub_type: 传,历史文章,杂志文章
doi:10.1097/01.brs.0000182314.49515.d8
更新日期:2005-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of spinal exostoses treated at our institution and literature review. OBJECTIVES:Review of 12 cases of spinal exostoses treated at our institution compared with 165 cases of spinal exostoses reported in the literature. SUMMARY OF BACKGROUND DATA:Spinal exostoses are uncommon. Most re...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/01.brs.0000157476.16579.a2
更新日期:2005-04-01 00:00:00
abstract:STUDY DESIGN:The position of a needle tip displayed on a navigation system after transpedicular introduction into a vertebral body is compared with the real position of the needle tip when using a direct navigation coupling between a three-dimensional rotational X-ray (3DRX) system and a navigation system. OBJECTIVES:...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000218580.54036.1b
更新日期:2006-05-20 00:00:00
abstract:STUDY DESIGN:Three transaxial slices, dividing each disc into four layers of equal thickness, were made in each of 19 T12-L1 discs. Naked-eye and stereoscopic examination was used to record abnormalities of the T12 (superior) surface of the upper slice, opposing surfaces of the central slice, and the L1 (inferior) surf...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199711150-00012
更新日期:1997-11-15 00:00:00
abstract:STUDY DESIGN:A three-dimensional finite element investigation. OBJECTIVES:To create a three-dimensional finite element model of the cervical spinal cord enlargement and to simulate a hyperextension injury of the cervical cord. SUMMARY OF BACKGROUND DATA:Experimental studies are difficult to simulate the complex mecha...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31819e2af1
更新日期:2009-05-15 00:00:00
abstract::A case of thoracic chordoma successfully treated with surgical excision is reported and described. Thoracic chordomata presenting as posterior superior mediastinal tumors occur infrequently and may be highly malignant lesions. Early radical surgery through thoracotomy provide the best hope of cure, and radiation offer...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198310000-00016
更新日期:1983-10-01 00:00:00
abstract::This report concerns 15 adults (nine men and six women) who experienced lumbar and sciatic pain associated with an unusual defect of the edges of the vertebral bodies together with a small bony ridge protruding into the spinal canal. This lesion was well demonstrated by computed tomography and easily differentiated fr...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199212000-00011
更新日期:1992-12-01 00:00:00
abstract:STUDY DESIGN:In vivo animal study. OBJECTIVES:To describe a new porcine disc degeneration model, and to analyze disc remodeling and degeneration after nucleotomy with special view to the different nucleus pulposus (NP) cell types. SUMMARY OF BACKGROUND DATA:Thus far, predominantly smaller animals were used for disc d...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181b723c9
更新日期:2009-12-01 00:00:00
abstract:STUDY DESIGN:A 2-year follow-up prospective randomized electrophysiologic and clinical study of patients with spondylotic cervical myelopathy. OBJECTIVE:To assess the value of somatosensory- and motor-evoked potentials in the evaluation and prediction of the effect of therapy. SUMMARY OF BACKGROUND DATA:Previous stud...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-199908010-00014
更新日期:1999-08-01 00:00:00
abstract:STUDY DESIGN:A patient with a medical history of Sweet's Syndrome, an acute neutrophilic dermatosis, was seen at the authors' institution for cervical pain. After undergoing a thorough history-taking and physical examination and after experiencing no relief with conservative therapy, the patient underwent cervical spin...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199808010-00019
更新日期:1998-08-01 00:00:00
abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The aims of this study were to (1) compare patient and procedure-specific characteristics among those who had short versus long hospital stays and (2) identify independent risk factors that may correlate with extended length of hospital stay (LOS) in patients with ado...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002919
更新日期:2019-05-15 00:00:00
abstract:STUDY DESIGN:A retrospective, follow-up cohort study. OBJECTIVE:To evaluate the 25-year (or longer) outcome of discectomy for lumbar disc herniation by validated instruments. SUMMARY OF BACKGROUND DATA:A comprehensive patient-oriented evaluation should include measurements of pain and disability along with a reliable...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000240726.26096.be
更新日期:2006-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of prospectively-collected, multicenter adult spinal deformity (ASD) database. OBJECTIVE:The aim of this study was to evaluate the rate of patients who accrue catastrophic cost (CC) with ASD surgery utilizing direct, actual costs, and determine the feasibility of predicting these outl...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000003242
更新日期:2020-03-01 00:00:00
abstract::Delayed CT Myelography (CTM) demonstrated intramedullary cavities in 18 patients, most of which appeared on the 6-hour scan. The attenuation values of the normal spinal cord increased progressively with time, and recorded a peak at 6 hours. The CT numbers of the gray matter of metrizamide were significantly high, as c...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198807000-00005
更新日期:1988-07-01 00:00:00
abstract:STUDY DESIGN:Forty patients were enrolled in 2 FDA-approved pilot Investigational Device Exemption (IDE) studies using Cortoss for the treatment of vertebral compression fractures (VCF). Twenty patients were treated at 3 centers, using vertebroplasty (VP) and 20 patients were treated at 5 centers, using kyphoplasty (KP...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e3181dcda75
更新日期:2010-09-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of prospectively collected data. OBJECTIVE:The objective of this study was to evaluate outcomes between patients receiving LMWH vs. UH in a retrospective cohort of patients with spine trauma. SUMMARY OF BACKGROUND DATA:Although multiple clinical trials have been conducted, current gu...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003664
更新日期:2020-08-26 00:00:00
abstract:STUDY DESIGN:Lumbar spine kinematic response to a 1.0 body weight compressive load was measured in vivo by comparison of relaxed and loaded magnetic resonance image sets in the sagittal plane. OBJECTIVES:To identify and measure acute response mechanisms of the lumbar spine during compression loading. SUMMARY OF BACKG...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200109150-00004
更新日期:2001-09-15 00:00:00
abstract::Does infant malnutrition produce smaller adult spinal canals? Lumbar and thoracic vertebrae (n X 1073), from a prehistoric American Indian population (15-55 yrs of age), were measured for anteroposterior (AP) and transverse (TR) vertebral canal sizes, nerve root tunnel (intervertebral foramen) widths (NRT), vertebral ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198503000-00012
更新日期:1985-03-01 00:00:00
abstract:STUDY DESIGN:Experimental dog model of acute spinal cord injury. OBJECTIVE:To compare the relative value of methylprednisolone, surgical decompression, or both for the treatment of traumatic spinal cord injury. SUMMARY OF BACKGROUND DATA:Acute spinal cord injury results from both primary damage to the spinal cord at ...
journal_title:Spine
pub_type: 杂志文章,随机对照试验
doi:10.1097/BRS.0b013e31818786db
更新日期:2008-10-01 00:00:00
abstract:STUDY DESIGN:Load sharing in stabilized spinal segments was evaluated using sequential injury and stabilization with a posterior instrumentation system under an in vitro flexibility protocol. OBJECTIVE:To analyze the partitioning of applied loads between anatomic and implanted structures of lumbar functional spinal un...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200001150-00006
更新日期:2000-01-15 00:00:00
abstract:STUDY DESIGN:Retrospective database review OBJECTIVE.: The aim of this study was to analyze the implications of solid organ transplant (SOT) on postoperative outcomes following elective one or two-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA:Although SOTs have been associated with i...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003230
更新日期:2020-02-01 00:00:00