Abstract:
BACKGROUND:In the past few decades, very little research has been carried out to modify implant surfaces to improve osteointegration through the regulation of immune cells. PURPOSE:The aim of this study is to investigate whether the poly(dopamine) (pDA)-assisted immobilization of IL4 on titanium surfaces could modulate the inflammatory profile of macrophages in vitro and search for the possibility of enhancing implant integration in this way. MATERIAL AND METHODS:The surface composition, topography, and roughness of SLA, SLA-pDA, and SLA-pDA-IL4 discs were examined by scanning electron microscope (SEM) and energy dispersive spectrometer (EDS). Then the releasing profile of the SLA-pDA-IL4 implants was recorded for 1 week and the bioactivity of released IL4 was investigated by ELISA. Then macrophage polarization was investigated via three methods including: (a) surface marker via immunofluorescence; (b) mRNA levels of M1 and M2 polarization markers via real-time PCR, and (c) cytokine release via ELISA. RESULTS:SEM and EDS revealed that pDA and IL4 were coated successfully on SLA surfaces. The ELISA results showed that IL4 remained its bioactivity on SLA surface and were immobilized on the SLA surface. The immobilization of IL4 through pDA has no significant influence on the attachment, morphology, and proliferation of macrophages, while it increased the M2/M1 proportion in human macrophages revealed by immunofluorescence. The real-time PCR and ELISA results demonstrated that SLA-pDA-IL4 surface reduced the pro-inflammatory profile compared with SLA-pDA and SLA surfaces. CONCLUSIONS:The SLA-pDA-IL4 surfaces described here is able to activate adherent macrophages into M2 phenotype and reduce the release of pro-inflammatory cytokines. Immobilization of IL4 via pDA is convenient and effective, thus providing an applicable way to control macrophage behavior upon implant insertion and is anticipated to accelerating further bone integration.
journal_name
Clin Implant Dent Relat Resjournal_title
Clinical implant dentistry and related researchauthors
Wang Y,Qi H,Miron RJ,Zhang Ydoi
10.1111/cid.12819subject
Has Abstractpub_date
2019-10-01 00:00:00pages
977-986issue
5eissn
1523-0899issn
1708-8208journal_volume
21pub_type
杂志文章abstract:OBJECTIVE:To evaluate the histological and microtomographic response of peri-implant bone tissue around titanium implants with different surface treatments, placed in bone defects filled or not filled with bone substitute materials. MATERIALS AND METHODS:Thirty rabbits were divided into two groups according to the imp...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12880
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Data on risk factors and complications after long-term implant treatment is limited. The aims were to evaluate the role of various fixation modes and to analyze complications and risks that affect long-term use of implant-supported partial fixed dental prostheses. MATERIALS AND METHODS:Fifty partially edent...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12587
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Evaluation of the clinical conditions following computer guided treatment planning and flapless surgery is still limited. OBJECTIVES:The objective was to evaluate the soft tissue conditions and marginal bone changes after 1 year of function around immediately loaded implants inserted in edentate jaws follow...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2009.00243.x
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Mesenchymal stem cell (MSC) treatment in conjunction with bone graft materials or space filler can be an alternative to autogenous bone grafts in the treatment of peri-implant bone defects. PURPOSE:To evaluate the success of bone regeneration capacity of adipose-derived and bone marrow-derived MSCs for the ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12378
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:There are no studies that have evaluated the correlation between self-rated pain, peri-implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TN...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12866
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:It is hypothesized that peri-implant conditions are worse with increasing severity of obesity, because systemic low-grade inflammatory marker (C-reactive protein [CRP]) is higher in severe form of obese individuals. PURPOSE:The aim of the cross-sectional retrospective study was to compare clinical and radio...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12556
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The use of computer software and stereolithography for dental implant therapy has significantly increased during the last few years. The aim of this study was to evaluate and compare the mean accuracy and maximum deviations values of dental implant placement using two stereolithographic (SLA) guide systems. ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00369.x
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Although small perforation of the maxillary sinus schneiderian membrane is a well-documented complication during lateral sinus floor elevation (LSFE), complete perforations larger than 10 mm often result in discontinuation of surgery. Reports on reentry LSFE and its long-term outcomes are sparse. PURPOSE:To...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12932
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:One of the objectives of postoperative radiographic examinations of implants is to evaluate the marginal bone height and its changes over time. PURPOSE:The purpose of this study was to assess the influence of digital image processing on measurements of the marginal bone level around implants. MATERIAL AND ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2000.tb00102.x
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:The aim of this preclinical study was to analyze and compare different grafting techniques with respect to volume stability after wound closure. MATERIALS AND METHODS:Four different grafting techniques were evaluated in vitro for volume stability in a one-wall horizontal defect configuration. Group 1: guide...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12728
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Comparisons between different techniques measuring fit of implant-supported frameworks are few. PURPOSE:The purpose of this study was to compare data on precision of fit from two highly accurate measuring techniques and, also, to compare results using software programs for fit assessments considering both a...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00416.x
更新日期:2012-05-01 00:00:00
abstract:UNLABELLED:Osteonecrosis of the jaw (ONJ) is a severe complication of bisphosphonate treatment. PURPOSE:A detailed characterization of sampled peri-necrotic jawbone from bisphosphonate-treated patients was performed at tissue and cellular level (histological analyses and gene expression). MATERIALS AND METHODS:Alveol...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12307
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Discrimination between ongoing and solved research questions may help to distinguish established dogmas from evidence-based implant dentistry. PURPOSE:The purpose of this study was to investigate topics of interest in the field of oral implant science and evolving thematic trends in clinical studies during ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,评审
doi:10.1111/cid.12371
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Improvements of soft tissue to the abutment surface results in more stable peri-implant conditions, however, few human histological studies have compared soft tissue responses around different abutment materials. PURPOSE:To describe the peri-implant tissue around 3 abutment materials; titanium, zirconia, an...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,随机对照试验
doi:10.1111/cid.12562
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Implant surface topography influences the bone response after implantation. However, the importance of surface orientation is not known. PURPOSE:The aim of this study was to investigate the bone tissue response and the stability of titanium implants prepared with isotropic and anisotropic surfaces of simila...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2005.tb00042.x
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess, for implant placement in the posterior maxilla, the accuracy of linear measurements provided by cone beam computed tomography (CBCT) using an image intensifier tube and television (TV) chain as an X-ray detector despite a loss of contrast resolution. The NewTom 9000 (Quantit...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00083.x
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:A recent in vivo study has shown considerable contamination of internal implant and suprastructure components with great biodiversity, indicating bacterial leakage along the implant-abutment interface, abutment-prosthesis interface, and restorative margins. The goal of the present study was to compare microbiol...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2009.00220.x
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The effects of the locations of dental implants on treatment outcomes, as evaluated by oral health-related quality of life (OHRQoL) assessment, remain controversial. PURPOSE:To investigate the association between the locations of dental implants and changes in OHRQoL. MATERIALS AND METHODS:Sixty-eight subj...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12497
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:One possible complication of implant surgery in the posterior maxilla is the displacement of implants into the maxillary sinus. PURPOSE:To report on clinical and radiological findings and on biological, surgical, and biomechanical considerations in cases of implant displacement. MATERIALS AND METHODS:This ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12244
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:Posterior maxillary tilted implants are gaining prevalence as an alternative to sinus grafts supporting fixed maxillary restorations. This paper reports long-term results after loading using this technique. MATERIALS AND METHODS:Consecutive patients presenting for either routine hygiene maintenance or unplanne...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12433
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:There is limited knowledge on the relationship between implant failures and patient age at implant surgery. PURPOSE:To further analyze and report long-term data on previously presented significant associations between implant failures and age at surgery in patients receiving treatment in the edentulous jaw....
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12753
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Bovine-derived grafting materials are frequently used in a variety of bone augmentation techniques. The aim of this paper is to assess the unique safety issue of bovine-derived grafting materials that is rarely addressed in dental literature: risk of bovine spongiform encephalopathy (BSE). METHODS:The valid...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12391
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To investigate the effectiveness of adding leukocyte and platelet-rich fibrin (L-PRF) to deproteinized bovine bone mineral (DBBM) for early implant placement after maxillary sinus augmentation. MATERIALS AND METHODS:Twelve patients requiring two-stage bilateral maxillary sinus augmentation were enrolled to the...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,随机对照试验
doi:10.1111/cid.12713
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare endodontic and implant treatments and to evaluate their predictability over an 8-year period on the basis of an analysis of survival data and a retrospective clinical study. MATERIALS AND METHODS:A group of 40 partially edentulous patients were selected for this study. Thei...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00397.x
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Information on the microbiota in peri-implantitis is limited. We hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. MATERIALS AND METHODS:Baseline microbiological samples collected at one implant in each of 166 participants with pe...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12052
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Elicitation of the relationship of periodontopathogens and pro-inflammatory cytokines to bone resorption and formation is significant to a growing body of research known as osteoimmunology. It is essential that clinically healthy peri-implant and periodontal sites are studied to contribute comparison data fo...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2007.00076.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Long-term data (>10 years) concerning the survival and success rates of implants and implant-supported prostheses are scarce. PURPOSE:The present investigation represents one of the first studies on dental implants covering an observational period of 25 years. MATERIALS AND METHODS:This study presents the ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12944
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The original Brånemark protocol for dental implant treatment was based on submerged healing prior to loading. However, immediate loading has been reported possible with high success rates for various indications, provided that good bone quality and quantity are present. In many of these studies, machined-sur...
journal_title:Clinical implant dentistry and related research
pub_type: 临床试验,杂志文章
doi:10.1111/j.1708-8208.2003.tb00015.x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Clinical studies show promising outcomes with implants inserted at the time of extraction. However, this often results in an initial bone defect at the marginal region which preferably should heal for an optimal function. Therefore, monitoring of these implants is vital. PURPOSES:The aims of this study were...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00095.x
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The replacement of a single tooth or several teeth by means of single-implant restorations is an increasingly used method that needs long-term validation. PURPOSE:The goal of this study was to evaluate the outcome of single-implant restorations by means of fixed restorations and to define the prognosis thro...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2000.tb00119.x
更新日期:2000-01-01 00:00:00