Abstract:
INTRODUCTION:Tumour response in lung cancer treatment is monitored by measuring lesion size in computed tomography (CT). Spectral CT (SCT) offers additional information on tumour tissue besides morphology. We evaluated SCT iodine content (IC) and performed spectral slope analysis to assess the response of non-small-cell lung cancer (NSCLC) to chemoradiotherapy (CRT). METHODS:Eighty-three patients with advanced NSCLC treated by CRT prospectively underwent single-phase, contrast-enhanced SCT. Evaluation of all patients included treatment response (RECIST 1.1), quantitative measurements as well as SCT IC determination and spectral slope analysis in NSCLC primaries. Measurements were performed at the maximum cross-diameter of tumours and in areas with high iodine values (hotspot analysis). Iodine difference (ΔIC) was calculated. Secondary outcome parameters were IC and spectral slopes in mediastinal lymph nodes (n = 61). RESULTS:Twenty-four patients (29%) showed complete remission after CRT. Thirty-four patients (41%) had stable disease (SDSCT ) or partial regression (PRSCT ). Progressive disease (PDSCT ) was seen in 25 patients (30%). Hotspot analysis showed significantly higher iodine values in PDSCT than in SDSCT /PRSCT (P < 0.001). Ten patients (12%) with initially stable disease in SCT showed progressive disease during follow-up for up to 18 months (PDFU ). These patients also had significantly higher hotspot iodine values and ΔIC in the initial scan compared to patients with SD throughout the follow-up period (SDFU ) (29%) (P < 0.001). Enlarged lymph nodes showed significantly lower iodine content and a lower spectral slope pitch than normal-sized nodes (P = 0.003 to 0.029). CONCLUSION:Spectral CT-derived iodine content of NSCLC following CRT may help in predicting recurrence. Hotspot analysis and iodine heterogeneity allow the identification of residual vascularisation as an indicator of vital tumour tissue, indicating that IC might be a suitable imaging biomarker for predicting tumour progression. Iodine content and spectral slope analysis might also help in identifying metastatic lymph nodes.
journal_name
J Med Imaging Radiat Oncoljournal_title
Journal of medical imaging and radiation oncologyauthors
Fehrenbach U,Feldhaus F,Kahn J,Böning G,Maurer MH,Renz D,Frost N,Streitparth Fdoi
10.1111/1754-9485.12926subject
Has Abstractpub_date
2019-10-01 00:00:00pages
641-649issue
5eissn
1754-9477issn
1754-9485journal_volume
63pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to assess the diagnostic accuracy of our early experience with contrast-enhanced ultrasound (CEUS) in the characterisation of focal liver lesions (FLLs) using histopathology, contrast-enhanced computed tomography (CT), magnetic resonance imaging (MRI) or other imaging follow-up as ...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2010.02195.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:There is limited long-term prospective data on the use of endovascular techniques and the use of thrombolysis in malfunctioning autologous haemodialysis fistulas. PURPOSE:Prospective assessment of clinical outcomes following angioplasty with or without low-dose thrombolysis was undertaken in patients who pr...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2010.02216.x
更新日期:2010-12-01 00:00:00
abstract::Vascular anomalies encompass a broad spectrum of tumours and malformations as classified by the International Society for the Study of Vascular Anomalies. Despite being one of the most common congenital abnormalities, they are often misunderstood in clinical practice: use of the term 'haemangioma' to denote any vascul...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1754-9485.2012.02342.x
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:Duplex kidneys are common, mostly asymptomatic and of no clinical significance. However, they can be associated with significant pathology, often with long-term morbidity. There is minimal literature on the review of the duplex kidney, its associated anomalies and complications. The purpose of this paper i...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/1754-9485.12285
更新日期:2015-04-01 00:00:00
abstract::Congenital extrahepatic portocaval shunt is a rare condition that is described mostly in female patients. We report an unusual case of a young adult male patient with type 1 congenital extrahepatic portocaval shunt with associated development of a focal nodular hyperplasia on a background of regenerative nodules. With...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2011.02303.x
更新日期:2011-10-01 00:00:00
abstract::Whole-body MRI is an effective method for evaluating the entire skeletal system in patients with metastatic disease. This study aimed to compare whole-body MRI and radionuclide bone scintigraph in the detection of skeletal metastases in patients with prostate cancer. Patients with prostate cancer at high risk of skele...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2009.02070.x
更新日期:2009-06-01 00:00:00
abstract::We report the case of who has been hospitalized complaining about fever in the last 4 days. Laboratory data revealed lymphocytopenia and leucopenia with an elevation of C-reactive protein and positive real-time reverse transcription-polymerase chain reaction (RT-PCR). Six days before this hospitalization, when the pat...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.13099
更新日期:2020-10-01 00:00:00
abstract::This article describes the technique of saphenous vein peripherally inserted central catheter placement, which is used as an alternative site for venous access in our institution, and examines saphenous vein peripherally inserted central catheter safety issues and indications. Three end-stage renal failure patients, t...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1440-1673.2007.01914.x
更新日期:2008-02-01 00:00:00
abstract::A 75-year-old man presented with a spontaneous right pneumothorax and pneumopericardium following right atrial pacemaker lead perforation, which is a rare complication, with only two case reports being documented in the literature to the authors' knowledge. It is important that radiologists be aware of cardiac lead pe...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12200
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:We present the results of a pilot study to test the feasibility of a brachytherapy dosimetry audit. METHODS:The feasibility study was conducted at seven sites from four Australian states in both public and private centres. A purpose-built cylindrical water phantom was imaged using the local imaging protoc...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12042
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Having previously modelled the optimal proportion of uterine cervix and corpus cancers that should be treated with brachytherapy (BT), we aimed to complete the assessment of the role of BT for gynaecological cancers by estimating the optimal proportion of vaginal cancer cases that should be treated with BT...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2012.02392.x
更新日期:2012-08-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate the dynamic volumetric CT in the assessment of the paediatric airway. METHODS:Ethics board approval was obtained for this retrospective review. Eight infants (median age 6 months, range 3 weeks to 1 year, 50% female) at a tertiary paediatric centre with complex clinic...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12009
更新日期:2013-04-01 00:00:00
abstract::Advances in interventional radiology have seen the adaptation of urological endoscopic laser techniques to treat biliary tract calculi. Percutaneous transhepatic biliary laser lithotripsy provides an effective alternative procedure for the management of intrahepatic or conventionally refractory choledocholithiasis whi...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12952
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:Computed tomography colonography (CTC) for the detection of colorectal disease is gaining popularity as an alternative to colonoscopy. This has been associated with an increase in incidental extra-colonic findings such as abdominal aortic aneurysms. However, due to the patient selection process of obtainin...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12535
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:TROG 09.03 prospectively studied the utility of Fluorine-18 Fluorodeoxyglucose (18-FDG) PET in the management of Merkel cell carcinoma of skin. METHODS:Following consent and registration, a pre-treatment FDG-PET/CT was performed. Sites of avid disease were confirmed by cytology where practicable. Followin...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12705
更新日期:2018-06-01 00:00:00
abstract::Adhesive capsulitis is one of the most common conditions affecting the shoulder; however, early clinical diagnosis can be challenging. Treatment is most effective when commenced prior to the onset of capsular thickening and contracture; consequently, the role of imaging is increasing. The aim of this review is to demo...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/1754-9485.12111
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:To describe cases omental haemorrhage and to review the literature on this topic. METHODS:We describe three cases of spontaneous omental haemorrhage and discuss various management strategies, in an attempt to provide direction for similar cases in the future. RESULTS:A number of case reports of spontaneo...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.13024
更新日期:2020-06-01 00:00:00
abstract::Obstructive sleep apnoea (OSA) is a serious worldwide health problem. Moderate-to-severe OSA has been found in up to 50% of men and 25% of women in the middle-aged population. It results in a fourfold increase in all causes of mortality. The prevalence of OSA is underestimated, partly due to absence of symptoms but al...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/1754-9485.12978
更新日期:2020-02-01 00:00:00
abstract::In New South Wales (NSW) from 1996 to 2006, only 34-37% of newly diagnosed cancer patients were treated with radiotherapy instead of the 50% proposed by NSW Health in Radiotherapy Plans released in 1991, 1995 and 2003. As a consequence, over 50 000 cancer patients were not treated and has resulted in the estimated pre...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2009.02098.x
更新日期:2009-08-01 00:00:00
abstract::Acute gastric volvulus is a rare surgical emergency which can lead to severe complications such as gastric ischaemia and perforation. Gastric volvulus is classified by the axis upon which the stomach rotates into organo-axial and mesentero-axial subtypes, with the former more common in adults. We present an uncommon c...
journal_title:Journal of medical imaging and radiation oncology
pub_type:
doi:10.1111/1754-9485.13051
更新日期:2020-12-01 00:00:00
abstract::The objective of this study was to evaluate the sensitivity of ultrashort echo time (uTE) sequence for visualisation of calcified deep layers of articular cartilage. MRI with a uTE sequence was performed on five healthy volunteers. Signals from the calcified deep layers of the articular knee cartilage were evaluated o...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2012.02388.x
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:Common peroneal nerve (CPN) injury occurs in 10-40% of patients following knee dislocation. Is magnetic resonance imaging (MRI) using routine knee protocols able to adequately evaluate CPN injury and predict long-term outcome? METHODS:Trauma patients presenting for knee MRI at a single public hospital, be...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12840
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION:Marker clips are commonly deployed at the site of a percutaneous breast biopsy. Studies have shown that displacement of the clip from the site of deployment is not uncommon. The objective of this study was to determine how much 'migration' could be seen with fixed structures within the breast tissue across...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12327
更新日期:2015-10-01 00:00:00
abstract::The retroperitoneal space is made up of multiple communicating compartments. Here we detail an unusual case of ectopic gas almost exclusively isolated to the properitoneal space, a space in communication with the retroperitoneum. This case is a reminder that when extraperitoneal gas is identified, the retroperitoneal ...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12820
更新日期:2019-02-01 00:00:00
abstract::Deep Inspiration Breath-Hold (DIBH) techniques for breast cancer radiation therapy (RT) have reduced cardiac dose compared to Free Breathing (FB). Recently, a voluntary deep inspiration breath-hold (vDIBH) technique was established using in-room lasers and skin tattoos to monitor breath-hold. An in-house quality asses...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12616
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:The goal of this study was to use liver explant correlation to assess the diagnostic accuracy of diffusion-weighted (DW)-MRI for hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Thirty-seven patients were retrospectively identified who had undergone liver transplantation and had preoperative, respirato...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2011.02286.x
更新日期:2011-08-01 00:00:00
abstract::Radiotherapy plays a significant role in the palliation of symptoms in patients with cancer. It can improve symptoms from bone metastases, spinal cord compression, superior vena cava obstruction and cerebral metastases. Long waiting lists and inconvenient access prolong suffering and may even discourage patients from ...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2010.02141.x
更新日期:2010-02-01 00:00:00
abstract::Patients with colorectal cancer undergo frequent diagnostic imaging to stage the extent of metastatic disease and assess response to treatment. Imaging is typically via diagnostic contrast-enhanced CT or combined FDG-PET/CT. However, recent research has demonstrated promising benefits of combined FDG-PET/MRI in oncolo...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/1754-9485.12936
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION:We compared integral dose with uninvolved brain (IDbrain ) during partial brain radiotherapy (PBRT) for high-grade glioma patients using helical tomotherapy (HT) and seven field traditional inverse-planned intensity-modulated radiotherapy (IMRT) with and without selective sparing (SPA) of contralateral hip...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12048
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:To assess laryngeal motion in early glottic cancer in order to determine safe margins for partial larynx volumetric modulated arc therapy (PL-VMAT), and to quantify dosimetric advantages of PL-VMAT. METHODS:This prospective study included T1-2N0 glottic cancers treated with whole larynx VMAT (WL-VMAT). Pr...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12612
更新日期:2017-10-01 00:00:00