Diagnostic accuracy of diffusion-weighted MRI for identifying hepatocellular carcinoma with liver explant correlation.

Abstract:

BACKGROUND:The goal of this study was to use liver explant correlation to assess the diagnostic accuracy of diffusion-weighted (DW)-MRI for hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Thirty-seven patients were retrospectively identified who had undergone liver transplantation and had preoperative, respiratory-triggered, single-shot echo-planar DW-MRI. Two independent blinded observers evaluated the DW-MRI images for HCC and comparison was made with the explanted specimens. RESULTS:By pathology, 29 HCCs (mean largest diameter 2.0 cm; range 0.7-4.0 cm) were identified in 20 patients. Sensitivity and specificity for reader 1 were 55 and 92%, and for reader 2 were 45 and 100%. There was 'substantial' inter-observer agreement (kappa = 0.64). CONCLUSION:DW-MR is not sensitive enough for HCC to be used as a stand-alone sequence, although its high specificity suggests that it is likely valuable as a component of a liver MRI protocol.

authors

Hardie AD,Kizziah MK,Boulter DJ

doi

10.1111/j.1754-9485.2011.02286.x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

362-7

issue

4

eissn

1754-9477

issn

1754-9485

journal_volume

55

pub_type

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