Abstract:
BACKGROUND:The hypothesis that vertebrates have experienced two ancient, whole genome duplications (WGDs) is of central interest to evolutionary biology and has been implicated in evolution of developmental complexity. Three-way and Four-way paralogy regions in human and other vertebrate genomes are considered as vital evidence to support this hypothesis. Alternatively, it has been proposed that such paralogy regions are created by small-scale duplications that occurred at different intervals over the evolution of life. RESULTS:To address this debate, the present study investigates the evolutionary history of multigene families with at least three-fold representation on human chromosomes 1, 2, 8 and 20. Phylogenetic analysis and the tree topology comparisons classified the members of 36 multigene families into four distinct co-duplicated groups. Gene families falling within the same co-duplicated group might have duplicated together, whereas genes belong to different co-duplicated groups might have distinct evolutionary origins. CONCLUSION:Taken together with previous investigations, the current study yielded no proof in favor of WGDs hypothesis. Rather, it appears that the vertebrate genome evolved as a result of small-scale duplication events, that cover the entire span of the animals' history.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Pervaiz N,Shakeel N,Qasim A,Zehra R,Anwar S,Rana N,Xue Y,Zhang Z,Bao Y,Abbasi AAdoi
10.1186/s12862-019-1441-0subject
Has Abstractpub_date
2019-06-20 00:00:00pages
128issue
1issn
1471-2148pii
10.1186/s12862-019-1441-0journal_volume
19pub_type
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journal_title:BMC evolutionary biology
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