Abstract:
BACKGROUND:Septins are cytoskeletal GTPase proteins first discovered in the fungus Saccharomyces cerevisiae where they organize the septum and link nuclear division with cell division. More recently septins have been found in animals where they are important in processes ranging from actin and microtubule organization to embryonic patterning and where defects in septins have been implicated in human disease. Previous studies suggested that many animal septins fell into independent evolutionary groups, confounding cross-kingdom comparison. RESULTS:In the current work, we identified 162 septins from fungi, microsporidia and animals and analyzed their phylogenetic relationships. There was support for five groups of septins with orthology between kingdoms. Group 1 (which includes S. cerevisiae Cdc10p and human Sept9) and Group 2 (which includes S. cerevisiae Cdc3p and human Sept7) contain sequences from fungi and animals. Group 3 (which includes S. cerevisiae Cdc11p) and Group 4 (which includes S. cerevisiae Cdc12p) contain sequences from fungi and microsporidia. Group 5 (which includes Aspergillus nidulans AspE) contains sequences from filamentous fungi. We suggest a modified nomenclature based on these phylogenetic relationships. Comparative sequence alignments revealed septin derivatives of already known G1, G3 and G4 GTPase motifs, four new motifs from two to twelve amino acids long and six conserved single amino acid positions. One of these new motifs is septin-specific and several are group specific. CONCLUSION:Our studies provide an evolutionary history for this important family of proteins and a framework and consistent nomenclature for comparison of septin orthologs across kingdoms.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Pan F,Malmberg RL,Momany Mdoi
10.1186/1471-2148-7-103subject
Has Abstractpub_date
2007-07-01 00:00:00pages
103issn
1471-2148pii
1471-2148-7-103journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Owing to its independence from the main Central European drainage systems, the Italian freshwater fauna is characterized by a high degree of endemicity. Three main ichthyogeographic districts have been proposed in Italy. Yet, the validity of these regions has not been confirmed by phylogenetic and population...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-10-111
更新日期:2010-04-27 00:00:00
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journal_title:BMC evolutionary biology
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pub_type: 杂志文章
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更新日期:2011-04-19 00:00:00
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更新日期:2019-01-25 00:00:00
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更新日期:2015-09-16 00:00:00
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pub_type: 杂志文章
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更新日期:2007-03-02 00:00:00
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更新日期:2014-02-18 00:00:00
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pub_type: 杂志文章
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更新日期:2008-10-02 00:00:00
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pub_type: 杂志文章
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更新日期:2012-03-19 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-04 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-30 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-06 00:00:00
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更新日期:2018-07-03 00:00:00
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更新日期:2007-08-06 00:00:00
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更新日期:2016-04-12 00:00:00
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更新日期:2017-04-14 00:00:00
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pub_type: 杂志文章
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更新日期:2008-03-06 00:00:00
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更新日期:2010-04-30 00:00:00
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更新日期:2013-08-13 00:00:00
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更新日期:2010-05-17 00:00:00
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pub_type: 杂志文章
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更新日期:2003-05-23 00:00:00
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更新日期:2011-05-28 00:00:00
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pub_type: 杂志文章
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更新日期:2014-08-28 00:00:00