Abstract:
:The purpose of this study was to explore lymphocyte subsets of newly diagnosed DLBCL patients, and dynamics along with treatment of R-CHOP. A total of 40 DLBCL patients were enrolled. ALC of grade III-IV DLBCL patients was significantly lower than that of health controls (1.33*10E9/L vs 1.89*10E9/L, p = 0.003), mostly attributing to decreased CD4+ cells (p = 0.012). And serum LDH level of patients was negatively correlated with ALC (p = 0.033). ALC progressively decreased along with treatment, so as to CD3+, CD4+ and CD19+ cells, while proportion of CD4+ and CD8+ cells increased significantly after two cycles' treatment (p < 0.05). CR of ALC low (<1.18*10E9/L) group was lower than that of ALC high group (37.5% vs 73.3%), though not statistically significant (p = 0.179).
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Yang Z,Yu W,Wang S,Zhou X,Liu S,Ma Sdoi
10.1080/10428194.2019.1617861subject
Has Abstractpub_date
2019-12-01 00:00:00pages
2909-2916issue
12eissn
1042-8194issn
1029-2403journal_volume
60pub_type
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