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Effects of transcranial direct current stimulation on symptoms of nicotine dependence: A systematic review and meta-analysis.

Abstract：

:The purpose of this systematic review and meta-analysis was to investigate the effects of transcranial direct current stimulation (tDCS) on symptoms of nicotine dependence in treatment-seeking smokers. Twelve studies qualified for this meta-analysis, and we used 15 total comparisons from the included studies for the data synthesis. Primary outcome measures were changes in (a) cue-provoked craving and (b) smoking intake (i.e., the number of cigarettes smoked) between active tDCS stimulation and sham control groups. Random-effects model meta-analyses revealed significant positive effects of tDCS on seven cue-provoked craving comparisons (effect size = 0.422; P = .004) and eight smoking intake comparisons (effect size = 0.557; P = .004). Moderator variable analyses indicated that applying anodal-tDCS on the right dorsolateral prefrontal cortex (DLPFC) revealed significant positive effects on the cue-provoked craving with minimal heterogeneity. Further, applying cathodal-tDCS on DLPFC regions showed more positive effects on both cue-provoked craving and smoking intake than cathodal-tDCS on other brain regions. These findings suggested that tDCS modulating DLPFC activity can be an effective option for decreasing individual's smoking dependence symptoms.

journal_name

Addict Behav

journal_title

Addictive behaviors

authors

Kang N,Kim RK,Kim HJ

doi

10.1016/j.addbeh.2019.05.006

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

133-139

eissn

0306-4603

issn

1873-6327

pii

S0306-4603(19)30272-2

journal_volume

96

pub_type

杂志文章,meta分析

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