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Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: Clinical case and literature review.

Abstract：

INTRODUCTION:Natalizumab break exposes multiple sclerosis (MS) patients to a high risk of disease reactivation or rebound, whose prevention and treatment constitute a clinical challenge. CASE PRESENTATION:We describe a dramatic case of MS rebound, characterized by the development of severe neurological and psychiatric symptoms, following natalizumab break. Alemtuzumab rapidly and completely suppressed brain inflammation as demonstrated by clinical and radiological findings. CONCLUSIONS:Our case further adds to the available literature evidence on Alemtuzumab as first-choice rescue therapy following Natalizumab discontinuation.

journal_name

Mult Scler Relat Disord

journal_title

Multiple sclerosis and related disorders

authors

Federle L,Puthenparampil M,Stenta G,Paolo G,Francesco P

doi

10.1016/j.msard.2019.03.002

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

262-264

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(19)30107-5

journal_volume

30

pub_type

杂志文章,评审

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