Abstract:
:Treatment-related fatigue significantly limits quality of life among chronic myeloid leukemia (CML) patients receiving tyrosine kinase inhibitors (TKIs), yet no interventions to reduce this symptom have been studied. We examined preliminary feasibility and efficacy of cognitive behavioral therapy for TKI treatment-related fatigue in patients with CML. We used a mixed methods convergent design and collected quantitative data through randomized single-case experiments. We included CML patients receiving TKIs and reporting severe fatigue. Within each participant, we compared CBT to a no-treatment baseline period. Fatigue severity was measured weekly with the Checklist Individual Strength. Fatigue scores were subjected to visual analyses and randomization tests for single-case experimental designs. We conducted qualitative interviews after study participation and focused on feasibility and efficacy of CBT. Visual inspection of line graphs indicated downward trends in the expected direction for fatigue in two of the four participants. The test statistics showed a decrease in fatigue severity for all participants but randomization tests did not reach statistical significance (overall p = 0.18). Participants reported qualitative improvements in level of functioning and coping with fatigue. CBT was considered feasible and acceptable for severely fatigued CML patients. Our study provided preliminary evidence for the feasibility and acceptability of CBT for severely fatigued CML patients receiving targeted therapy. We recommend further efficacy testing of this promising intervention in a pilot randomized controlled trial.
journal_name
J Clin Psychol Med Settingsjournal_title
Journal of clinical psychology in medical settingsauthors
Poort H,Onghena P,Abrahams HJG,Jim HSL,Jacobsen PB,Blijlevens NMA,Knoop Hdoi
10.1007/s10880-019-09607-5subject
Has Abstractpub_date
2019-12-01 00:00:00pages
440-448issue
4eissn
1068-9583issn
1573-3572pii
10.1007/s10880-019-09607-5journal_volume
26pub_type
杂志文章abstract::This article begins by contextualizing specialization and board certification of psychologists, with attention paid to relevant definitions and expectations of other health care professionals. A brief history of specialization and board certification in professional psychology is offered. The benefits of board certifi...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-011-9273-0
更新日期:2012-03-01 00:00:00
abstract::Research demonstrates that severe forms of grief and grief-related pathology exist in the general population. Less attention, however, has been paid to the grief of parents following the death of a young, dependent child. In this review, we summarize a search of Pubmed, PsycINFO and Web of Science from 1995 to 2017, u...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章,评审
doi:10.1007/s10880-018-9590-7
更新日期:2019-09-01 00:00:00
abstract::Antenatal and postpartum depression has been associated with maternal, child and family-unit complications. Our aim was to assess the impact of a depression screening and intervention program on perinatal complications. This study included 2042 women. They were screened on the Edinburgh Postnatal Depression Scale (EPD...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-019-09632-4
更新日期:2020-03-01 00:00:00
abstract::We examined the relationship between two malleable risk factors, depressive symptoms and fear of hypoglycemia, in children and adolescents with Type 1 diabetes and their relationship to two important outcomes, adherence behaviors and metabolic control. To assess this relationship, we used a multidimensional measure of...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-019-09676-6
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/BF01988630
更新日期:1995-03-01 00:00:00
abstract::Parent reported behavioral difficulties in young children are relatively common. Without adequate intervention, some children will later present with more severe problem behaviors. Parent management training is one of the best methods of treatment for behavior problems; however, existing treatments can be lengthy and ...
journal_title:Journal of clinical psychology in medical settings
pub_type: 临床试验,杂志文章
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更新日期:2009-09-01 00:00:00
abstract::The present study investigated whether differing diagnostic criteria for alcoholism used by mental health professionals versus hepatologists lead to different outcomes in predicting liver transplant survival as determined by the medical record and without a priori judgments. This was in contrast to past studies, parti...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-010-9201-8
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abstract::Rapidly occurring changes in the healthcare arena mean time is of the essence for psychology to formalize a strategic plan for training in primary care settings. The current article articulates factors affecting models of integrated care in Academic Health Centers (AHCs) and describes ways to identify and utilize reso...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-011-9291-y
更新日期:2012-03-01 00:00:00
abstract::Noting a lack of such a resource, the authors developed a primer summarizing key concepts for career development and promotion for psychologists working in an academic health center. The present article presents a brief summary of the primer; however, the full version is available as an APAHC membership benefit (or fo...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-012-9334-z
更新日期:2012-12-01 00:00:00
abstract::This is the first controlled study regarding personality and psychopathology in adults with Noonan syndrome (NS). Anxiety, depression, alexithymia and symptoms of Attention Deficit-Hyperactivity Disorder and Autism Spectrum Disorder, have been previously described in NS. More information regarding personality and psyc...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-019-09659-7
更新日期:2020-06-01 00:00:00
abstract::The current study examined the link between immune functioning (CD4 count) and physical symptoms, as well as the moderating role of optimism and depressive symptoms, in a sample of 99 low income, inner city African American women with HIV. Although there was no main effect of CD4 count on physical symptoms, depressive...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-008-9133-8
更新日期:2008-12-01 00:00:00
abstract::This longitudinal study investigated levels of anxiety and depression in women who underwent clinical investigations to diagnose a possible ovarian cancer. Women completed the Hospital Anxiety and Depression Scale (HADS), prior to clinical investigations (Time 1), after receiving diagnostic results (Time 2) and at 3 m...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-010-9196-1
更新日期:2010-06-01 00:00:00
abstract::Disability in inflammatory bowel disease (IBD) is under-investigated. Models theorize that disability is the result of a disease and its related impairments, limitations, and restrictions. This disablement process can be affected by psychosocial factors. Pain, depression, catastrophizing, and social support are associ...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-019-09627-1
更新日期:2020-03-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-008-9138-3
更新日期:2009-03-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-015-9438-3
更新日期:2016-06-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-011-9231-x
更新日期:2011-03-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s10880-012-9324-1
更新日期:2012-12-01 00:00:00
abstract::Adherence and glycemic control usually decrease during adolescence and family relationships influence diabetes outcomes. This study analyzed the interaction effect of adolescents' family support, age, and gender in the relationship between adherence and glycemic control in adolescents with Type 1 Diabetes. The sample ...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-019-09662-y
更新日期:2020-06-01 00:00:00
abstract::We examined the relationships between promotion and prevention focus and caloric consumption in reaction to a dietary lapse scenario among weight loss maintainers. Participants were 65 adult females who had attained and maintained a weight loss of 10 % or more for at least 1 month. After engaging in a dietary lapse in...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-015-9421-z
更新日期:2015-03-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-013-9368-x
更新日期:2013-12-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章,评审
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journal_title:Journal of clinical psychology in medical settings
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
abstract::Treatments for depression and anxiety in multiple sclerosis (MS) are effective but evidence suggests that individuals do not always seek help for emotional difficulties. This study explored how ten women with MS (aged 30-64), recruited via a hospital based MS clinic, coped with and understood their emotions. The semi-...
journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/s10880-014-9408-1
更新日期:2014-12-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/BF01990884
更新日期:1995-09-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章,评审
doi:10.1007/s10880-018-9542-2
更新日期:2018-09-01 00:00:00
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
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journal_title:Journal of clinical psychology in medical settings
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journal_title:Journal of clinical psychology in medical settings
pub_type: 杂志文章
doi:10.1007/BF01999744
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