Abstract:
:As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically acceptable polymer) can be deposited on the surface of amorphous indomethacin by electrostatic deposition, leading to significant improvement of physical stability, wetting by aqueous media, dissolution rate, powder flow, and tabletability. The coating condition was chosen so that the positively charged polymer deposits on the negatively charged drug. Chitosan coating is superior to gelatin coating with respect to stability against crystallization and agglomeration of coated particles.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Li Y,Yu J,Hu S,Chen Z,Sacchetti M,Sun CC,Yu Ldoi
10.1021/acs.molpharmaceut.8b01237subject
Has Abstractpub_date
2019-03-04 00:00:00pages
1305-1311issue
3eissn
1543-8384issn
1543-8392journal_volume
16pub_type
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