Abstract:
:Recent developments in pharmaceutical technology have facilitated the design and production of modified release formulas for drugs whose physical, chemical or biological properties impede release and thus might compromise their efficacy or safety. One such drug is morphine, whose short half-life requires repeated doses at short intervals. The use of biocompatible polymers such as ethylcellulose has made it possible to develop microencapsulated formulations which facilitate liquid, sustained-release pharmaceutical formulas for oral administration. We developed a stable final formulation of morphine with an acceptable release profile by comparing the rheological properties and stability of formulations with different thickeners (xanthan gum, Carbopol, and carboxymethylcellulose with microcrystalline cellulose) at different concentrations from 0.25% to 1.0%. Release assays in a Franz-type cell were done to determine the most suitable release profile for the formulation.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Morales ME,López G,Gallardo V,Ruiz MAdoi
10.1021/mp200019qsubject
Has Abstractpub_date
2011-04-04 00:00:00pages
629-34issue
2eissn
1543-8384issn
1543-8392journal_volume
8pub_type
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