Airway Remodeling in Asthma: Evaluation in 5 Consecutive Bronchial Generations by Using High-Resolution Computed Tomography.

Abstract:

BACKGROUND:Airway remodeling is a characteristic structural change that occurs extensively in the airways of patients with asthma. The change can be evaluated by measuring airway dimensions by using high-resolution computed tomography. This study aimed to explore the variation trends of airway dimensions from the second- to sixth-generation bronchi in subjects with asthma. METHODS:Sixty subjects with asthma and 40 healthy controls underwent high-resolution computed tomography. The right upper lobe apical segmental bronchus, right lower lobe posterior basal segmental bronchus, left upper lobe apicoposterior segmental bronchus, and the left lower lobe posterior basal segmental bronchus were identified on computed tomography images. The luminal area, wall area, and wall area percentage of each bronchus were measured from the second (lobar) to the sixth generation. The variation trends of these indices (luminal area, wall area, and wall area percentage) were then compared between the subjects with asthma and the healthy controls. RESULTS:From the proximal to the distal airway, the luminal area and wall area decreased gradually, whereas the wall area percentage increased gradually in all the participants; the difference between the participants with asthma and the healthy controls in the luminal area, wall area, and wall area percentage increased gradually from the second (lobar) to the sixth generation; there was a significant difference between the participants with asthma and the healthy controls in the right lower lobe posterior basal segmental bronchus, left upper lobe apicoposterior segmental bronchus, and left lower lobe posterior basal segmental bronchus wall area percentage (P = .001, .01 and .001, respectively) but not in the right upper lobe apical segmental bronchus wall area percentage (P = .050). CONCLUSIONS:Airway remodeling in asthma was more prominent in distal airways and at lower lobe bronchi.

journal_name

Respir Care

journal_title

Respiratory care

authors

Jiang D,Wang Z,Yu N,Shen C,Deng L,Guo Y

doi

10.4187/respcare.06050

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1399-1406

issue

11

eissn

0020-1324

issn

1943-3654

pii

63/11/1399

journal_volume

63

pub_type

杂志文章
  • Variation Among Spirometry Interpretation Algorithms.

    abstract::Several algorithms exist to facilitate spirometric interpretation in clinical practice, yet there is a lack of consensus on how spirometric criteria for asthma, COPD, and restrictive disorders should be incorporated into spirometry interpretation algorithms suitable for use in day-to-day primary care management. The p...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.07294

    authors: D'Urzo KA,Mok F,D'Urzo AD

    更新日期:2020-10-01 00:00:00

  • The clinical impact of new long-term oxygen therapy technology.

    abstract::Long-term oxygen therapy (LTOT) improves survival for patients afflicted with severe chronic obstructive pulmonary disease and may also reduce the incidence of repeat hospitalization due to exacerbations. When properly dosed and titrated, LTOT has also been shown to improve exercise tolerance, thereby enhancing the ov...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Dunne PJ

    更新日期:2009-08-01 00:00:00

  • Aerosolized medications for altering lung surface active properties.

    abstract::Surface active material is important in the function of both the infant and adult lung. In the premature infant, surfactant depletion results in the requirement for very high distending pressures to open alveoli. As a consequence, shunt, hypoxemia, and right ventricular dysfunction occur. Surfactant replacement, espec...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: MacIntyre NR

    更新日期:2000-06-01 00:00:00

  • Acute inhalation injury with evidence of diffuse bronchiolitis following chlorine gas exposure at a swimming pool.

    abstract::A previously healthy 23-year-old man with nonproductive cough and sore throat presented to the hospital a few hours after chlorine gas exposure at a fitness center swimming pool. Initial physical examination and chest radiograph were normal. Thirty-six hours later he developed worsening dyspnea and cough, with develop...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Parimon T,Kanne JP,Pierson DJ

    更新日期:2004-03-01 00:00:00

  • Impact of a radio frequency management information system on the process and timing of providing respiratory care services.

    abstract:BACKGROUND:Although radio frequency (RF) systems have proliferated and are designed to simplify care delivery in many clinical settings, little information is available on the impact of such RF systems on the delivery of patient care. Having used a hand-held-device-based management information system in our Respiratory...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Stoller JK,Kester L,Orens DK,McCarthy K

    更新日期:2002-08-01 00:00:00

  • Reciprocal influence of refractory hypoxemia and high intracranial pressure on the postoperative management of an urgent neurosurgical procedure.

    abstract::A 20-year-old man was admitted in the neurology ICU after the drainage of a large frontal hematoma related to the spontaneous bleeding of a recently diagnosed cavernoma. On admission the Glasgow coma score was 4/15, with evidence of sub-falcorial herniation and elevated intracranial pressure. On the 4th postoperative...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.01322

    authors: Vanhoonacker M,Roeseler J,Hantson P

    更新日期:2012-07-01 00:00:00

  • Computerized adventitious respiratory sounds as outcome measures for respiratory therapy: a systematic review.

    abstract:INTRODUCTION:There is a need to develop simple, noninvasive, and sensitive outcome measures for respiratory therapy. Adventitious respiratory sounds (ie, crackles and wheezes) can be objectively characterized with computerized respiratory sound analysis (CORSA) and have been shown to contribute for diagnosis purposes; ...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.02765

    authors: Marques A,Oliveira A,Jácome C

    更新日期:2014-05-01 00:00:00

  • Comparison of Flow Resistance Characteristics and Placement of Two Endotracheal Tubes.

    abstract:BACKGROUND:In a traditional endotracheal tube (ETT), there is a linear outward pull through its attachment to the ventilator tubing that leads to risk of accidental dislodgement. This study was conducted to assess the ETT flow characteristics and to evaluate providers' intubation experience using two ETT's in a simulat...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.05813

    authors: Deshpande GG,Sanford JE,Tripathi S

    更新日期:2018-09-01 00:00:00

  • The importance of nonelectrostatic materials in holding chambers for delivery of hydrofluoroalkane albuterol.

    abstract:INTRODUCTION:Electrostatic attraction of aerosolized particles to the inner walls of an aerosol holding chamber (HC) made from a nonconducting material can reduce medication delivery, particularly if there is a delay between actuation and inhalation. OBJECTIVE:Compare total emitted mass and fine-particle mass (mass of...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Rau JL,Coppolo DP,Nagel MW,Avvakoumova VI,Doyle CC,Wiersema KJ,Mitchell JP

    更新日期:2006-05-01 00:00:00

  • Congenital pulmonary airway malformation: a case report and review of the literature.

    abstract::Congenital parenchymal lung malformations have an estimated incidence at 1:25,000-1:35,000 births. We present a case of this rare congenital abnormality in a 38 year-old male, review the current literature with discussion of proposed causes, malignant potential, and management strategies. A 38-year-old white male pre...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.00727

    authors: McDonough RJ,Niven AS,Havenstrite KA

    更新日期:2012-02-01 00:00:00

  • Noninvasive ventilation for acute respiratory failure: a national survey of Veterans Affairs hospitals.

    abstract:BACKGROUND:The utilization of noninvasive ventilation (NIV) in the Veterans Affairs health-care system is not well characterized. A survey of physicians and respiratory therapists was conducted to better understand its use. METHODS:Three hospitals in each of 21 Veterans Affairs networks were selected based on severity...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Bierer GB,Soo Hoo GW

    更新日期:2009-10-01 00:00:00

  • Management of acute brain injury and associated respiratory issues.

    abstract::Acute brain injury, in the form of trauma, stroke, or spontaneous hemorrhage, occurs commonly and in all age groups. Although the management of these conditions differs considerably, certain physiologic principles are shared by all and are useful in guiding the management of the most severely injured patients. This ar...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Deem S

    更新日期:2006-04-01 00:00:00

  • Should PEEP Titration Be Based on Chest Mechanics in Patients With ARDS?

    abstract::Functional residual capacity (FRC) is essentially the alveolar volume and a determinant of both oxygenation and respiratory system compliance (CRS). ARDS decreases FRC, and sufficient PEEP restores FRC; thus, assessments of PEEP by its impact on oxygenation and CRS are intimately linked. PEEP also can ameliorate or ag...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.04657

    authors: Kallet RH

    更新日期:2016-06-01 00:00:00

  • Mechanical ventilator design and function: the trigger variable.

    abstract::Because of the design characteristics, flow-triggering appears to offer measurable advantages over pressure-triggering, particularly during spontaneous breathing. During the trigger phase, flow-triggering provides a relatively shorter time delay than pressure-triggering. A trigger sensitivity that does not cause autoc...

    journal_title:Respiratory care

    pub_type: 共识发展会议,杂志文章,评审

    doi:

    authors: Sassoon CS

    更新日期:1992-09-01 00:00:00

  • Weaning from mechanical ventilation: the evidence from clinical research.

    abstract::Mechanical ventilation incurs substantial morbidity, mortality, and costs. Both premature extubation and delayed extubation can cause harm. Therefore, weaning that is both expeditious and safe is highly desirable. The purpose of this review is to summarize the literature related to weaning modes, spontaneous breathing...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Meade MO,Guyatt GH,Cook DJ

    更新日期:2001-12-01 00:00:00

  • Association Between High-Flow Nasal Cannula and End-Expiratory Esophageal Pressures in Premature Infants.

    abstract:BACKGROUND:High-flow nasal cannula (HFNC) is commonly being used to provide noninvasive respiratory support in newborn infants. Continuous distending pressure generated by these devices in preterm infants has not been elucidated. The aim of this work was to determine the association between HFNC flow in L/min and end-e...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.04317

    authors: Iyer NP,Mhanna MJ

    更新日期:2016-03-01 00:00:00

  • Heliox during mechanical ventilation.

    abstract::The indications for heliox during mechanical ventilation are lower-airway obstruction, especially with hypercarbia; need to enhance aerosol delivery to lung periphery; and need to facilitate weaning from mechanical ventilation. Certain ventilators perform relatively well with heliox and are not substantially affected ...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Venkataraman ST

    更新日期:2006-06-01 00:00:00

  • Pediatric Oxygen Therapy: A Review and Update.

    abstract::Oxygen is a colorless, odorless, tasteless gas that is utilized by the body for respiration. Oxygen has played a major role in respiratory care. Oxygen therapy is useful in treating hypoxemia but is often thought of as a benign therapy. After many years of study, we have learned a great deal of the benefits and potent...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.05245

    authors: Walsh BK,Smallwood CD

    更新日期:2017-06-01 00:00:00

  • Can outcomes of intensive care unit patients undergoing tracheostomy be predicted?

    abstract:OBJECTIVE:To determine whether outcomes (mortality and need for intensive care unit [ICU] readmission) of patients undergoing tracheostomy in the ICU can be predicted by common clinical or historical criteria. METHODS:We conducted a retrospective review of data from the medical record and Project Impact database in a ...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:

    authors: Gerber DR,Chaaya A,Schorr CA,Markley D,Abouzgheib W

    更新日期:2009-12-01 00:00:00

  • Determinants of patient adherence to an aerosol regimen.

    abstract::Patient adherence with prescribed inhaled therapy is related to morbidity and mortality. The terms "compliance" and "adherence" are used in the literature to describe agreement between prescribed medication and patient practice, with "adherence" implying active patient participation. Patient adherence with inhaled med...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Rau JL

    更新日期:2005-10-01 00:00:00

  • Role of noninvasive positive-pressure ventilation in postextubation respiratory failure: a meta-analysis.

    abstract:BACKGROUND:There is a need for an intervention that prevents re-intubation in patients who have been weaned off mechanical ventilation. Noninvasive positive-pressure ventilation (NPPV) has been shown to facilitate weaning in mechanically ventilated patients. OBJECTIVES:To assess the effect of NPPV on re-intubation rat...

    journal_title:Respiratory care

    pub_type: 杂志文章,meta分析,评审

    doi:

    authors: Agarwal R,Aggarwal AN,Gupta D,Jindal SK

    更新日期:2007-11-01 00:00:00

  • Evidence-based asthma management.

    abstract::In 2002 the National Asthma Education and Prevention Program published evidence-based guidelines for the diagnosis and management of asthma, but there are some unresolved asthma-management issues that need further research. For asthmatic children inhaled corticosteroids are more beneficial than as-needed use of beta(2...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Kallstrom TJ

    更新日期:2004-07-01 00:00:00

  • The accuracy of transcutaneous PCO2 in subjects with severe brain injury: a comparison with end-tidal PCO2.

    abstract:BACKGROUND:In patients suffering from brain injury, end-tidal PCO2 (PETCO2 ) monitoring is controversial, but transcutaneous PCO2 (PtcCO2 ), which is noninvasive and utilizes immediate display, may be an alternative method. We hypothesized that PtcCO2 would be more accurate than PETCO2 for monitoring PaCO2 in patients ...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.02726

    authors: Rosier S,Launey Y,Bleichner JP,Laviolle B,Jouve A,Malledant Y,Seguin P

    更新日期:2014-08-01 00:00:00

  • Feasibility and effectiveness of an educational program in Italian COPD patients undergoing rehabilitation.

    abstract:BACKGROUND:Self-management education is associated with improvement in quality of life and reduction of hospital admissions. Nevertheless, the data are insufficient to formulate clear recommendations regarding the type and content of education programs for COPD patients, and few data are available on knowledge of the d...

    journal_title:Respiratory care

    pub_type: 临床试验,杂志文章

    doi:10.4187/respcare.01697

    authors: Paneroni M,Clini E,Crisafulli E,Guffanti E,Fumagalli A,Bernasconi A,Cabiaglia A,Nicolini A,Brogi S,Ambrosino N,Peroni R,Bianchi L,Vitacca M

    更新日期:2013-02-01 00:00:00

  • Longitudinal evaluation of compressor/nebulizer performance.

    abstract:BACKGROUND:Inhaled medications are the mainstay of treatment for maintenance of lung health in patients with cystic fibrosis (CF). Compressor/nebulizer units are used an average of 100-120 min/d by patients with CF. Each compressor/nebulizer has unique flow/pressure characteristics that affect particle size distributio...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.02776

    authors: Awad S,Williams DK,Berlinski A

    更新日期:2014-07-01 00:00:00

  • Categorization in Mechanically Ventilated Pediatric Subjects: A Proposed Method to Improve Quality.

    abstract:BACKGROUND:Thousands of children require mechanical ventilation each year. Although mechanical ventilation is lifesaving, it is also associated with adverse events if not properly managed. The systematic implementation of evidence-based practice through the use of guidelines and protocols has been shown to mitigate ris...

    journal_title:Respiratory care

    pub_type: 杂志文章

    doi:10.4187/respcare.04723

    authors: Walsh BK,Smallwood CD,Rettig JS,Thompson JE,Kacmarek RM,Arnold JH

    更新日期:2016-09-01 00:00:00

  • Medication Regimens for Managing COPD Exacerbations.

    abstract::Exacerbations are a hallmark feature of COPD and contribute to morbidity and mortality. There is general agreement that the pharmacotherapy of COPD exacerbations includes bronchodilators, corticosteroids, and antibiotics. Strong evidence exists for the benefit of corticosteroids for exacerbations and of antibiotics in...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:10.4187/respcare.05912

    authors: Putcha N,Wise RA

    更新日期:2018-06-01 00:00:00

  • Care of the ventilator circuit and its relation to ventilator-associated pneumonia.

    abstract::Ventilator circuits should not be changed routinely for infection control purposes. The maximum duration of time that circuits can be used safely is unknown. Evidence is lacking related to ventilator-associated pneumonia (VAP) and issues of heated versus unheated circuits, type of heated humidifier, method for filling...

    journal_title:Respiratory care

    pub_type: 指南,杂志文章,实务指引

    doi:

    authors: Hess DR,Kallstrom TJ,Mottram CD,Myers TR,Sorenson HM,Vines DL,American Association for Respiratory Care.

    更新日期:2003-09-01 00:00:00

  • Emerging gram-negative antibiotic resistance: daunting challenges, declining sensitivities, and dire consequences.

    abstract::Emerging antibiotic resistance has created a major public health dilemma, compounded by a dearth of new antibiotic options. Multidrug-resistant Gram-negative organisms have received less attention than Gram-positive threats, such as methicillin-resistant Staphylococcus aureus, but are just as menacing. Pathogens such ...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Siegel RE

    更新日期:2008-04-01 00:00:00

  • The long-term outcomes of mechanical ventilation: what are they and how should they be used?

    abstract::In the critical care setting, usually the most important outcome is survival. However, this is not the only important outcome of critical care. There are increasing data that the patient's quality of life and functional status can be affected long after an intensive care unit stay, and some data suggest that mechanica...

    journal_title:Respiratory care

    pub_type: 杂志文章,评审

    doi:

    authors: Curtis JR

    更新日期:2002-04-01 00:00:00