Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials.

Abstract:

PURPOSE:Osteoarthritis (OA) is one of the most common causes of disability and a prevalent chronic disease. The use of collagen is growing due to the satisfactory results in the treatment of OA. However, the possible beneficial effects of collagen for the treatment of OA are currently controversial. The aim of the present meta-analysis was to evaluate the effect of collagen-based supplements on OA symptoms. METHODS:PubMed-Medline, Scopus, and Google Scholar databases were searched for randomized placebo-controlled trials evaluating the effect of orally administered collagen on OA symptoms using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale and/or the Visual Analog Scale (VAS). Meta-analysis was conducted using a random-effects model and a generic inverse variance method. Heterogeneity was tested using the I2 statistic index. RESULTS:Collagen treatment showed a significant reduction in the score of total WOMAC index (WMD - 8.00; 95% CI - 13.04, - 2.95; p = 0.002). After subgroup analysis of the WOMAC subscores, the collagen supplementation revealed a significant decrease in the stiffness subscore (WMD - 0.41; 95% CI - 0.74, - 0.08; p = 0.01), whereas the pain (WMD - 0.22; 95% CI - 1.58, 1.13; p = 0.75) and functional limitation (WMD - 0.62; 95% CI - 5.77, 4.52; p = 0.81) subscores did not have significant differences. Finally, a significant reduction was found in the VAS score after collagen administration (WMD - 16.57; 95% CI - 26.24, - 6.89; p < 0.001). CONCLUSION:The results of this meta-analysis showed that collagen is effective in improving OA symptoms by the decrease of both total WOMAC index and VAS score.

journal_name

Int Orthop

authors

García-Coronado JM,Martínez-Olvera L,Elizondo-Omaña RE,Acosta-Olivo CA,Vilchez-Cavazos F,Simental-Mendía LE,Simental-Mendía M

doi

10.1007/s00264-018-4211-5

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

531-538

issue

3

eissn

0341-2695

issn

1432-5195

pii

10.1007/s00264-018-4211-5

journal_volume

43

pub_type

杂志文章,meta分析,评审
  • Duplex ultrasonography after total hip or knee arthroplasty.

    abstract::We prospectively studied all patients admitted for total hip (THR) or knee (TKR) arthroplasty from July 2000 to February 2001. No pharmacological anticoagulation was given. All patients received a standardized postoperative rehabilitation regimen. Forty-six patients with known risk factors for deep vein thrombosis (DV...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-003-0427-z

    authors: Ko PS,Chan WF,Siu TH,Cheng A,Lee OB,Lam JJ

    更新日期:2003-01-01 00:00:00

  • Comparison between uncemented and cemented fixation for the tibial component in distal femoral replacement: a clinical and radiological study.

    abstract:PURPOSES:We performed a retrospective, cohort study to compare uncemented tibial fixation with cemented tibial fixation in distal femoral replacement (DFR). METHODS:Sixty-two cases with uncemented tibial fixation and 58 cases with cemented tibial fixation were included. Inter-group comparisons were performed for basel...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-018-3847-5

    authors: Liang H,Guo W,Yang R,Tang X,Yan T

    更新日期:2018-09-01 00:00:00

  • A 4-year study of the mycological aspects of Kashin-Beck disease in Tibet.

    abstract::In order to clarify the association between mycotoxin-producing fungi in food and Kashin-Beck disease (KBD), we examined the occurrence and contamination levels of fungi in samples of barley grain, from KBD-affected families and from unaffected families in endemic areas. A control area without the occurrence of KBD se...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640000218

    authors: Chasseur C,Suetens C,Michel V,Mathieu F,Begaux F,Nolard N,Haubruge E

    更新日期:2001-01-01 00:00:00

  • Retrospective high volume comparative study suggests that patients on aspirin could have immediate surgery for hip fractures without significant blood loss.

    abstract:PURPOSE:This study aimed to investigate the effects of aspirin on peri-operative hidden blood loss during hip fracture surgery by adjusting for possible factors affecting blood loss using a propensity score matching method. METHODS:We retrospectively collected data from a cohort of isolated hip fracture patients (aged...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-021-04941-6

    authors: Ohmori T,Toda K,Kanazawa T,Tada K,Yagata Y,Ito Y

    更新日期:2021-01-30 00:00:00

  • Occult intra-operative periprosthetic fractures of the acetabulum may affect implant survival.

    abstract:PURPOSE:Occult intra-operative periprosthetic acetabular fracture is a seldom-reported complication of primary total hip arthroplasty (THA). It may potentially be associated with cup instability and implant loosening. The present study aimed to investigate clinical consequences of this complication. METHODS:Between 20...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-018-4084-7

    authors: Dammerer D,Putzer D,Glodny B,Petersen J,Arrich F,Krismer M,Biedermann R

    更新日期:2019-07-01 00:00:00

  • Fibula-pro-tibia in plating tibial non-unions.

    abstract:PURPOSE:Plating non-unions of the tibial diaphysis often presents the technical problem of poor purchase of screws due to osteoporosis. To improve the stabilization, insertion of one or more screws through the plate across the tibio-fibular space to the fibula (fibula-pro-tibia plating) has been practiced. The aim of t...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-011-1211-0

    authors: Said GZ,El-Sharkawi MM,Said HG,Refai OA

    更新日期:2011-11-01 00:00:00

  • Three-in-one protocol reduces mortality of patients with haemodynamically unstable pelvic fractures-a five year multi-centred review in Hong Kong.

    abstract:PURPOSE:The mortality rate in patients with haemodynamically unstable pelvic fractures is as high as 40-60%. Despite the new advances in trauma care which are in phase in trauma centres in Hong Kong, the management of haemodynamically unstable pelvic fracture is still heterogeneous. The aim of this study is to review t...

    journal_title:International orthopaedics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00264-018-3842-x

    authors: Cheng M,Lee KY,Chang AL,Ho HF,Chan LS,Lee KB,Kwok PH,Lee AW,Wong KK,Kam CW,Leung GK,Wong JS,Cheung NK,Yeung JH,Tang N,Choi SH,Lau TW,Wong HT,Leung M

    更新日期:2018-10-01 00:00:00

  • Anterior thigh pain after cementless total hip arthroplasty.

    abstract::We compared the incidence of anterior thigh pain retrospectively following primary uncemented total hip replacement in 70 patients (78 hips) with osteoarthritis. In one group (38 hips), an Endoplus porous-coated, canal-filling prosthesis was inserted through an anterolateral approach. In the other group (40 hips), a F...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-005-0642-x

    authors: Faraj AA,Yousuf M

    更新日期:2005-06-01 00:00:00

  • Variables influencing the pelvic radiological evaluation in children with developmental dysplasia of the hip managed by closed reduction: a multicentre investigation.

    abstract:PURPOSE:This study aims to evaluate (1) the probability to achieve normal pelvic radiographs in children with developmental dysplasia of the hip (DDH) treated by closed reduction and (2) the amount of time needed to achieve normal pelvic radiographs and to assess what factors influence both probability and time to achi...

    journal_title:International orthopaedics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00264-020-04479-z

    authors: Li Y,Liu H,Guo Y,Xu H,Xun F,Liu Y,Yuan Z,Li J,Pereira B,Canavese F,Chinese Multicenter Pediatric Orthopaedic Study Group (CMPOS).

    更新日期:2020-03-01 00:00:00

  • External fixation in tumour pathology.

    abstract::An appraisal of the clinical records of patients with malignant bone tumours enabled us to identify 61 whom we have treated by external fixation. There were 38 males and 23 females with ages ranging from 4 to 58 years, the mean being 14 years. The average period of follow-up was 6 years (1-12 years). For the purpose o...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640050223

    authors: Cañadell J,San-Julian M,Cara J,Forriol F

    更新日期:1998-01-01 00:00:00

  • Patient-specific cutting guides for open-wedge high tibial osteotomy: safety and accuracy analysis of a hundred patients continuous cohort.

    abstract:INTRODUCTION:Several recent studies have reported accurate and reliable use of patient-specific cutting guides (PSCG) for medial opening-wedge high tibial osteotomy (OW-HTO); however, a majority of these are small cases series or ex-vivo reports. The hypothesis of this study was that performing an OW-HTO with PSCG resu...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-019-04372-4

    authors: Chaouche S,Jacquet C,Fabre-Aubrespy M,Sharma A,Argenson JN,Parratte S,Ollivier M

    更新日期:2019-12-01 00:00:00

  • Relationship of body mass index to early complications in hip replacement surgery : study performed at Hinchingbrooke Hospital, Orthopaedic Directorate, Huntingdon, Cambridgeshire.

    abstract::The purpose of this study was to evaluate the relationship between body mass index and early complications following total hip replacements. Five hundred and fifty patients who underwent primary total hip replacement were recruited. All these patients were subjected to a pre-operative assessment and follow-up at 6 wee...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-006-0222-8

    authors: Patel AD,Albrizio M

    更新日期:2007-08-01 00:00:00

  • Inefficacy of autologous bone marrow concentrate in stage three osteonecrosis: a randomized controlled double-blind trial.

    abstract:PURPOSE:The fracture stage of non-traumatic osteonecrosis (ON stage 3) of the femoral head (ONFH) has an unfavourable prognosis frequently requiring total hip replacement (THR). The percentage could be lowered after core decompression. In earlier non-fracture ON stages, implantation of autologous bone marrow aspirate c...

    journal_title:International orthopaedics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00264-017-3650-8

    authors: Hauzeur JP,De Maertelaer V,Baudoux E,Malaise M,Beguin Y,Gangji V

    更新日期:2018-07-01 00:00:00

  • Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect.

    abstract::A full thickness defect was made in the central portion of the patellar tendon of 48 New Zealand white rabbits. Platelet-rich plasma (PRP) gel was then applied and filled the tendon defect. The same procedure was performed in the control group, without the application of PRP. Animals were sacrificed after one, two, th...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-009-0728-y

    authors: Lyras D,Kazakos K,Verettas D,Polychronidis A,Simopoulos C,Botaitis S,Agrogiannis G,Kokka A,Patsouris E

    更新日期:2010-02-01 00:00:00

  • Osteosarcoma associated with a metal implant.

    abstract::An osteosarcoma developed in a boy, 16 years of age, 9 years after staples had been inserted in the region of the lower femoral epiphysis. The possible association between the implant and the tumour is discussed. ...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640050090

    authors: Kumar K

    更新日期:1996-01-01 00:00:00

  • Translaminar screw fixation of the lumbar spine.

    abstract::Lower lumbar spinal fusion was carried out in 72 patients by a technique which involved screw fixation of the facet joints. Stability was achieved and mobilisation was allowed immediately. Radiographs after operation showed bony fusion in 94.5%. Pain was diminished and 76% of the patients would undergo the same treatm...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/BF00182698

    authors: Grob D,Rubeli M,Scheier HJ,Dvorak J

    更新日期:1992-01-01 00:00:00

  • Better results with patelloplasty compared to traditional total knee arthroplasty.

    abstract:PURPOSE:The aim of this study was to compare the results of primary total knee arthroplasty with or without patelloplasty. METHODS:We retrospectively reviewed 89 patients who had received total knee arthroplasty. In patelloplasty, the patellar cartilage was resected using a tangential saw cut, and in the traditional t...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-014-2366-2

    authors: Župan A,Snoj Ž,Antolič V,Pompe B

    更新日期:2014-08-01 00:00:00

  • Injury severity in ice skating: an epidemiologic analysis using a standardised injury classification system.

    abstract:PURPOSE:Although injuries sustained during ice skating have been reported to be more serious than other forms of skating, the potential injury risks are often underestimated by skating participants. The purpose of this study was to give a descriptive overview of injury patterns occurring during ice skating. Special emp...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-014-2488-6

    authors: Ostermann RC,Hofbauer M,Tiefenböck TM,Pumberger M,Tiefenböck M,Platzer P,Aldrian S

    更新日期:2015-01-01 00:00:00

  • Arthrodesis of the wrist by a new technique.

    abstract::Twenty-eight arthrodeses of the wrist were carried out for various indications using an ulnar graft. The results were evaluated and it was found that the obliquely resected lower end of the ulna gave a longer graft for better fusion between the distal end of radius and the base of the 3rd metacarpal. There was no inst...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/BF00180131

    authors: Mittal RL,Jain NC

    更新日期:1990-01-01 00:00:00

  • Reduction and internal fixation of displaced intra-articular calcaneal fractures with a locking nail: a prospective study of sixty nine cases.

    abstract:PURPOSE:The best treatment for intra-articular fractures of the calcaneus is still debated. The aims of this study were to determine whether intrafocal reduction of thalamic fractures is effective, to evaluate whether a locking nail is able to maintain reduction of the articular surface and to analyse the functional re...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-2816-5

    authors: Simon P,Goldzak M,Eschler A,Mittlmeier T

    更新日期:2015-10-01 00:00:00

  • Biomechanical reconstruction of the hip: comparison between modular short-stem hip arthroplasty and conventional total hip arthroplasty.

    abstract:PURPOSE:Short-stem hip arthroplasty preserves femoral bone stock which includes the femoral neck. This implies that the stem has to follow the anatomy of the femoral neck. Therefore, it has been questioned whether biomechanical reconstruction of the hip can be safely achieved with SHA. METHODS:Biomechanical reconstruc...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-011-1477-2

    authors: Schmidutz F,Beirer M,Weber P,Mazoochian F,Fottner A,Jansson V

    更新日期:2012-07-01 00:00:00

  • Epidemiology of humeral fractures in Malawi.

    abstract::We analysed and determined retrospectively the location, age, gender and side of the body of humeral fractures from 258 antero-posterior radiographs of all patients aged 3-81 years over a 5-year period. It was observed that 160 fractures occurred on the left side while 98 were on the right side with 156 occurring in m...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-004-0596-4

    authors: Igbigbi PS,Manda K

    更新日期:2004-12-01 00:00:00

  • The relevance of the anatomical basis of fracture for the subsequent treatment of the anterior humeral circumflex artery and the axillary nerve.

    abstract:PURPOSE:The purpose of this study was to determine the location of the anterior humeral circumflex artery and axillary nerve based on bony landmarks, and to provide anatomical information that enables a safe approach when treating a proximal humeral fractures. METHODS:Thirty cadavers were included. The distances of bo...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-011-1394-4

    authors: Chen YF,Zhu NF,Zhang CQ,Wang L,Wei HF,Lu Y

    更新日期:2012-04-01 00:00:00

  • The microbiology of the infected knee arthroplasty.

    abstract::We describe the results of a retrospective analysis of patients with microbiologically proven infection, who underwent revision TKA between 1994 and 2008. Of the 121 patients included in the study, 61 (50%) were male and 60 (50%) were female. The mean age was 71 (range 42-88) years. The most common organisms identifie...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-009-0797-y

    authors: Nickinson RS,Board TN,Gambhir AK,Porter ML,Kay PR

    更新日期:2010-04-01 00:00:00

  • Efficacy and complications of open and minimally invasive surgery in acute Achilles tendon rupture: a prospective randomised clinical study--preliminary report.

    abstract:PURPOSE:Surgical treatment of an acute Achilles tendon rupture can effectively reduce the risk of re-rupture, but it increases the probability of surgical complications. We postulated that a minimally invasive surgical treatment might reduce the number of complications related to open surgery and improve the functional...

    journal_title:International orthopaedics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00264-012-1737-9

    authors: Kołodziej L,Bohatyrewicz A,Kromuszczyńska J,Jezierski J,Biedroń M

    更新日期:2013-04-01 00:00:00

  • Effects of aggressive early rehabilitation on the outcome of anterior cruciate ligament reconstruction with multi-strand semitendinosus tendon.

    abstract::To evaluate the effects of aggressive early rehabilitation on the clinical outcome of anterior cruciate ligament reconstruction using semitendinosus (and gracilis) tendon, 103 of 110 consecutive patients who underwent ACL reconstruction using multistrand semitendinosus tendon (ST) or the central one-third of patellar ...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640050276

    authors: Muneta T,Sekiya I,Ogiuchi T,Yagishita K,Yamamoto H,Shinomiya K

    更新日期:1998-01-01 00:00:00

  • Long-term results of acetabular reconstruction using three bulk bone graft techniques in cemented total hip arthroplasty for developmental dysplasia.

    abstract:PURPOSE:The aims of this retrospective study were to firstly introduce three practical bulk bone graft techniques based on acetabular morphology for dysplasia and secondly evaluate the long-term durability of acetabular reconstruction using those techniques combined with cemented total hip arthroplasty (THA). METHODS:...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-3039-5

    authors: Oe K,Iida H,Kawamura H,Ueda N,Nakamura T,Okamoto N,Ueda Y

    更新日期:2016-09-01 00:00:00

  • Manipulation under anaesthesia for frozen shoulder in patients with and without non-insulin dependent diabetes mellitus.

    abstract::Manipulation under anaesthesia (MUA) has been used to speed up recovery. However, the outcome of frozen shoulder after MUA in patients with diabetes has not been well documented in the past. A higher prevalence of frozen shoulder has been reported in diabetes mellitus (DM) patients. In this study, we revealed the shor...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-010-0968-x

    authors: Wang JP,Huang TF,Ma HL,Hung SC,Chen TH,Liu CL

    更新日期:2010-12-01 00:00:00

  • Causes and preventive measures of symptomatic spinal epidural haematoma after spinal surgery.

    abstract:STUDY DESIGN:This was a retrospective study to evaluate clinical characteristics of patients who developed symptomatic spinal epidural haematoma (SSEH) after spinal surgery. OBJECTIVE:The objective was to determine clinical parameters associated with the development of SSEH after spinal surgery, and to discuss clinica...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-017-3506-2

    authors: Zeng XJ,Wang W,Zhao Z,Li M

    更新日期:2017-07-01 00:00:00

  • Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study.

    abstract:PURPOSE:The purpose of this study was to evaluate the efficiency of biologic augmentation of rotator cuff repair with iliac crest bone marrow-derived mesenchymal stem cells (MSCs). The prevalence of healing and prevention of re-tears were correlated with the number of MSCs received at the tendon-to-bone interface. MET...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-014-2391-1

    authors: Hernigou P,Flouzat Lachaniette CH,Delambre J,Zilber S,Duffiet P,Chevallier N,Rouard H

    更新日期:2014-09-01 00:00:00