Abstract：
OBJECTIVES:Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in telomere length and frailty exist. DESIGN:Longitudinal cohort study. SETTING AND PARTICIPANTS:A subpopulation of the Helsinki Birth Cohort Study consisting of 1078 older adults aged 67 to 79 years born in Helsinki, Finland, between 1934 and 1944. MEASURES:Relative leukocyte telomere length (LTL) was measured using quantitative real-time polymerase chain reaction at the average ages of 61 and 71 years, and at the latter the participants were assessed for frailty according to Fried criteria. RESULTS:The mean ± SD relative LTLs were 1.40 ± 0.29 (average age 61 years) and 0.86 ± 0.30 (average age 71 years) for the cohort. A trend of shorter mean relative LTL across frailty groups was observed at 61 years (P = .016) and at 71 years (P = .057). Relative LTL at age 61 years was significantly associated with frailty: per 1-unit increase in relative LTL, the corresponding relative risk ratio (RRR) of frailty was 0.28 (95% confidence interval [CI] 0.08-0.97), adjusting for several confounders. Also, LTL at age 71 years was associated with frailty (RRR 0.18, 95% CI 0.04-0.81) after adjustment for sex, age, and adult socioeconomic status, but further adjustment attenuated the association. No associations between telomere shortening and frailty were observed during the 10-year follow-up. CONCLUSIONS:Shorter relative LTL was associated with frailty in cross-sectional and longitudinal analyses, but telomere shortening was not, suggesting that short LTL may be a biomarker of frailty.
journal_name
J Am Med Dir Assocjournal_title
Journal of the American Medical Directors Associationauthors
Haapanen MJ,Perälä MM,Salonen MK,Guzzardi MA,Iozzo P,Kajantie E,Rantanen T,Simonen M,Pohjolainen P,Eriksson JG,von Bonsdorff MBdoi
10.1016/j.jamda.2018.05.011subject
Has Abstractpub_date
2018-08-01 00:00:00pages
658-662issue
8eissn
1525-8610issn
1538-9375pii
S1525-8610(18)30265-2journal_volume
19pub_type
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章,评审
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
doi：10.1016/j.jamda.2012.05.013
更新日期：2012-09-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章,评审
doi：10.1016/j.jamda.2007.11.010
更新日期：2008-02-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
doi：10.1016/j.jamda.2019.08.022
更新日期：2020-05-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
doi：10.1016/j.jamda.2014.05.008
更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章
doi：
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
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更新日期：2021-01-18 00:00:00
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journal_title：Journal of the American Medical Directors Association
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更新日期：2019-11-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
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更新日期：2017-07-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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doi：
更新日期：2001-03-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2019-04-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章,评审
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更新日期：2006-06-01 00:00:00
