Abstract:
BACKGROUND:Oxidative stress (OS) plays a substantial role in inflammatory and neurodegenerative diseases, causing cellular damage and mitochondrial dysfunction. OS also contributes to aging and severe neural disorders such as Alzheimer's and Parkinson's diseases. Previous registries have documented a reduction in OS levels with Robuvit® (Horphag Research, Ltd.), an extract from wood of the French oak (Quercus robur) that provides a decrease of OS as well as relief from chronic fatigue syndrome. The aim of the present registry was to investigate the influence of Robuvit® on a group of subjects presenting with mood disorders, oxidative stress, fatigue, and insomnia. METHODS:Forty patients were recruited from a selection of patients with high OS levels as assessed with the d-ROMs test. Twenty-two subjects formed the control group following the standard management plan. The remaining 18 subjects formed the Robuvit® supplementation group. They received three capsules of Robuvit® 100 mg per day, for 8 weeks. RESULTS:Tolerability to the supplementation with Robuvit® was overall good, and no safety concerns were raised. Mood tests showed a significant general improvement in 13 out of 16 items of the BMIS (P<0.05) in the active treatment group. Oxidative stress levels decreased significantly with Robuvit® supplementation after 4 and 8 weeks. Fatigue and insomnia score were also significantly better in supplemented subjects (P<0.05). No changes were observed in controls. CONCLUSIONS:The observed decrease in OS levels in our patients is probably the result of the antioxidative activity of Robuvit®, and, more precisely, of its active metabolites, the urolithins and ellagic acid.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Belcaro G,Saggino A,Cornelli U,Luzzi R,Dugall M,Hosoi M,Feragalli B,Cesarone MRdoi
10.23736/S0390-5616.18.04384-9subject
Has Abstractpub_date
2018-08-01 00:00:00pages
423-427issue
4eissn
0390-5616issn
1827-1855pii
S0390-5616.18.04384-9journal_volume
62pub_type
临床试验,杂志文章abstract::Chronic subdural hematoma pathophysiology has been extensively studied and discussed. In the last decades, optic and electron microscope observations have successfully described its histopathology and the ultrastructure of internal membranes. Moreover, recent biochemical studies have identified a number of important p...
journal_title:Journal of neurosurgical sciences
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abstract:INTRODUCTION:There is uncertainty as to the best management of arteriovenous malformations of the brain (bAVM). However, the Spetzler-Martin grade (SMG) has been validated as an effective determinant of surgical risks. We performed a systematic review for the best evidence regarding the management of bAVM for series th...
journal_title:Journal of neurosurgical sciences
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abstract::The results of a retrospective study of 24 adult patients with occult dysraphism are described. There were 15 males and 9 females, with an average age of 31.1 years. Specific circumstances precipitated symptomatic onset in 67% of patients. Pain, often referred to the anorectal region, was the most common presenting sy...
journal_title:Journal of neurosurgical sciences
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abstract::The brainstem is an uncommon site for a brain abscess. It accounts for less than 4% of all posterior cranial fossa abscesses, and less than 1% of all intracranial abscesses. The pons is the most common site for these abscesses. The aim of the present report was to describe the case of a Brazilian Amazon man with a bra...
journal_title:Journal of neurosurgical sciences
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abstract::The Authors report 4 cases of spinal lipomas: 2 intradural, 2 completely intrarachidian extradural. The intradural lipomas observed were 2 cases in the lumbo-sacral area, both operated on by the partial removal of the lesion with very good clinical results; histologically they were found to be 2 fibrolipomas. The 2 ca...
journal_title:Journal of neurosurgical sciences
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abstract:INTRODUCTION:To determine the association between magnetic resonance imaging (MRI)-detected vulnerable Carotid Plaques and clinical presentation related to ipsilateral carotid artery territory. EVIDENCE ACQUISITION:We searched three databases including Ovid MEDLINE, Ovid EMBASE, and Scopus from 2000 to 2018 for studie...
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abstract:BACKGROUND:Economical studies on surgery of intracranial aneurysms have considered only the significant benefit of surgical approach on unruptured aneurysms and no studies have been performed comparing cost/benefit analysis of early vs delayed surgery. The present study was retrospectively performed in order to verify ...
journal_title:Journal of neurosurgical sciences
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abstract::Between 1985 and 1993, we treated seven cases of optic nerve sheath meningiomas. The median age at onset of their symptoms was 42.14 years. All of the patients were aged between 27 and 60 females with a slowly progressive lesion. Computed tomography and/or magnetic resonance imaging were used as diagnostic procedure i...
journal_title:Journal of neurosurgical sciences
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abstract:BACKGROUND:Spinal surgery has to address the challenge of a dramatic increase of the growing number of older persons. The purpose of the present study was to project the numbers of surgically treated degenerative spine disease (DSD) in Austria from 2017 until 2080 to provide potential future scenarios that the Austrian...
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journal_title:Journal of neurosurgical sciences
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更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Meningiomas have been found to have receptors for several hormones, such as oestrogen, progesterone, somatostatin, dopamine and recently also for prolactin. METHODS:To investigate any possible role of prolactin in the growth of those tumours we detected the presence of prolactin-receptors (PRL-R) in 22 meni...
journal_title:Journal of neurosurgical sciences
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journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
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journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:10.23736/S0390-5616.17.04133-9
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abstract::Free fat in the ventricular space is a rare but well recognized complication of ruptured tumour of dermal origin. However, only 1 patient of spontaneous rupture of spinal dermoid tumour with disseminated fat in the central canal and ventricles has been described in the literature. The authors report an extremely rare ...
journal_title:Journal of neurosurgical sciences
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更新日期:2004-06-01 00:00:00
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journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
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journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1980-04-01 00:00:00
abstract::A case of a 61-year-old female patient who presents with the clinical triad of normal pressure hydrocephalus (NPH), abnormal gait, urinary incontinence and dementia. On CT scanning, she is found to have a large arachnoid cyst which mimicked the syndrome of NPH. This is also the 60th published case of arachnoid cyst pr...
journal_title:Journal of neurosurgical sciences
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doi:
更新日期:2006-09-01 00:00:00
abstract::Primary cerebellar glioblastoma multiforme (GBM) is a rare tumor in adults that accounts for just 1% of all cases of GBM. Cerebellar GBMs are not yet completely understood also as far as the prognosis. We report a case of cerebellar GBM in a 27-year-old woman. Magnetic resonance imaging (MRI) showed a 3x3.6 cm-sized, ...
journal_title:Journal of neurosurgical sciences
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更新日期:2012-12-01 00:00:00
abstract:AIM:The novel YL-1 hollow needle aspiration drainage system is an effective minimally invasive treatment in chronic subdural hematoma (CSDH). In order to find the risk prognosis factors of chronic subdural hematoma (CSDH) performed by the novel YL-1 hollow needle aspiration drainage system, a logistic analysis of posto...
journal_title:Journal of neurosurgical sciences
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journal_title:Journal of neurosurgical sciences
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journal_title:Journal of neurosurgical sciences
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journal_title:Journal of neurosurgical sciences
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journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2011-03-01 00:00:00
abstract::Starting from January 2008, we systematically irrigated the surgical wounds of patients undergoing spine surgery with a solution of povidone-iodine and hydrogen peroxide. We prospectively recorded the clinical data of patients who underwent spine surgery during 2008 and we compared the results with retrospectively rev...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,收录出版
doi:
更新日期:2011-06-01 00:00:00
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journal_title:Journal of neurosurgical sciences
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journal_title:Journal of neurosurgical sciences
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journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
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journal_title:Journal of neurosurgical sciences
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更新日期:2000-06-01 00:00:00
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journal_title:Journal of neurosurgical sciences
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